2
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6730 |
WAY-600
6-(1H-吲哚-5-基)-4-(4-吗啉基)-1-[1-(3-吡啶基甲基)-4-哌啶基]-1H-吡唑并[3,4-D]嘧啶,WAY600 |
VEGFR; PI3K; Src; mTOR | Angiogenesis; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
WAY-600 是一种有效的,选择性的,ATP 竞争型的mTOR 抑制剂,抑制重组 mTOR 酶,其 IC50=9 nM。它能够阻断 mTOR 复合物 1/2 (mTORC1/2) 组装和激活。 | |||
T79353 |
P-gp/BCRP-IN-2
|
Others | Others |
P-gp/BCRP-IN-2(化合物15)为恶二唑衍生物,作为ABC转运蛋白P-glycoprotein(IC50:1.6 nM)及BCRP(IC50:600 nM)的双重抑制剂。该化合物增强了Doxorubicin针对耐药型人腺癌结肠癌细胞系HT29/DX及MDCK-MDR1细胞的抗增殖效果。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01993 |
IL-13 Protein, Human, Recombinant
IL-13,P600,interleukin 13,ALRH,白介素,白细胞介素 |
Human | CHO Cells |
IL-13 Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.5 kDa and the accession number is AAK53823.1. | |||
TMPY-00840 |
IL-13 Protein, Human, Recombinant (hFc)
IL-13,白介素,白细胞介素,ALRH,interleukin 13,P600 |
Human | HEK293 Cells |
IL-13 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39 kDa and the accession number is AAK53823.1. | |||
TMPJ-00889 |
IL-13 Protein, Mouse, Recombinant (aa 22-131, His)
T-Cell Activation Protein P600,IL... |
Mouse | HEK293 Cells |
IL-13 Protein, Mouse, Recombinant (aa 22-131, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 14-30 KDa and the accession number is P20109. | |||
TMPJ-00890 |
IL-13 Protein, Mouse, Recombinant (aa 26-131, His)
Interleukin-13,T-Cell Activation Protein P... |
Mouse | HEK293 Cells |
IL-13 Protein, Mouse, Recombinant (aa 26-131, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 15-30 KDa and the accession number is P20109. | |||
TMPK-00617 |
IL-13 Protein, Human, Recombinant (His & Avi)
NC30,ALRH,IL13,MGC116786,MGC116789,P600,MG... |
Human | HEK293 Cells |
Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macro... |