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Search Results for " nct "

Targets Recommended: Gap Junction Protein Dehydrogenase FLT TAM Receptor

15

抑制剂 & 化合物

2

天然产物

1

化合物库

3

重组蛋白

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Cat. No.	Product Name
L7810	高溶解性多官能团片段化合物库		1159 compounds
	高溶解性多官能团片段库包含1159 种片段分子

化合物库

高溶解性多官能团片段化合物库

Cat.No: L7810

Compounds: 1159

Cat. No.	Product Name	Target	Signaling Pathways
T4213	NCT-503 NCT 503	Dehydrogenase; FLT; TAM Receptor	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	NCT-503 是一种磷酸甘油酸脱氢酶 (PHGDH) 抑制剂，其IC50=2.5 µM。
T38605	NCT-504	Others	Others
	NCT-504，作为一种选择性的PIP4Kγ的变构抑制剂，展现出15.8 μM的IC50值。该化合物对于亨廷顿病的研究具有潜力。
T16277	NCT-502 N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide	Dehydrogenase	Metabolism
	NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) 是磷酸甘油酸脱氢酶 (PHGDH) 抑制剂(IC50:3.7 μM)，对 PHGDH 依赖性癌细胞具有细胞毒性，能够减少葡萄糖衍生的丝氨酸的产生，。
T9996	NCT-58 NCT58	HSP	Cytoskeletal Signaling; Metabolism
	NCT-58是一种有效的C 端HSP90抑制剂。NCT-58不会引起热休克反应（HSR）。NCT-58通过同时下调HER 家族成员以及抑制Akt 磷酸化来激发抗肿瘤活性。NCT-58杀死对曲妥珠单抗耐药的乳腺癌干细胞样细胞。NCT-58诱导HER2阳性乳腺癌细胞凋亡。
T12196	NCT-505	Dehydrogenase	Metabolism
	NCT-505是乙醛脱氢酶的选择性抑制剂，IC50为 7 nM。对 hALDH1A2，hALDH1A3，hALDH2，hALDH3A1的抑制作用较弱，IC50分别为 >57，22.8，20.1，>57 μM。
T6903	NCT-501 NCT501	Dehydrogenase	Metabolism
	NCT-501 是一种茶碱类化合物，有效抑制醛脱氢酶 1A1(ALDH1A1), 抑制 hALDH1A1 IC50为 40 nM, 选择性超过其它 ALDH 同工酶和其它脱氢酶 (作用于 hALDH1B1, hALDH3A1, 和 hALDH2 时,IC50值 >57 UM)。
T25858	NCT-10b NCT 10b
	NCT-10b is a selective inhibitor of HDAC6.
T39485	NCT-501 hydrochloride
	NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), which is based on theophylline. It effectively inhibits hALDH1A1 with an IC50 value of 40 nM, exhibiting superior selectivity towards hALDH1A1 compared to other ALDH isozymes and dehydrogenases such as hALDH1B1, hALDH3A1, and hALDH2 (with IC50 values exceeding 57 μM).
T41159	NCT 501 hydrochloride
	NCT 501 hydrochloride is a potent and selective ALDH1A1 inhibitor (IC50 = 40 nM). Exhibits >1000-fold selectivity for ALDH1A1 over ALDH3A1, ALDH1B1, ALDH2, HPGD and HSD17β4. Also selective over a panel of 168 GPCRs. Blood-brain barrier permeable.
T12197	NCT-506	Others	Others
	NCT-506 is an orally bioavailable inhibitors of aldehyde dehydrogenase 1A1 (ALDH1A1) (IC50 of 7 nM).
T75344	NCT-TFP
	NCT-TFP 是 PARP 探针，用于鉴定聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂。
T60030	NCT02
	NCT02 是一种细胞周期蛋白 K 降解剂，可诱导细胞周期蛋白 K (CCNK) 的泛素化和 CCNK 及其复合物 CDK12 的蛋白酶体降解。NCT02具有研究转移性结直肠癌 (CRC) 的潜力。
T23150	PHGDH-inactive	Others	Others
	PHGDH-inactive 对 PHGDH 无活性，IC50大于57 μM，可用作 NCT-502 和 NCT-503 的阴性对照。
T34193	Punctaporonin D M 167906,M167906
	Punctaporonin D is an isomeric allylic alcohol from the fungus Poronia punctata.
T80371	Distinctin
	Distinctin是一种源自青蛙皮肤的抗菌肽，具有针对E. faecalis, P. aeruginosa, S. aureus和E. coli的抗菌活性，其最小抑菌浓度(MIC)分别为14.5 μM，28.0 μM，28.0 μM和14.5 μM。

化合物

Cat.No: T4213

Synonym: NCT 503

Target: Dehydrogenase, FLT, TAM Receptor

Cat.No: T38605

Target: Others

Cat.No: T16277

Synonym: N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide

Target: Dehydrogenase

Cat.No: T9996

Synonym: NCT58

Target: HSP

Cat.No: T12196

Target: Dehydrogenase

Cat.No: T6903

Synonym: NCT501

Target: Dehydrogenase

Cat.No: T25858

Synonym: NCT 10b

NCT-501 hydrochloride

Cat.No: T39485

NCT 501 hydrochloride

Cat.No: T41159

Cat.No: T12197

Target: Others

Cat.No: T75344

Cat.No: T60030

Cat.No: T23150

Target: Others

Punctaporonin D

Cat.No: T34193

Synonym: M 167906,M167906

Cat.No: T80371

Cat. No.	Product Name	Target	Signaling Pathways
TN3290	8-O-Demethyl-7-O-methyl-3,9-dihydropunctatin	Others	Others
	8-O-Demethyl-7-O-methyl-3,9-dihydropunctatin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3290，CAS号为 93078-83-2。
T26167	Rubropunctatin Rubropunctamine
	Rubropunctatin is a monascus pigment with very potent cancer cell proliferation inhibitory effects.

天然产物

8-O-Demethyl-7-O-methyl-3,9-dihydropunctatin

Cat.No: TN3290

Target: Others

Cat.No: T26167

Synonym: Rubropunctamine

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02910	Nicastrin Protein, Mouse, Recombinant (His) AA727311,NCSTN,Aph2,9430068N19Rik,Kiaa0253,Nct,D1Da...	Mouse	HEK293 Cells
	Nicastrin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73 kDa and the accession number is P57716.
TMPY-03074	Nicastrin Protein, Mouse, Recombinant (hFc) Aph2,AA727311,Nct,NCSTN,nicastrin,mKIAA0253,D1Dau13...	Mouse	HEK293 Cells
	Nicastrin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 98.5 kDa and the accession number is P57716.
TMPH-03528	Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc) chp,Chemotaxis inhibitory protein,CHIPS	Staphylococcus aureus	E. coli
	Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS...

重组蛋白

Nicastrin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02910

Species: Mouse

Expression System: HEK293 Cells

Nicastrin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03074

Species: Mouse

Expression System: HEK293 Cells

Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc)

Cat.No: TMPH-03528

Species: Staphylococcus aureus

Expression System: E. coli

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