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Search Results for " mmp3 "

Targets Recommended: MMP

21

抑制剂 & 化合物

2

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12082	MMP3 inhibitor 1	MMP	Proteases/Proteasome
	MMP3 inhibitor 1 is a potent and highly selective inhibitor of MMP-3 (IC50 of 1 nM).
T37048	MMP-3 Inhibitor	MMP	Proteases/Proteasome
	MMP-3 Inhibitor 是一种多肽基质金属蛋白酶-3（MMP-3）抑制剂，Ki 值为 95 nM。MMP-3 inhibitor 具有抗癌抗肿瘤活性。
T37048L	MMP-3 Inhibitor acetate MMP-3 Inhibitor acetate(158841-76-0 Free base)	MMP	Proteases/Proteasome
	MMP-3 Inhibitor acetate 是一种细胞渗透性强的人 MMP-3 抑制剂.
T12539L	Prinomastat KB-R9896,普啉司他,AG3340	MMP	Proteases/Proteasome
	Prinomastat inhibits MMP-2, MMP-3 and MMP-9 (Kis: 0.05 nM, 0.3 nM and 0.26 nM, respectively). Prinomastat crosses the blood-brain barrier. It also has antitumor activity. Prinomastat is a broad-spectrum, potent, orally active metalloproteinase inhibitor (
T14322	ARP-100 MMP-2 Inhibitor III	MMP	Proteases/Proteasome
	ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM)，MMP-3 (4.5 μM)，MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1＇口袋相互作用，并在体外对基质胶的侵袭模型中显示抗侵袭特性。
T12414	PF-00356231 hydrochloride	MMP	Proteases/Proteasome
	PF-00356231 hydrochloride 是基质金属蛋白酶 MMP-12 的抑制剂，IC50 为 1.4 μM。
T6011	Batimastat 巴马司他,BB94	MMP	Proteases/Proteasome
	Batimastat (BB94) 是广谱MMP 抑制剂，能够抑制MMP-1 (IC50:3 nM)，MMP-2 (IC50:4 nM)，MMP-9 (IC50:4 nM)，MMP-7 (IC50:6 nM) 和 MMP-3 (IC50:20 nM)。
T36712	BPHA MMP-2/MMP-9 Inhibitor II	MMP	Proteases/Proteasome
	BPHA (MMP-2/MMP-9 Inhibitor II) 是一种有效的、具有选择性和口服活性的抑制剂，对MMP-2、MMP-9 和 MMP-14 具有抑制作用，IC50 分别为 12 nM、16 nM 和 17 nM。BPHA 不抑制 MMP-1、-3 和 -7 (IC50 分别为 974、>1000 和 795 nM)。BPHA 具有抗血管生成和抗肿瘤活性。
T20563	PD-166793 PD-166793-0000,PD 166793,PD166793	MMP	Proteases/Proteasome
	PD-166793是一种具有口服活性、有效性和选择性的 MMP 抑制剂，对 MMP-2，MMP-3 和 MMP-13 具有抑制作用。PD-166793 在大鼠心力衰竭模型中改善心肌缺血和再灌注损伤。
T41079	MMP13-IN-2 MMP13-IN-2
	MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.
T10461	Batimastat sodium salt BB-94 sodium salt	MMP	Proteases/Proteasome
	Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3).
T13358	XL-784	MMP	Proteases/Proteasome
	XL-784 is a selective inhibitor of matrix metalloproteinases (MMP)(IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).
T16986	Tanomastat BAY 12-9566	MMP	Proteases/Proteasome
	Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively.
T17201	UK 356618	MMP	Proteases/Proteasome
	UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).
T15015	CTS-1027 RS 130830,Ro 1130830	Others	Others
	CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has > 1,000 fold selectivity over MMP1.
T22685	CP-471474 CP 471474	Others	Others
	Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.
T13357	XL-784 free base	Others	Others
	XL-784 free base is a selective inhibitor of matrix metalloproteinases (MMP), (IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).
T13249	UK-370106	MMP	Proteases/Proteasome
	UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50: 320 nM).
T10817	Cipemastat Ro 32-3555	Others	Others
	Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).
T31063	CP-544439 UNII-516DO4KL5R
	CP-544439 is an inhibitor of matrix metalloproteinase-13, which has an effect on adipose tissue development.
T36492	CMC2.24
	CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis throug...

化合物

MMP3 inhibitor 1

Cat.No: T12082

Target: MMP

MMP-3 Inhibitor

Cat.No: T37048

Target: MMP

MMP-3 Inhibitor acetate

Cat.No: T37048L

Synonym: MMP-3 Inhibitor acetate(158841-76-0 Free base)

Target: MMP

Cat.No: T12539L

Synonym: KB-R9896,普啉司他,AG3340

Target: MMP

Cat.No: T14322

Synonym: MMP-2 Inhibitor III

Target: MMP

PF-00356231 hydrochloride

Cat.No: T12414

Target: MMP

Cat.No: T6011

Synonym: 巴马司他,BB94

Target: MMP

Cat.No: T36712

Synonym: MMP-2/MMP-9 Inhibitor II

Target: MMP

Cat.No: T20563

Synonym: PD-166793-0000,PD 166793,PD166793

Target: MMP

Cat.No: T41079

Synonym: MMP13-IN-2

Batimastat sodium salt

Cat.No: T10461

Synonym: BB-94 sodium salt

Target: MMP

Cat.No: T13358

Target: MMP

Cat.No: T16986

Synonym: BAY 12-9566

Target: MMP

Cat.No: T17201

Target: MMP

Cat.No: T15015

Synonym: RS 130830,Ro 1130830

Target: Others

Cat.No: T22685

Synonym: CP 471474

Target: Others

XL-784 free base

Cat.No: T13357

Target: Others

Cat.No: T13249

Target: MMP

Cat.No: T10817

Synonym: Ro 32-3555

Target: Others

Cat.No: T31063

Synonym: UNII-516DO4KL5R

Cat.No: T36492

Cat. No.	Product Name	Target	Signaling Pathways
T3850	Luteolin 7-O-glucuronide Luteolin-7-glucuronide,木犀草素-7-O-葡萄糖醛酸苷	MMP	Proteases/Proteasome
	Luteolin 7-O-glucuronide (Luteolin-7-glucuronide) 是一种自由基清除剂，能够抑制基质金属蛋白酶的活性，其对 MMP-1，MMP-3，MMP-8，MMP-9，MMP-13的IC50值分别为 17.63，7.99，11.42，12.85，0.03 μM。
T5S1026	Apigenin-7-glucuronide Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸	MMP	Proteases/Proteasome
	Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) 能够抑制基质金属蛋白酶的活性，其对 MMP-3 (IC50:12.87 μM)，MMP-8 (IC50:22.39 μM)，MMP-9 (IC50:17.52 μM)，MMP-13 (IC50:0.27 μM)。

天然产物

Luteolin 7-O-glucuronide

Cat.No: T3850

Synonym: Luteolin-7-glucuronide,木犀草素-7-O-葡萄糖醛酸苷

Target: MMP

Apigenin-7-glucuronide

Cat.No: T5S1026

Synonym: Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸

Target: MMP

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00447	MMP-3 Protein, Human, Recombinant (His) Transin-1,Stromelysin-1,MMP-3,Matrix metal...	Human	HEK293 Cells
	MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. The MMP-3 enzyme degrades collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 c...
TMPY-02689	MMP-3 Protein, Human, Recombinant STMY,MMP-3,matrix metallopeptidase 3	Human	E. coli
	Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in the extracellular matrix. This prot...

重组蛋白

MMP-3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00447

Species: Human

Expression System: HEK293 Cells

MMP-3 Protein, Human, Recombinant

Cat.No: TMPY-02689

Species: Human

Expression System: E. coli

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