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Search Results for " nkg2d "

3

抑制剂 & 化合物

27

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T81669	NKG2D-IN-2
	NKG2D-IN-2（化合物47）为NKG2D抑制剂，其IC50在NKG2D/MICA及ULBP6 TR-FRET测定中分别为0.1 µM与0.2 µM。
T81670	NKG2D-IN-1
	NKG2D-IN-1（compound 21）是一种NKG2D抑制剂，其在NKG2D/MICA和ULBP6 TR-FRET测定中的IC50值分别为0.3 µM和0.7 µM。
T77404	Tesnatilimab IPH-23XX,JNJ-64304500,JNJ 4500	Others	Others
	Tesnatilimab 是一种有效的人源化 IgG4 单克隆抗体，可与免疫激活受体 NKG2D 结合。Tesnatilimab 具有潜在的免疫调节和抗炎活性，可用于研究活动性溃疡性结肠炎。

化合物

Cat.No: T81669

Cat.No: T81670

Cat.No: T77404

Synonym: IPH-23XX,JNJ-64304500,JNJ 4500

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05414	NKG2D/CD314 Protein, Mouse, Recombinant (hFc) D6H12S2489E,NKG2-D,killer cell lectin-like receptor...	Mouse	Baculovirus Insect Cells
	NKG2D/CD314 Protein, Mouse, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is O54709-2.
TMPY-00467	NKG2D/CD314 Protein, Human, Recombinant (hFc) D12S2489E,killer cell lectin-like receptor subfamily K, memb...	Human	CHO Cells
	NKG2D/CD314 Protein, Human, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 46.5 kDa and the accession number is A0A024RAP8.
TMPY-03376	NKG2D/CD314 Protein, Rhesus, Recombinant (aa 78-216, His) NKG2-D,NKG2D,KLRK1,killer cell le...	Rhesus	Baculovirus Insect Cells
	NKG2D/CD314 Protein, Rhesus, Recombinant (aa 78-216, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 18.3 kDa and the accession number is P61252.
TMPY-03256	NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His) KLR,killer cell lectin-like receptor subfamily K, member 1,D...	Human	Baculovirus Insect Cells
	NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 18.4 kDa and the accession number is P26718-1.
TMPK-00108	NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag) NKG2D,NKG2-D,CD314,KLR,D12S2489E	Human	HEK293 Cells
	NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8 alpha beta T cells, gamma δ T cells, NK cells and NKT cells. NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag) is expressed in HEK293 mammalian cells with N-hFc-Flag tag. The predicted molecular weight is 43.4 kDa and the accession numbe...
TMPK-00106	NKG2D/CD314 Protein, Human, Recombinant (His & Avi), Biotinylated NKG2D,NKG2-D,KLR,CD314,D12S2489E	Human	HEK293 Cells
	NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8 alpha beta T cells, gamma δ T cells, NK cells and NKT cells. NKG2D/CD314 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 19.0 kDa and the acc...
TMPK-00105	NKG2D/CD314 Protein, Human, Recombinant (His & Avi) NKG2-D,KLR,CD314,NKG2D,D12S2489E	Human	HEK293 Cells
	NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8 alpha beta T cells, gamma δ T cells, NK cells and NKT cells. NKG2D/CD314 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 19.0 kDa and the accession number ...
TMPK-00107	NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag), FITC-Labeled NKG2D,KLR,CD314,D12S2489E,NKG2-D	Human	HEK293 Cells
	NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8 alpha beta T cells, gamma δ T cells, NK cells and NKT cells. NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag), FITC-Labeled is expressed in HEK293 mammalian cells with N-hFc-Flag tag. The predicted molecular weight is 43.4 kDa and the a...
TMPY-06827	NKG2D/CD314 Protein, Human, Recombinant (mFc) killer cell lectin-like receptor subfamily K, member 1,N...	Human	Baculovirus Insect Cells
	NKG2D/CD314 Protein, Human, Recombinant (mFc) is expressed in Baculovirus insect cells with mFc tag. The predicted molecular weight is 41.83 kDa and the accession number is P26718-1.
TMPJ-00097	NKG2D/CD314 Protein, Cynomolgus, Recombinant (hFc) member 1,NK cell receptor D,NKG2-D-activating NK re...	Cynomolgus	HEK293 Cells
	NKG2D/CD314 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-Fc tag. The predicted molecular weight is 50-70 KDa and the accession number is P61252.
TMPJ-00122	NKG2D/CD314 Protein, Mouse, Recombinant (His) KLR,NKG2-D type II integral membrane protein,CD314,...	Mouse	HEK293 Cells
	NKG2D/CD314 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 20-30 KDa and the accession number is O54709.
TMPK-00136	ULBP-2 Protein, Human, Recombinant (His & Avi) ALCAN-α,RAET1L,NKG2D ligand 2,ALCAN-alpha,...	Human	HEK293 Cells
	ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity.
TMPK-00137	ULBP-2 Protein, Human, Recombinant (His & Avi), Biotinylated ALCAN-α,NKG2DL2,ULBP2,ALCAN-alpha,ULBP-2/5...	Human	HEK293 Cells
	ULBP2 expression was however linked to expression of mature CD57() NK cells. In particular, expression of ULBP2 was strongest on those NK cells that had evidence of recent activation and proliferation. We suggest that ULBP2 could be used to identify recently activated "mature" NK cells.
TMPJ-00131	NKG2DL Protein, Human, Recombinant (hFc) ALCAN-β,NKG2DL1,UL16-binding protein 1,	Human	HEK293 Cells
	NKG2D ligand 1, also called ULBP1, is a member of UL16-binding protein (ULBP) family which has also been termed the retinoic acid early transcript 1 (RAET1) family. Unlike the classical MHC class I molecules and the MIC molecules possess α1, α2 and α3 domains, ULBP/RAET1 family members lack α3 domain. ULBP1 is recognized by the activating receptor NKG2D on the surface of cytotoxic natural killer (NK) and T cells, and then promotes the lysis of cells expressing ULBP1 which is important for the im...
TMPK-00135	ULBP-1 Protein, Human, Recombinant (His & Avi), Biotinylated ALCAN-β,NKG2D ligand 1,ULBP-1,NKG...	Human	HEK293 Cells
	Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natural killer (NK) cells. ULBP-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.2 kDa and the accession number is Q9BZM6.
TMPK-00134	ULBP-1 Protein, Human, Recombinant (His & Avi) ALCAN-beta,ALCAN-β,ULBP-1,MULT-1,NKG2D lig...	Human	HEK293 Cells
	Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natural killer (NK) cells. ULBP-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.2 kDa and the accession number is Q9BZM6.
TMPK-00246	MICB Protein, Human, Recombinant (His & Avi), Biotinylated MIC-B,MICB,PERB11.2	Human	HEK293 Cells
	MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. MICB Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His...
TMPK-00247	MICB Protein, Human, Recombinant (hFc) MIC-B,PERB11.2,MICB	Human	HEK293 Cells
	MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. MICB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted ...
TMPK-00245	MICB Protein, Human, Recombinant (His & Avi) PERB11.2,MICB,MIC-B	Human	HEK293 Cells
	MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. MICB Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The ...
TMPK-00219	MICA Protein, Human, Recombinant (His & Avi), Biotinylated MICA,MGC21250,DAMA-345G11.2,MGC111087,FLJ60820,FLJ36918,PERB...	Human	HEK293 Cells
	TMICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig‑like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin.
TMPK-00221	MICA alpha 3 Protein, Human, Recombinant (mFc) MICA alpha 3,MICA α 3,MICA,MIC-A	Human	HEK293 Cells
	MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig‑like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin.. MICA alpha 3 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predi...
TMPK-00218	MICA Protein, Human, Recombinant (His & Avi) FLJ36918,FLJ60820,MICA,MGC111087,PERB11.1,DAMA-345G11.2,MGC2...	Human	HEK293 Cells
	MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig‑like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin.. MICA Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The pre...
TMPK-00220	MICA Protein, Human, Recombinant (hFc) MGC111087,FLJ36918,MICA,PERB11.1,DAMA-345G11.2,MGC21250,FLJ6...	Human	HEK293 Cells
	MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig‑like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin.. MICA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted mol...
TMPY-00190	ULBP-6 Protein, Human, Recombinant (hFc) retinoic acid early transcript 1L,RAET1L,ULBP6	Human	HEK293 Cells
	ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in several human papillomavirus-positive cervical carcinoma cell lines and was inducible on infection with human CMV. Expression of ULBP6 on target cells induced a significant increase in NK-cell killing. ULBP-6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cel...
TMPY-00575	ULBP-6 Protein, Human, Recombinant (His) RAET1L,retinoic acid early transcript 1L,ULBP6	Human	HEK293 Cells
	ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in several human papillomavirus-positive cervical carcinoma cell lines and was inducible on infection with human CMV. Expression of ULBP6 on target cells induced a significant increase in NK-cell killing. ULBP-6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cel...
TMPJ-01212	ULBP-1 Protein, Mouse, Recombinant (His) RAET1I,ULBP1,NKG2DL1	Mouse	HEK293 Cells
	Mouse ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or inte...
TMPY-03977	DAP10 Protein, Human, Recombinant (mFc) PIK3AP,DAP10,hematopoietic cell signal transducer,KAP10	Human	HEK293 Cells
	HCST (Hematopoietic Cell Signal Transducer, also known as DAP1) is a Protein Coding gene. HCST belongs to the DAP10 family. It is a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. HCST may be part of the immune recognition receptor complex. This receptor plays a major role in triggering cytotoxicity against target cells expressing cell sur...

重组蛋白

NKG2D/CD314 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-05414

Species: Mouse

Expression System: Baculovirus Insect Cells

NKG2D/CD314 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00467

Species: Human

Expression System: CHO Cells

NKG2D/CD314 Protein, Rhesus, Recombinant (aa 78-216, His)

Cat.No: TMPY-03376

Species: Rhesus

Expression System: Baculovirus Insect Cells

NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His)

Cat.No: TMPY-03256

Species: Human

Expression System: Baculovirus Insect Cells

NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag)

Cat.No: TMPK-00108

Species: Human

Expression System: HEK293 Cells

NKG2D/CD314 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00106

Species: Human

Expression System: HEK293 Cells

NKG2D/CD314 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00105

Species: Human

Expression System: HEK293 Cells

NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag), FITC-Labeled

Cat.No: TMPK-00107

Species: Human

Expression System: HEK293 Cells

NKG2D/CD314 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-06827

Species: Human

Expression System: Baculovirus Insect Cells

NKG2D/CD314 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPJ-00097

Species: Cynomolgus

Expression System: HEK293 Cells

NKG2D/CD314 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00122

Species: Mouse

Expression System: HEK293 Cells

ULBP-2 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00136

Species: Human

Expression System: HEK293 Cells

ULBP-2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00137

Species: Human

Expression System: HEK293 Cells

NKG2DL Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00131

Species: Human

Expression System: HEK293 Cells

ULBP-1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00135

Species: Human

Expression System: HEK293 Cells

ULBP-1 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00134

Species: Human

Expression System: HEK293 Cells

MICB Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00246

Species: Human

Expression System: HEK293 Cells

MICB Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00247

Species: Human

Expression System: HEK293 Cells

MICB Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00245

Species: Human

Expression System: HEK293 Cells

MICA Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00219

Species: Human

Expression System: HEK293 Cells

MICA alpha 3 Protein, Human, Recombinant (mFc)

Cat.No: TMPK-00221

Species: Human

Expression System: HEK293 Cells

MICA Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00218

Species: Human

Expression System: HEK293 Cells

MICA Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00220

Species: Human

Expression System: HEK293 Cells

ULBP-6 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00190

Species: Human

Expression System: HEK293 Cells

ULBP-6 Protein, Human, Recombinant (His)

Cat.No: TMPY-00575

Species: Human

Expression System: HEK293 Cells

ULBP-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01212

Species: Mouse

Expression System: HEK293 Cells

DAP10 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03977

Species: Human

Expression System: HEK293 Cells

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