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11
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Cat. No. | Product Name | Target | Signaling Pathways |
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T79088 |
Chlamydia pneumoniae-IN-1
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Chlamydia pneumoniae-IN-1 (compound 55),一种抗衣原体的苯并咪唑类化合物,对肺炎衣原体具有高度抑制作用,在10 μM 浓度下能够抑制99%的肺炎衣原体生长,并对宿主细胞的活力产生95%的抑制效果。此外,Chlamydia pneumoniae-IN-1 对CV-6菌株亦显示出明显的抗菌活性,其最小抑菌浓度(MIC)为12.6 μM。 | |||
T38240 |
2,6-Dichlorodiphenylamine
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Antibacterial | Microbiology/Virology |
2,6-Dichlorodiphenylamine 是双氯芬酸钠的一种结构类似物,显示出抗白色念珠菌活性。2,6-Dichlorodiphenylamine 是非选择性抗炎剂,为COX 的抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50分别为 4 和 1.3 nM。 | |||
T40304 |
Antitubercular agent-10
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Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM. | |||
T80294 |
GLK-19
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GLK-19是一种具抗大肠杆菌活性的抗菌肽(MIC: 10 μM)。 | |||
T71449 |
Capreomycin free base
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Capreomycin is a polypeptide antibiotic originally isolated from S. capreolus. It is active against M. tuberculosis (MIC = 10 µg/ml). Capreomycin binds to both the 30S and 50S ribosomal subunits, inhibiting protein synthesis. | |||
T23955 | Dactylfungin B | ||
Dactylfungins B is a novel antifungal antibiotic produced by Dactylaria Parvispora. The antibiotics were active against Candida pseudotropicalis and other fungi, with a MIC value of fewer than 10 micrograms/ml. | |||
T23954 |
Dactylfungin A
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Dactylfungins A is a novel antifungal antibiotic produced by Dactylaria Parvispora. The antibiotics were active against Candida pseudotropicalis and other fungi, with a MIC value of fewer than 10 micrograms/ml. | |||
T80377 |
Xenopsin precursor fragment
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Parasite | Microbiology/Virology |
Xenopsin precursor fragment 为抗菌肽,展现抗菌/抗真菌(MIC: 10-500 μg/mL)及抗原虫(MIC: 2-20 μg/mL)效能。 | |||
T80407 |
Peptide 5g
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Peptide 5g 是一种具有广谱抗菌特性的化合物。它对 E. coli, S. aureus 和 C. albicans 的最小抑制浓度 (MIC) 值显著,分别为 30 μg/mL、10 μg/mL 和 12.5 μg/mL。 | |||
T63512 |
LpxC-IN-10
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LpxC-IN-10 是一种选择性的 LpxC 抑制剂,对 E. coli 和 K. pneumoniae 的 MIC 值为0.5 μg/mL,能够用于研究细菌感染。 | |||
T83065 |
Antifungal agent 85
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Antifungalagent 85 (compound 24f)是一种抗真菌剂,对多种革兰氏阳性菌表现出良好的活性,其最小抑制浓度(MIC)范围为2.5 - 10?μM。 | |||
T80368 |
Im5
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Im5 是一种具有针对 Escherichia coli、Staphylococcus aureus、Bacillus subtilis 的抗菌活性(MIC:10、2.5-5、0.5-1 μM)的抗菌肽,同时表现出溶血性(EC50: 28 μM)。 | |||
T79440 |
DprE1-IN-5
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DprE1-IN-5(Compound 10)为一种DprE1抑制剂,对Mtb H37Rv菌株表现出抗结核活性(MIC: 4 μM),并对耐药菌株具有抗分枝杆菌效果,同时展现出较高的微粒体稳定性。 | |||
T38289 |
Leucomycin A13
Leucomycin A13 |
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Leucomycin A13 is a macrolide antibiotic and a component of the leucomycin complex originally isolated from S. kitasatoensis. It is active against B. subtilis, S. aureus, M. luteus, and E. coli with MIC values of 0.16, 0.16, 0.08 and >10 μg/ml, respectively. It binds to ribosomes with an IC50 value of 1.2 μM in a radioligand binding assay. | |||
T36475 |
TunR2
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TunR2 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis(MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. Unlike tunicamycin, TunR2 is non-toxic toS. cerevisiae(MIC = >10 μg/ml) and does not inhibit glycosylation in a protein N-glycosylation assay. TunR2 also has reduced antiproliferative activity against MDA-MB-231 and CHO cells compared wi... | |||
T62592 |
(R)-Gyramide A hydrochloride
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(R)-Gyramide A hydrochloride 是一种细菌 DNA 促旋酶 (bacterial DNA gyrase) 抑制剂,能够破坏超螺旋活性 (IC50: 875 μM)。(R)-Gyramide A hydrochloride 对绿脓杆菌大肠杆菌表现出抗菌活性,其值为 MIC 为 10-80μM。(R)-Gyramide A hydrochloride 不影响密切相关的酶拓扑异构酶 IV。 | |||
T37723 |
IT-143A
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IT-143A is a bacterial metabolite originally isolated fromStreptomycessp. IT-143.1It is active against the bacteriumM. luteus(MIC = 6.25 μg/ml) and the fungiA. fumigatusandT. rubrumin vitro(MICs = 12.5-25 μg/ml). 1.Urakawa, A., Sasaki, T., Yoshida, K., et al.IT-143-A and B, novel piericidin-group antibiotics produced by Streptomyces SpJ. Antibiot. (Tokyo)49(10)1052-1055(1996) | |||
T70642 |
Lanopepden camsylate
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Lanopepden, also known as GSK-1322322 or GSK-322, is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. GSK1322322 represents a valuable alternative therapy for the trea... | |||
T80286 |
TP4 (Nile tilapia piscidin)
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Necroptosis | Apoptosis |
TP4(Nile tilapia piscidin)是一种piscidin样的抗菌肽,其口服活性被证实。此化合物对多种革兰氏阳性及阴性菌株均有效(MIC: 0.03-10 μg/mL),并展现了溶血性。TP4还能增强免疫响应、提升抗氧化能力和改善肠道健康,助于防御细菌感染。除此之外,TP4显示抗肿瘤效果,并可通过激发癌细胞线粒体功能障碍导致坏死(necrosis)。 | |||
T36539 |
Nocardamine
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Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lo... | |||
T35453 |
β-Defensin-4 (human) (trifluoroacetate salt)
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β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and pro... | |||
T36659 |
Boromycin
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Boromycin is a boron-containing macrolide antibiotic that has been found in Streptomyces. Boromycin inhibits growth of B. subtilis (MIC = 0.05 μg/ml) and induces efflux of potassium ions from B. subtilis without affecting Na+/K+-ATPase activity. It decreases the synthesis of protein, RNA, and DNA in B. subtilis when used at a concentration of 0.05 μg/ml. It inhibits the growth of B. halodurans (MIC = 10 ng/ml) and inhibits the futalosine pathway of menaquinone synthesis in B. halodurans. Boromyc... | |||
T32669 |
Leucomycin a5
Leukomycin A5,Turimycin H4 |
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Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not against K. pneumoniae, S. typhimuriu | |||
T37713 |
Funalenone
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Funalenone is a phenalenone originally isolated from A. niger. It inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M(a); IC50 = 1.7 μM) but is less cytotoxic to mammalian HPB-M(a) cells (IC50 = 87 μM). Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 μM. It also inhibits... | |||
T79240 |
DNA gyrase B-IN-2
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DNA gyrase B-IN-2 (Compound E) 是一款基于2-aminobenzothiazole的DNA gyrase B抑制剂,针对ESKAPE病原体显示出强效活性。该化合物在低纳摩尔浓度下表现出优异的DNA gyrase B抑制能力(IC50< 10 nM),具备对多种ESKAPE病原体的广谱抗菌作用。对于大部分革兰氏阳性菌,最低抑菌浓度(MIC)低于0.03 μg/mL;针对革兰氏阴性病原体如E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa和Klebsiella pneumoniae,MIC为4 - 16 μg/mL。此化合物适用于感染性疾病的研究应用。 | |||
T36409 |
Roccellic Acid
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Roccellic acid is a lichen secondary metabolite that has been found in R. montagnei and has antibacterial and anticancer activities.1,2 It is active against the bacteria S. gordonii and P. gingivalis (MIC = 46.9 μg/ml for both).1 Roccellic acid (100 μg/ml) inhibits proliferation of MDA-MB-231, MCF-7, and DLD-1 cancer cells by 65.3, 75.8, and 87.9%, respectively.2 |1. Sweidan, A., Chollet-Krugler, M., Sauvager, A., et al. Antibacterial activities of natural lichen compounds against Streptococcus ... | |||
T38009 |
Kocurin
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Kocurin is a thiazolyl peptide originally isolated fromK. palustrisand has antibiotic activity.1It is active against methicillin-resistantS. aureus(MRSA; MIC = 0.25 μg/ml), as well asB. subtilisandE. faeciumin a solid agar test when used at a concentration of 8 μg/ml. Kocurin is also active againstE. faecium,E. faecalis,S. epidermidis, and clinical isolates of vancomycin-resistant enterococci (MICs = 0.004-1.025 μg/ml).2In vivo, kocurin (2.5, 5, and 10 mg/ml) increases survival in a mouse model ... | |||
T37880 |
OPC-167832
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OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. OPC-167832 exhibits very low MICs against laboratory strains of M. tuberculosis H37Rv (MIC: 0.0005 μg/ml) and Kurono (MIC: 0.0005 μg/ml) and strains with monoresistance to rifampin (RIF), isoniazid (INH), ethambutol (EMB), streptomycin (STR), and pyrazinamide (PZA) (MIC: 0.00024-0.001 ... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN4883 |
Quinine sulfate dihydrate
奎宁树 |
Others | Others |
Quinine sulfate dihydrate 在钾通道阻滞剂中起主要作用。它也被用作抗疟疾、抗胆碱能、抗高血压和降糖药。它抑制线粒体atp 调节的钾通道。它也被用来研究生物结晶血红素,血红素,在疟疾寄生虫的代谢和研究血红素(FP)复合物的毒性。 | |||
TN3260 |
8(14),15-Isopimaradien-3-ol
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Calcium Channel; Antifection | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
ent-8(14),15-pimaradien-3beta-ol (8(14),15-Isopimaradien-3-ol) can induce vascular relaxation. It displays high antibacterial activities (MIC values lower than 10 microg /mL for most pathogens). | |||
TN4594 |
Murraol
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Antifection | Microbiology/Virology |
Murraol shows the significant proliferative activities on osteoblast-like UMR106 cells lines at the concentration of 1 × 10-10 mol/L. It and auraptenol show 63 ug/mL MIC value against Klebsiella pneumoniae ATCC 4352 and Bacillus subtilis ATCC 9372. | |||
T80335 |
Maximin H3
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Maximin H3,源自中华红腹蟾蜍Bombina maxima皮肤分泌,为一种抗菌肽。对Escherichia coli ATCC 25922、Staphylococcus aureus ATCC 2592、Bacillus pyocyaneus CMCC B1010 及Candida albicans ATCC 2002表现出显著抗性,其MIC值依次为20, 10, 20, 5 μg/ml。 | |||
TN1099 |
Dihydroevocarpine
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MAO; P-gp; Antifection | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it shows more potent inhibitory effects against MAO-B compared to MAO-A. | |||
T75697 | 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone | ||
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone,为喹诺酮类生物碱,作用为二酰基甘油酰基转移酶抑制剂与血管紧张素II受体阻断剂,其IC50值依次为20.1 μM与34.1 μM。此化合物亦展现对幽门螺杆菌的有效抗活性,MIC值达10 μg/mL。 | |||
TN4148 | Glyasperin C | Tyrosinase; Antifection | Microbiology/Virology; Proteases/Proteasome |
Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candidate in the design of skin-whitening agents. Glyasperin C shows potent anti-vancomycin-resistant | |||
T35483 |
19,20-Epoxycytochalasin D
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19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM. | |||
TN6674 |
Cyclo-(Pro-Gly)
Cyclo(Pro-Gly) |
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Cyclo(Pro-Gly) is an active metabolite of piracetam-N-phenylacetyl-L-prolylglycine (GWS-111), it shows a greater resistance to an enzymatic effect than natural neuropeptides. Cyclo-(Gly-Pro) shows cytotoxicity at the concentration of 10 umol/L, it inhibit | |||
T35409 |
(+)-δ-Cadinene
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Apoptosis; Antibacterial | Apoptosis; Microbiology/Virology |
(+)-δ-Cadinene 是一种从G. hirsutum 中发现的倍半萜,具有抗菌、杀虫、抗癌和抗增殖活性。 它对肺炎双球菌的MIC 值为31.25 μg/ml,对 A. stephensi、A. aegypti 和 C. quinquefasciatust 三龄幼虫的LC50s 值分别8.23、9. 2和3。(+)-δ-Cadinene(10、50 和 100 μM)可诱导 OVCAR-3 人类卵巢癌细胞凋亡并抑制其增殖。 | |||
T35741 |
Gliovirin
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Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease... |
Cat. No. | Product Name | Species | Expression System |
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TMPY-01431 |
L1CAM Protein, Human, Recombinant (His)
N-CAM-L1,MASA,HSAS,L1 cell adhesion molecule,MIC5,N... |
Human | HEK293 Cells |
L1CAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 125 kDa and the accession number is P32004-1. | |||
TMPK-00811 |
L1CAM Protein, Mouse, Recombinant (His)
CALL,MGC132578,FLJ44930,NCAM-L1,MIC5,CHL-1,SPG1,HSA... |
Mouse | HEK293 Cells |
L1 cell adhesion molecule (L1CAM) is one of the first neural adhesion molecules described with important functions in the development of the nervous system. Subsequent work discovered that L1CAM is expressed in many human cancers and is often associated with bad prognosis. This is most likely due to the motility and invasion promoting function of L1CAM. L1CAM is a valuable diagnostic/prognostic marker and an attractive target for the therapy of several human cancers. | |||
TMPK-00532 |
CD46 Protein, Cynomolgus, Recombinant (His)
CD46,MCP,TLX,MIC10,AHUS2,TRA2.10 |
Cynomolgus | HEK293 Cells |
CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'. CD46 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cel... | |||
TMPY-02023 |
CD46 Protein, Human, Recombinant (His)
AHUS2,MIC10,CD46 molecule, complement regu... |
Human | HEK293 Cells |
CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic... | |||
TMPK-00570 |
CD46 Protein, Canine, Recombinant (His)
CD46,AHUS2,TRA2.10,LOC609365,TLX,MCP,MIC |
Canine | HEK293 Cells |
CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'. CD46 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells w... | |||
TMPY-06857 |
L1CAM Protein, Human, Recombinant (hFc)
N-CAM-L1,NCAM-L1,N-CAML1,MASA,HSAS,CAML1,CD171,SPG1,L1 cell ... |
Human | HEK293 Cells |
L1CAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 149.93 kDa and the accession number is NP_000416.1. | |||
TMPY-06759 |
L1CAM Protein, Human, Recombinant (His & Avi), Biotinylated
CAML1,SPG1,MIC5,HSAS,N-CAM-L1,L1 cell adhesion mole... |
Human | HEK293 Cells |
L1CAM Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 126.46 kDa and the accession number is NP_000416.1. | |||
TMPY-01751 |
DR3/TNFRSF25 Protein, Human, Recombinant (hFc)
TRAMP,TR3,WSL-1,TNFRSF12,DR3,WSL-LR,tumor necrosis factor re... |
Human | HEK293 Cells |
DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10. | |||
TMPY-00961 |
ADAM15 Protein, Human, Recombinant (His)
MDC15,ADAM metallopeptidase domain 15 |
Human | HEK293 Cells |
ADAM15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is Q13444-10. | |||
TMPY-02300 |
BIN1 Protein, Human, Recombinant (His)
AMPHL,bridging integrator 1,AMPH2,SH3P9 |
Human | E. coli |
Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased... | |||
TMPY-05760 |
DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated
TRAMP,tumor necrosis factor receptor superfamily, member 25,... |
Human | HEK293 Cells |
DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10. |