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Search Results for " ms2 "

Targets Recommended: Others

11

抑制剂 & 化合物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7263	SMS2-IN-2 SMS2 inhibitors	Others	Others
	SMS2-IN-2 (SMS2 inhibitors) 是一种具有高度选择性、口服具有活力的鞘磷脂合成酶 2 抑制剂，能够作用于 SMS2 (IC50:100 nM)和 SMS1 (IC50:56 nM)。它可减轻慢性炎症反应。
T4696	BMS202 hydrochloride (1675203-84-5(free base)) PD-1/PD-L1 inhibitor 2 hydrochloride	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS202 hydrochloride (1675203-84-5(free base)) (PD-1/PD-L1 inhibitor 2 hydrochloride) 是一种小分子 PD-1/PD-L1 相互作用抑制剂 (IC50: 18 nM)。生物物理研究表明 BMS202 直接与 PD-L1 结合。 BMS202 的结合促进 PD-L1 二聚化并阻断 PD-L1/PD1 相互作用。
T5828	MS21570 5-(苄基硫代)-N-甲基-1,3,4-噻二唑-2-胺	GPR	Endocrinology/Hormones; GPCR/G Protein
	MS21570 作为 GPR171 拮抗剂基于其阻断能力，IC50 为 220 nM，可减少小鼠的焦虑样行为和恐惧条件反射。
T67746	IMS2186	Others	Others
	IMS2186 是一种抗脉络膜新生血管 (CNV) 试剂，可以使癌细胞周期阻滞在 G2/M 期，由此产生抗增殖和抗血管生成作用。IMS2186 能够减少眼睛渗漏和病变细胞的数量，并且无眼内毒性。
T28114	MS2177 MS 2177,MS-2177
	MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). MS2177 has an in vitro IC50 of 1.9 μM (σ = 1.05 μM, n = 4) in ascintillation proximity assay. Binding of MS2
T71922	MS2734
	MS2734 is a novel Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT).
T24501	MS2126 NSC 71584,NSC71584,MS 2126,MS-2126,NSC-71584
	MS2126 is a Human p53 and CREB Binding Protein interaction inhibitor.
T33511	ms2i6A ms2i6-2-6,ms2i6 2 6
	ms2i6A is a mitochondrial tRNA-specific modification, which regulates efficient mitochondrial translation and energy metabolism in mammals.
T39929	MS21
	MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.
T26846	BMS270394 BMS 189961,BMS-270394,BMS 270394
	BMS270394 is an agonist of nuclear retinoic acid receptor (RAR-γ).
T12938	SMS2-IN-1	Others	Others
	SMS2-IN-1 是一种有效且具有高选择性的鞘磷脂合成酶 2 (SMS2) 抑制剂， IC50 为 6.5 nM，Kd 为 37 nM。SMS2-IN-1 对 SMS2 的选择性比 SMS1 (IC50 为 1000 nM) 多 150 倍。

化合物

Cat.No: T7263

Synonym: SMS2 inhibitors

Target: Others

BMS202 hydrochloride (1675203-84-5(free base))

Cat.No: T4696

Synonym: PD-1/PD-L1 inhibitor 2 hydrochloride

Target: PD-1/PD-L1

Cat.No: T5828

Synonym: 5-(苄基硫代)-N-甲基-1,3,4-噻二唑-2-胺

Target: GPR

Cat.No: T67746

Target: Others

Cat.No: T28114

Synonym: MS 2177,MS-2177

Cat.No: T71922

Cat.No: T24501

Synonym: NSC 71584,NSC71584,MS 2126,MS-2126,NSC-71584

Cat.No: T33511

Synonym: ms2i6-2-6,ms2i6 2 6

Cat.No: T39929

Cat.No: T26846

Synonym: BMS 189961,BMS-270394,BMS 270394

Cat.No: T12938

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00933	ADAM8/CD156a Protein, Mouse, Recombinant (His) CD156a,MGC134985,ADAM 8,Ms2,Adam8	Mouse	HEK293 Cells
	A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/...
TMPK-00918	ADAM8/CD156a Protein, Human, Recombinant (aa 17-655, His) CD156a,ADAM 8,MGC134985,Adam8,Ms2	Human	HEK293 Cells
	A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/...
TMPY-05532	ADAM8/CD156a Protein, Human, Recombinant (His) CD156,MS2,CD156a,ADAM metallopeptidase dom...	Human	HEK293 Cells
	ADAM8/CD156a Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is Q14C66.
TMPH-00756	Capsid Protein, Escherichia phage MS2, Recombinant (His & Myc) CP,Capsid protein,Coat protein	Escherichia phage MS2	E. coli
	Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 26 nm in diameter, and consisting of 89 capsid proteins dimers (178 capsid proteins). Involved in viral genome encapsidation through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome. The capsid contains also 1 copy of the A2 maturation protein.; Acts as a translational repressor of viral replicase synthesis late in infection. This latter function is th...
TMPY-01113	SGMS2 Protein, Human, Recombinant (mFc) SMS2,sphingomyelin synthase 2	Human	HEK293 Cells
	SGMS2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 35.7 kDa and the accession number is A0A024RDH4.

重组蛋白

ADAM8/CD156a Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00933

Species: Mouse

Expression System: HEK293 Cells

ADAM8/CD156a Protein, Human, Recombinant (aa 17-655, His)

Cat.No: TMPK-00918

Species: Human

Expression System: HEK293 Cells

ADAM8/CD156a Protein, Human, Recombinant (His)

Cat.No: TMPY-05532

Species: Human

Expression System: HEK293 Cells

Capsid Protein, Escherichia phage MS2, Recombinant (His & Myc)

Cat.No: TMPH-00756

Species: Escherichia phage MS2

Expression System: E. coli

SGMS2 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-01113

Species: Human

Expression System: HEK293 Cells

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