Powder: -20°C for 3 years | In solvent: -80°C for 1 year
p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets[1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 2,480 | 5日内发货 | ||
5 mg | ¥ 2,890 | 5日内发货 | ||
25 mg | ¥ 10,800 | 6-8周 | ||
50 mg | ¥ 14,100 | 6-8周 | ||
100 mg | ¥ 19,500 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,970 | 5日内发货 |
产品描述 | P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6. It also demonstrates inhibition of the hERG ion channel (IC50=27 μM) and maintains promising selectivity, with <30% inhibition across a panel of 51 protein kinases at a 10 μM concentration and a broad specificity against 141 other biological targets[1]. |
分子量 | 475.58 |
分子式 | C27H33N5O3 |
CAS No. | 1095003-80-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (525.67 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1027 mL | 10.5135 mL | 21.027 mL | 52.5674 mL |
5 mM | 0.4205 mL | 2.1027 mL | 4.2054 mL | 10.5135 mL | |
10 mM | 0.2103 mL | 1.0513 mL | 2.1027 mL | 5.2567 mL | |
20 mM | 0.1051 mL | 0.5257 mL | 1.0513 mL | 2.6284 mL | |
50 mM | 0.0421 mL | 0.2103 mL | 0.4205 mL | 1.0513 mL | |
100 mM | 0.021 mL | 0.1051 mL | 0.2103 mL | 0.5257 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
p38α inhibitor 2 1095003-80-7 p38a inhibitor 2 p38alpha inhibitor 2 p-38α inhibitor 2 Inhibitor inhibitor inhibit