Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22990 |
ML-090
Fluoflavine |
NADPH-oxidase; Others | Immunology/Inflammation; Others |
ML-090 是 NOX1 特异性抑制剂 (IC50 = 90 nM),对 NOX1 的特异性高于 NOX2、NOX3、NOX4(所有 IC50 > 10 μM)100倍。 | |||
T8408 |
GKT136901
AK120765 |
NADPH-oxidase; NADPH | Immunology/Inflammation; Metabolism |
GKT136901 (AK120765) 是选择性的和具有口服活性的 NADPH 氧化酶 NOX-1/4抑制剂,Ki 分别为 160 和 165 nM。它具有抗炎症活性。它也是一种选择性和直接的过氧亚硝酸清除剂。它可用于糖尿病肾病,中风和神经退行性疾病的研究。 | |||
T10353 |
APX-115 free base
Ewha-18278 free base |
NADPH-oxidase; NADPH | Immunology/Inflammation; Metabolism |
APX-115 free base (Ewha-18278 free base) 是口服具有活性的、非选择性的 Nox 抑制剂,对 Nox1,Nox2和 Nox4的 Ki 分别为 1.08 μM,0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。 | |||
T6099 |
Setanaxib
GKT137831 |
NADPH-oxidase; Ferroptosis; NADPH | Apoptosis; Immunology/Inflammation; Metabolism |
Setanaxib (GKT137831) 是一种有效的特异性双重 NADPH 氧化酶 (NOX1/4) 抑制剂,Ki 分别为140和110nM。 | |||
TP1886L1 |
NoxA1ds acetate(1435893-78-9 free base)
|
NADPH-oxidase | Immunology/Inflammation |
NoxA1ds acetate(1435893-78-9 free base) 是一种有效的选择性 NADPH 氧化酶 1 (NOX1) 抑制剂 (IC50 : 20 nM)。对 NOX1 的选择性优于对 NOX2、NOX4、NOX5 和黄嘌呤氧化酶的选择性。它抑制 HT-29 人结肠癌细胞中 NOX1 衍生的 O2 产生。在体外缺氧条件下减弱 VEGF 诱导的人肺动脉内皮细胞迁移。 | |||
T10354 |
APX-115
Ewha-18278 |
NADPH-oxidase | Immunology/Inflammation |
APX-115 (Ewha-18278) (Ewha-18278) 是一种有效的,口服活性的,非选择性 Nox 抑制剂,对 Nox1,Nox2 和 Nox4 的 Ki 值分别为 1.08 μM,0.57 μM 和 0.63 μM。APX-115 可有效预防糖尿病小鼠的肾损伤。 | |||
T38646 |
GKT136901 hydrochloride
GKT136901 hydrochloride |
||
GKT136901 hydrochloride is a powerful, selective, and orally active inhibitor of NADPH oxidase (NOX1/4). It exhibits K i values of 160 nM and 165 nM against NOX1 and NOX4, respectively. Additionally, GKT136901 hydrochloride demonstrates selectivity and direct scavenging ability towards peroxynitrite. This compound finds utility in studying diabetic nephropathy, stroke, neurodegeneration, and possesses anti-inflammatory properties. | |||
TP1886 |
NoxA1ds
|
||
Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary | |||
T75949 |
NoxA1ds TFA
|
||
NoxA1ds TFA is a potent and selective inhibitor of NADPH oxidase 1 (NOX1), with an inhibition concentration (IC50) of 20 nM, demonstrating selectivity over NOX2, NOX4, NOX5, and xanthine oxidase. It effectively inhibits NOX1-derived O2- production in HT-29 human colon cancer cells and attenuates VEGF-induced migration of human pulmonary artery endothelial cells under hypoxic conditions in vitro. |