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Search Results for " n-cadherin "

Targets Recommended: Apoptosis Phosphatase Gamma-secretase Immunology/Inflammation related

7

抑制剂 & 化合物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T13410	ZLDI-8	Apoptosis; Phosphatase; Gamma-secretase; Immunology/Inflammation related	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome; Stem Cells
	ZLDI-8 是 Notch 激活/裂解酶 ADAM-17 的抑制剂，可抑制 Notch 蛋白裂解，并降低促存活/抗凋亡和上皮-间质转化相关蛋白的表达。它还是竞争性不可逆酪氨酸磷酸酶抑制剂，以IC50为 5.32 μM 抑制 MHCC97-H 细胞的生长。
T3144	BML-284 Wnt agonist 1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	BML-284 (Wnt agonist 1) 是细胞通透性 Wnt 信号激活剂，能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
T8820	BML-284 hydrochloride BML-284 HCL,Wnt agonist 1 HCL	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	BML-284 hydrochloride (Wnt agonist 1 HCL) 是细胞通透性 Wnt 信号激活剂。它能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
T1608	ADH-1 trifluoroacetate Exherin trifluoroacetate	Dehydrogenase	Metabolism
	ADH-1 trifluoroacetate (Exherin trifluoroacetate) 是一种选择性的、竞争性N-钙粘蛋白拮抗剂，具有潜在抗肿瘤和抗血管生成作用。
T2637	ADH-1 Exherin	Dehydrogenase	Metabolism
	ADH-1 (Exherin) 是N-cadherin 的拮抗剂，对 N-cadherin 介导的细胞黏附具有抑制作用。
T81058	SWELYYPLRANL-NH2 TFA
	SWELYYPLRANL-NH2 TFA 作为E-cadherin和N-cadherin的拮抗剂，显示出对噬菌体克隆与E-或N-cad/Fc嵌合蛋白结合的有效抑制作用，IC50分别为0.7和0.09 μM。此化合物亦能阻碍细胞聚集，有助于促进药物穿越上皮和内皮的渗透性屏障。
T81059	SWELYYPLRANL-NH2
	SWELYYPLRANL-NH2 是一种分别针对E-cadherin和N-cadherin的拮抗剂，能够有效抑制噬菌体克隆与E-或N-cad/Fc嵌合蛋白的结合，其IC50值分别为0.7和0.09 μM。此外，该化合物还可抑制细胞聚集现象，并能促进药物透过上皮和内皮的渗透性屏障，以便于药物递送。

化合物

Cat.No: T13410

Target: Apoptosis, Phosphatase, Gamma-secretase, Immunology/Inflammation related

Cat.No: T3144

Synonym: Wnt agonist 1

Target: Wnt/beta-catenin

BML-284 hydrochloride

Cat.No: T8820

Synonym: BML-284 HCL,Wnt agonist 1 HCL

Target: Wnt/beta-catenin

ADH-1 trifluoroacetate

Cat.No: T1608

Synonym: Exherin trifluoroacetate

Target: Dehydrogenase

Cat.No: T2637

Synonym: Exherin

Target: Dehydrogenase

SWELYYPLRANL-NH2 TFA

Cat.No: T81058

SWELYYPLRANL-NH2

Cat.No: T81059

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01143	N Cadherin Protein, Human, Recombinant (His) CDHN,CDw325,NCAD,CD325,cadherin 2...	Human	HEK293 Cells
	N Cadherin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.5 kDa and the accession number is A0A024RC42.
TMPY-03703	N Cadherin Protein, Mouse, Recombinant Ncad,N-cadherin,CDHN,cad...	Mouse	HEK293 Cells
	N Cadherin Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 29 kDa and the accession number is P15116.
TMPK-00695	N Cadherin Protein, Human, Recombinant (hFc) CDHN,Neural cadherin,CDH2,N	Human	HEK293 Cells
	Neural (N)-cadherin is a calcium-dependent single-chain transmembrane glycoprotein that mediates homotypic and heterotypic cell-cell adhesion. As an important member of the cadherin family, N-cadherin plays an important role in the developmental and functional regulation of the nervous system, brain, heart, skeletal muscles, blood vessels and hematopoietic microenvironment.
TMPY-03692	N Cadherin Protein, Human, Recombinant (His & hFc) cadherin 2, type 1, N-cadherin (<...	Human	HEK293 Cells
	N Cadherin Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 35.2 kDa and the accession number is A0A024RC42.
TMPY-01172	CDH12 Protein, Human, Recombinant (His) CDHB,cadherin 12, type 2 (N-cadherin	Human	HEK293 Cells
	Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic binding partners, catenins. The cadherin/catenin adhesion system plays key roles in the morphogenesis and function of the vertebrate and invertebrate nervous systems. Furthermore, this system is involved in synaptic plasticity. Recent studies on the role of individual cadherin subt...
TMPJ-01267	CDH11 Protein, Human, Recombinant (His) Cadherin 11 Type 2 OB-Cadherin (Osteoblast...	Human	HEK293 Cells
	Cadherin-11 is a type II classical cadherin member of the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells, and thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in the brain. Mature cadherin proteins consists of a large N-terminal extracellular domain, a single membrane-spanning domain, and...
TMPJ-01266	CDH11 Protein, Human, Recombinant (hFc & His) OSF-4,Osteoblast cadherin,CDH11,Cadherin-1...	Human	HEK293 Cells
	Cadherin-11, also known as OSF-4, Osteoblast cadherin and CDH11, is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells, may thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in brain. Mature cadherin proteins consists of a large N-terminal extracellular doma...
TMPY-01052	R-Cadherin/CDH4 Protein, Human, Recombinant (His) R-CAD,cadherin 4, type 1, R-cadherin (reti...	Human	HEK293 Cells
	The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) regions and cytoplasmic domains, that is: classical cadherins, desmosomal cadherins, protocadherins, and cadherin-like molecules. Human cadherin 4, type 1, R-cadherin (retinal), also known as CDH4, CAD4 and RCAD, is a classical cadherin from the cadherin superfamily. It is a calcium-de...
TMPH-00331	ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc) Adhesin 3,3D9 antigen,Aggluti...	Candida albicans	E. coli
	Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. ALS3 Prot...
TMPK-00800	CDH3 Protein, Mouse, Recombinant (His) HJMD,CDHP,CAD3,P-cadherin,Placental cadher...	Mouse	HEK293 Cells
	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The ...
TMPK-01306	CDH3 Protein, Cynomolgus, Recombinant (His) PCAD,CDHP,CAD3,Placental cadherin,HJMD,Cad...	Cynomolgus	HEK293 Cells
	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag....
TMPK-00851	CDH3 Protein, Human, Recombinant (aa 108-654, His) CAD3,Placental cadherin,PCAD,HJMD,CDH3,P-c...	Human	HEK293 Cells
	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Human, Recombinant (aa 108-654, His) is expressed in HEK293 mammalian cells with C-H...
TMPH-03103	CDH3/Cadherin 3 Protein, Pig, Recombinant (His) Placental cadherin,CDH3,Cadherin-...	Sus scrofa (Pig)	P. pastoris (Yeast)
	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH3/Cadherin 3 Protein, Pig, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 17.6 kDa and the accession number is O18926.
TMPH-03104	CDH3/Cadherin 3 Protein, Pig, Recombinant (His & SUMOstar) P-cadherin,Placental cadherin,CDH...	Sus scrofa (Pig)	P. pastoris (Yeast)
	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH3/Cadherin 3 Protein, Pig, Recombinant (His & SUMOstar) is expressed in yeast with N-6xHis-SUMOSTAR tag. The predicted molecular weight is 31.6 kDa and the accession number is O18926.
TMPH-01218	DSP Protein, Human, Recombinant (His & SUMO) Desmoplakin,DSP,DP,250/210 kDa paraneoplas...	Human	E. coli
	Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. DSP Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 42.1 kDa and the accession number is P15924.
TMPH-02539	MGAT3 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition,...

重组蛋白

N Cadherin Protein, Human, Recombinant (His)

Cat.No: TMPY-01143

Species: Human

Expression System: HEK293 Cells

N Cadherin Protein, Mouse, Recombinant

Cat.No: TMPY-03703

Species: Mouse

Expression System: HEK293 Cells

N Cadherin Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00695

Species: Human

Expression System: HEK293 Cells

N Cadherin Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-03692

Species: Human

Expression System: HEK293 Cells

CDH12 Protein, Human, Recombinant (His)

Cat.No: TMPY-01172

Species: Human

Expression System: HEK293 Cells

CDH11 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01267

Species: Human

Expression System: HEK293 Cells

CDH11 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-01266

Species: Human

Expression System: HEK293 Cells

R-Cadherin/CDH4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01052

Species: Human

Expression System: HEK293 Cells

ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc)

Cat.No: TMPH-00331

Species: Candida albicans

Expression System: E. coli

CDH3 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00800

Species: Mouse

Expression System: HEK293 Cells

CDH3 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01306

Species: Cynomolgus

Expression System: HEK293 Cells

CDH3 Protein, Human, Recombinant (aa 108-654, His)

Cat.No: TMPK-00851

Species: Human

Expression System: HEK293 Cells

CDH3/Cadherin 3 Protein, Pig, Recombinant (His)

Cat.No: TMPH-03103

Species: Sus scrofa (Pig)

Expression System: P. pastoris (Yeast)

CDH3/Cadherin 3 Protein, Pig, Recombinant (His & SUMOstar)

Cat.No: TMPH-03104

Species: Sus scrofa (Pig)

Expression System: P. pastoris (Yeast)

DSP Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01218

Species: Human

Expression System: E. coli

MGAT3 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02539

Species: Mouse

Expression System: E. coli

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