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Search Results for " n-ras "

Targets Recommended: Transferase

10

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2678	LB42708	Transferase	Metabolism
	LB42708 是一种口服有活力的特异性法尼基转移酶抑制剂。它对H-Ras、N-Ras 和K-Ras4B 的法尼基化均有抑制作用，其IC50分别为 0.8 nM、1.2 nM 和 2.0 nM。
T6302	Lonafarnib Sarasar,氯那法尼,Sch66336	Raf; Transferase; Autophagy; Ras	Autophagy; GPCR/G Protein; MAPK; Metabolism
	Lonafarnib (Sch66336) 是一种可口服的 FPTase 抑制剂，作用于 H-ras、K-ras 和 N-ras，IC50分别为 1.9 nM、5.2 nM 和 2.8 nM。它具有抗肝炎三角洲病毒的活性。
T9935	UCM-1336 3,3′-(Octylimino)bis[N-phenylpropanamide]	Others	Others
	UCM-1336 (3,3′-(Octylimino)bis[N-phenylpropanamide]) 是一种有效的 ICMT 抑制剂，IC50 为 2 μM，对参与 Ras 翻译后修饰的其他酶具有选择性。
T9533	BC-LI-0186 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide	Others	Others
	BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) 是选择性抑制亮氨酸 tRNA 合成酶与 Ras 相关的 GTP 结合蛋白 D 相互作用(IC50=46.11 nM)。BC-LI-0186能有效抑制肿瘤相关 MTOR 突变体的特性和雷帕霉素耐药癌细胞的生长，能够用于肺癌的相关研究。
T18847	THP-PEG4-Pyrrolidine(N-Me)-CH2OH	Others	Others
	THP-PEG4-Pyrrolidine(N-Me)-CH2OH, a PEG-based PROTAC linker, facilitates the synthesis of PROTAC K-Ras Degrader-1[1].
T72707	(Rac)-Lonafarnib Sch66336 racemate
	(Rac)-Lonafarnib (Sch66336外消旋体) 作为Lonafarnib的外消旋体，属于一种口服有效的法尼基蛋白转移酶 (FPTase) 抑制剂，针对H-ras、K-ras及N-ras展现出杰出的抑制效能，其IC50值分别为1.9 nM、5.2 nM和2.8 nM。此外，Lonafarnib还显示出对抗肝炎三角洲病毒 (HDV) 的潜在活性。
T82136	ICMT-IN-1
	ICMT-IN-1 (化合物75) 作为一种高效的ICMT抑制剂展现出显著活性（IC50=0.0013 μM），能够剂量依赖性地在HCT-116细胞中导致ICMT的胞质内积累，进而有效抑制携带K-Ras和N-Ras变异的多个癌细胞系的增殖。
T18846	THP-PEG4-Pyrrolidine(N-Boc)-CH2OH	Others	Others
	THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a polyethylene glycol (PEG) based PROteolysis TArgeting Chimera (PROTAC) linker, employed for the synthesis of PROTAC K-Ras Degrader-1, as documented in reference [1].
T82086	ICMT-IN-7
	ICMT-IN-7（化合物74）是一种高效的ICMT抑制剂，其IC50值为0.015 μM。该化合物能剂量依赖性地在HCT-116细胞中诱导ICMT蛋白在胞质的积累，并能抑制表达K-Ras和N-Ras的多种癌细胞系的增殖。
T73481	ABD957
	ABD957为一种针对ABHD17家族的去棕榈酰酶有效且选择性的共价抑制剂，其IC50值为0.21 µM。该化合物能够阻止N-Ras信号传递及NRAS突变型AML细胞的生长。

化合物

Cat.No: T2678

Target: Transferase

Cat.No: T6302

Synonym: Sarasar,氯那法尼,Sch66336

Target: Raf, Transferase, Autophagy, Ras

Cat.No: T9935

Synonym: 3,3′-(Octylimino)bis[N-phenylpropanamide]

Target: Others

Cat.No: T9533

Synonym: 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide

Target: Others

THP-PEG4-Pyrrolidine(N-Me)-CH2OH

Cat.No: T18847

Target: Others

(Rac)-Lonafarnib

Cat.No: T72707

Synonym: Sch66336 racemate

Cat.No: T82136

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH

Cat.No: T18846

Target: Others

Cat.No: T82086

Cat.No: T73481

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03487	NRAS Protein, Human, Recombinant (His) NS6,NCMS,CMNS,neuroblast...	Human	E. coli
	NRAS was discovered by researchers at the Institute of Cancer Research, funded by the Cancer Research Campaign (now Cancer Research UK). NRAS gene is a member of the Ras gene family. It is mapped on chromosome 1, and it is activated in HL6, a promyelocytic leukemia line. The mammalian ras gene family consists of the Harvey and Kirsten ras genes (HRAS and KRAS), an inactive pseudogene of each (c-Hras2 and c-Kras1), and the N-ras gene. They differ significantly only in the C-terminal 4 amino acids...
TMPH-01756	Neurofibromin/NF1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. Neurofibromin/NF1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 38.7 kDa and the accession number is P21359.
TMPH-03359	LOX Protein, Rat, Recombinant (His)	Rat	E. coli
	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. LOX Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33.0 kDa and the accession number is P16636.
TMPH-01969	LOX Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. LOX Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 49.0 kDa and the accession number is P28300.
TMPH-01422	GNAS Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. GNAS Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6...
TMPH-03445	GSP1 Protein, S. cerevisiae, Recombinant (His)	Saccharomyces cerevisiae	P. pastoris (Yeast)
	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP is exchanged for bound GDP by RCC1 and inactivated when GTP is hydrolyzed by Ran upon activation by RanGAP1. GSP1 Protein, S. cerevisiae, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.7 kDa and the accession number is P32835.

重组蛋白

NRAS Protein, Human, Recombinant (His)

Cat.No: TMPY-03487

Species: Human

Expression System: E. coli

Neurofibromin/NF1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01756

Species: Human

Expression System: E. coli

LOX Protein, Rat, Recombinant (His)

Cat.No: TMPH-03359

Species: Rat

Expression System: E. coli

LOX Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-01969

Species: Human

Expression System: E. coli

GNAS Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01422

Species: Human

Expression System: E. coli

GSP1 Protein, S. cerevisiae, Recombinant (His)

Cat.No: TMPH-03445

Species: Saccharomyces cerevisiae

Expression System: P. pastoris (Yeast)

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