3
27
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T81669 | NKG2D-IN-2 | ||
NKG2D-IN-2(化合物47)为NKG2D抑制剂,其IC50在NKG2D/MICA及ULBP6 TR-FRET测定中分别为0.1 µM与0.2 µM。 | |||
T81670 | NKG2D-IN-1 | ||
NKG2D-IN-1(compound 21)是一种NKG2D抑制剂,其在NKG2D/MICA和ULBP6 TR-FRET测定中的IC50值分别为0.3 µM和0.7 µM。 | |||
T77404 |
Tesnatilimab
IPH-23XX,JNJ-64304500,JNJ 4500 |
Others | Others |
Tesnatilimab 是一种有效的人源化 IgG4 单克隆抗体,可与免疫激活受体 NKG2D 结合。Tesnatilimab 具有潜在的免疫调节和抗炎活性,可用于研究活动性溃疡性结肠炎 。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05414 |
NKG2D/CD314 Protein, Mouse, Recombinant (hFc)
D6H12S2489E,NKG2-D,killer cell lectin-like receptor... |
Mouse | Baculovirus Insect Cells |
NKG2D/CD314 Protein, Mouse, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is O54709-2. | |||
TMPY-00467 |
NKG2D/CD314 Protein, Human, Recombinant (hFc)
D12S2489E,killer cell lectin-like receptor subfamily K, memb... |
Human | CHO Cells |
NKG2D/CD314 Protein, Human, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 46.5 kDa and the accession number is A0A024RAP8. | |||
TMPY-03376 |
NKG2D/CD314 Protein, Rhesus, Recombinant (aa 78-216, His)
NKG2-D,NKG2D,KLRK1,killer cell le... |
Rhesus | Baculovirus Insect Cells |
NKG2D/CD314 Protein, Rhesus, Recombinant (aa 78-216, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 18.3 kDa and the accession number is P61252. | |||
TMPY-03256 |
NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His)
KLR,killer cell lectin-like receptor subfamily K, member 1,D... |
Human | Baculovirus Insect Cells |
NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 18.4 kDa and the accession number is P26718-1. | |||
TMPK-00108 |
NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag)
NKG2D,NKG2-D,CD314,KLR,D12S2489E |
Human | HEK293 Cells |
NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8 alpha beta T cells, gamma δ T cells, NK cells and NKT cells. NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag) is expressed in HEK293 mammalian cells with N-hFc-Flag tag. The predicted molecular weight is 43.4 kDa and the accession numbe... | |||
TMPK-00105 |
NKG2D/CD314 Protein, Human, Recombinant (His & Avi)
NKG2-D,KLR,CD314,NKG2D,D12S2489E |
Human | HEK293 Cells |
NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8 alpha beta T cells, gamma δ T cells, NK cells and NKT cells. NKG2D/CD314 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 19.0 kDa and the accession number ... | |||
TMPK-00106 |
NKG2D/CD314 Protein, Human, Recombinant (His & Avi), Biotinylated
NKG2D,NKG2-D,KLR,CD314,D12S2489E |
Human | HEK293 Cells |
NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8 alpha beta T cells, gamma δ T cells, NK cells and NKT cells. NKG2D/CD314 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 19.0 kDa and the acc... | |||
TMPK-00107 |
NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag), FITC-Labeled
NKG2D,KLR,CD314,D12S2489E,NKG2-D |
Human | HEK293 Cells |
NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8 alpha beta T cells, gamma δ T cells, NK cells and NKT cells. NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag), FITC-Labeled is expressed in HEK293 mammalian cells with N-hFc-Flag tag. The predicted molecular weight is 43.4 kDa and the a... | |||
TMPY-06827 |
NKG2D/CD314 Protein, Human, Recombinant (mFc)
killer cell lectin-like receptor subfamily K, member 1,N... |
Human | Baculovirus Insect Cells |
NKG2D/CD314 Protein, Human, Recombinant (mFc) is expressed in Baculovirus insect cells with mFc tag. The predicted molecular weight is 41.83 kDa and the accession number is P26718-1. | |||
TMPJ-00097 |
NKG2D/CD314 Protein, Cynomolgus, Recombinant (hFc)
member 1,NK cell receptor D,NKG2-D-activating NK re... |
Cynomolgus | HEK293 Cells |
NKG2D/CD314 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-Fc tag. The predicted molecular weight is 50-70 KDa and the accession number is P61252. | |||
TMPJ-00122 |
NKG2D/CD314 Protein, Mouse, Recombinant (His)
KLR,NKG2-D type II integral membrane protein,CD314,... |
Mouse | HEK293 Cells |
NKG2D/CD314 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 20-30 KDa and the accession number is O54709. | |||
TMPK-00136 |
ULBP-2 Protein, Human, Recombinant (His & Avi)
ALCAN-α,RAET1L,NKG2D ligand 2,ALCAN-alpha,... |
Human | HEK293 Cells |
ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity. | |||
TMPK-00137 |
ULBP-2 Protein, Human, Recombinant (His & Avi), Biotinylated
ALCAN-α,NKG2DL2,ULBP2,ALCAN-alpha,ULBP-2/5... |
Human | HEK293 Cells |
ULBP2 expression was however linked to expression of mature CD57() NK cells. In particular, expression of ULBP2 was strongest on those NK cells that had evidence of recent activation and proliferation. We suggest that ULBP2 could be used to identify recently activated "mature" NK cells. | |||
TMPJ-00131 |
NKG2DL Protein, Human, Recombinant (hFc)
ALCAN-β,NKG2DL1,UL16-binding protein 1, |
Human | HEK293 Cells |
NKG2D ligand 1, also called ULBP1, is a member of UL16-binding protein (ULBP) family which has also been termed the retinoic acid early transcript 1 (RAET1) family. Unlike the classical MHC class I molecules and the MIC molecules possess α1, α2 and α3 domains, ULBP/RAET1 family members lack α3 domain. ULBP1 is recognized by the activating receptor NKG2D on the surface of cytotoxic natural killer (NK) and T cells, and then promotes the lysis of cells expressing ULBP1 which is important for the im... | |||
TMPK-00135 |
ULBP-1 Protein, Human, Recombinant (His & Avi), Biotinylated
ALCAN-β,NKG2D ligand 1,ULBP-1,NKG... |
Human | HEK293 Cells |
Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natural killer (NK) cells. ULBP-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.2 kDa and the accession number is Q9BZM6. | |||
TMPK-00134 |
ULBP-1 Protein, Human, Recombinant (His & Avi)
ALCAN-beta,ALCAN-β,ULBP-1,MULT-1,NKG2D lig... |
Human | HEK293 Cells |
Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natural killer (NK) cells. ULBP-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.2 kDa and the accession number is Q9BZM6. | |||
TMPK-00246 |
MICB Protein, Human, Recombinant (His & Avi), Biotinylated
MIC-B,MICB,PERB11.2 |
Human | HEK293 Cells |
MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. MICB Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His... | |||
TMPK-00247 |
MICB Protein, Human, Recombinant (hFc)
MIC-B,PERB11.2,MICB |
Human | HEK293 Cells |
MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. MICB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted ... | |||
TMPK-00245 |
MICB Protein, Human, Recombinant (His & Avi)
PERB11.2,MICB,MIC-B |
Human | HEK293 Cells |
MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. MICB Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The ... | |||
TMPK-00219 |
MICA Protein, Human, Recombinant (His & Avi), Biotinylated
MICA,MGC21250,DAMA-345G11.2,MGC111087,FLJ60820,FLJ36918,PERB... |
Human | HEK293 Cells |
TMICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig‑like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin. | |||
TMPK-00221 |
MICA alpha 3 Protein, Human, Recombinant (mFc)
MICA alpha 3,MICA α 3,MICA,MIC-A |
Human | HEK293 Cells |
MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig‑like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin.. MICA alpha 3 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predi... | |||
TMPY-00575 |
ULBP-6 Protein, Human, Recombinant (His)
RAET1L,retinoic acid early transcript 1L,ULBP6 |
Human | HEK293 Cells |
ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in several human papillomavirus-positive cervical carcinoma cell lines and was inducible on infection with human CMV. Expression of ULBP6 on target cells induced a significant increase in NK-cell killing. ULBP-6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cel... | |||
TMPK-00220 |
MICA Protein, Human, Recombinant (hFc)
MGC111087,FLJ36918,MICA,PERB11.1,DAMA-345G11.2,MGC21250,FLJ6... |
Human | HEK293 Cells |
MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig‑like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin.. MICA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted mol... | |||
TMPK-00218 |
MICA Protein, Human, Recombinant (His & Avi)
FLJ36918,FLJ60820,MICA,MGC111087,PERB11.1,DAMA-345G11.2,MGC2... |
Human | HEK293 Cells |
MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig‑like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin.. MICA Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The pre... | |||
TMPY-00190 |
ULBP-6 Protein, Human, Recombinant (hFc)
retinoic acid early transcript 1L,RAET1L,ULBP6 |
Human | HEK293 Cells |
ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in several human papillomavirus-positive cervical carcinoma cell lines and was inducible on infection with human CMV. Expression of ULBP6 on target cells induced a significant increase in NK-cell killing. ULBP-6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cel... | |||
TMPJ-01212 |
ULBP-1 Protein, Mouse, Recombinant (His)
RAET1I,ULBP1,NKG2DL1 |
Mouse | HEK293 Cells |
Mouse ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or inte... | |||
TMPY-03977 |
DAP10 Protein, Human, Recombinant (mFc)
PIK3AP,DAP10,hematopoietic cell signal transducer,KAP10 |
Human | HEK293 Cells |
HCST (Hematopoietic Cell Signal Transducer, also known as DAP1) is a Protein Coding gene. HCST belongs to the DAP10 family. It is a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. HCST may be part of the immune recognition receptor complex. This receptor plays a major role in triggering cytotoxicity against target cells expressing cell sur... |