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Search Results for " mgl "

Targets Recommended: Thyroid hormone receptor(THR)

17

抑制剂 & 化合物

2

天然产物

1

TargetMol 试剂盒

7

重组蛋白

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Cat. No.	Product Name	Form	Specificity Of Inhibition
CL0103	mGluR agonist/antagonist/modulator kit mGluR agonist/antagonist/modulator kit

TargetMol 试剂盒

mGluR agonist/antagonist/modulator kit

Cat.No: CL0103

Cat. No.	Product Name	Target	Signaling Pathways
T3595	Resmetirom VIA-3196,MGL3196	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Resmetirom (VIA-3196) 是一种高度选择性的THR-β激动剂(EC50:0.21 μM)。
T7688	4-Nonylphenylboronic acid	FAAH	Metabolism; Neuroscience
	4-Nonylphenylboronic acid 是 FAAH 的抑制剂。
T12717	Basimglurant CTEP Derivative,RG7090	GluR	Neuroscience
	Basimglurant (CTEP Derivative) 是一种高效，选择性，可口服的 mGlu5负变构调节剂，Kd 值为1.1 nM。
T9970	mGluR3 modulator-1 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile,1-乙基-3-(1,4-氧杂氮杂环己-4-基)-5,6,7,8-四氢异喹啉-4-甲腈	GluR	Neuroscience
	mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) 是 mGluR3 的正变构调节剂，可用于治疗帕金森病的研究。
T74287	MGlc-DAG
	MGlc-DAG 是一种糖脂甘油酯，可用于合成药物递送化合物。
T61775	mGlu4 receptor agonist 1
	mGlu4 receptor agonist 1 (compound 62) is a highly effective positive allosteric modulator of mGlu4 receptors, displaying an EC 50 of 308 nM. Additionally, it exhibits noteworthy anxiolytic and antipsychotic properties [1].
T61277	mGluR2 modulator 4
	mGluR2 modulator 4 (compound 47) is a highly potent positive allosteric modulator of mGluR2, exhibiting an EC 50 value of 0.8 μM. It holds the potential for investigating antipsychotic properties [1].
T81801	mGluR5 antagonist-1
	mGluR5 antagonist-1，一种高亲和力的mGluR5拮抗剂，其IC50为11.5 nM，表现出抗抑郁活性。
T38910	mGluR2 antagonist 1
	mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, with an IC50 value of 9 nM. Furthermore, it exhibits excellent permeability across the blood-brain barrier, making it a promising candidate for central nervous system-related studies or therapies.
T60882	mGluR2 modulator 2
	mGluR2 modulator 2 (compound 2) 可用于抗精神病药物研究。mGluR2 modulator 2 是一种有效的、选择性和口服生物可利用的mGluR2正变构调节剂，EC50值为 0.13 μM。
T62202	mGluR2 modulator 1
	mGluR2 modulator 1 (compound 95) 是一种有效的、具有血脑屏障通透性的 mGluR2 (代谢型谷氨酸受体-2)正向变构调节剂 (EC50: 0.03 μM)。mGluR2 modulator 1 能够用于研究精神病。
T38659	mGluR5 modulator 1
	mGluR5 modulator 1 is a compound that acts as a positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Its primary application lies in the field of schizophrenia and cognitive impairment research.
T3591	URB602	Lipase; Antibacterial	Metabolism; Microbiology/Virology
	URB602 是选择性单酰基甘油脂肪酶 (MGL) 抑制剂，非竞争性抑制大鼠脑 MGL，IC50为 28±4 μM。
T28165	NF-1819 NF 1819,NF1819	Lipase	Metabolism
	NF-1819 是一种高效、选择性的不可逆 MGL (β-内酰胺基单酰甘油脂肪酶)抑制剂。NF-1819 在体内多发性硬化症模型中缓解疾病症状，在体内急性炎性疼痛模型中表现出镇痛作用。NF-1819 具有较高的膜通透性和血脑屏障通透性。
T34521	SAR629 SAR 629,SAR-629
	SAR-629 is an MGL inhibitor or 2-AG degradation inhibitor.
T71493	AM6580
	AM6580 is an irreversible monoacylglycerol lipase (MGL) inhibitor.
T61294	Monoacylglycerol lipase inhibitor 1
	Monoacylglycerol lipase inhibitor 1 是一种有效的单酰基甘油脂肪酶 (MGL) 抑制剂 (化合物 13)。

化合物

Cat.No: T3595

Synonym: VIA-3196,MGL3196

Target: Thyroid hormone receptor(THR)

4-Nonylphenylboronic acid

Cat.No: T7688

Target: FAAH

Cat.No: T12717

Synonym: CTEP Derivative,RG7090

Target: GluR

mGluR3 modulator-1

Cat.No: T9970

Synonym: 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile,1-乙基-3-(1,4-氧杂氮杂环己-4-基)-5,6,7,8-四氢异喹啉-4-甲腈

Target: GluR

Cat.No: T74287

mGlu4 receptor agonist 1

Cat.No: T61775

mGluR2 modulator 4

Cat.No: T61277

mGluR5 antagonist-1

Cat.No: T81801

mGluR2 antagonist 1

Cat.No: T38910

mGluR2 modulator 2

Cat.No: T60882

mGluR2 modulator 1

Cat.No: T62202

mGluR5 modulator 1

Cat.No: T38659

Cat.No: T3591

Target: Lipase, Antibacterial

Cat.No: T28165

Synonym: NF 1819,NF1819

Target: Lipase

Cat.No: T34521

Synonym: SAR 629,SAR-629

Cat.No: T71493

Monoacylglycerol lipase inhibitor 1

Cat.No: T61294

Cat. No.	Product Name	Target	Signaling Pathways
T5737	euphol	Others; Lipase; Endogenous Metabolite	Metabolism; Others
	Euphol 是从Euphorbia tirucalli 的汁液中分离出来的四环三萜醇，具有抗炎和免疫调节作用，口服具有活力。它通过能够逆机制抑制单酰基甘油脂肪酶 (MGL) 的特性，IC50=315 nM。外周 MGL 抑制能够调节内源性大麻素系统从而阻止炎症性疼痛的发展。
T4S1050	Pristimerin 扁塑藤素,Celastrol methyl ester	NF-κB; Antibacterial	Microbiology/Virology; NF-κB
	Pristimerin (Celastrol methyl ester) 是一种可逆的单酰基甘油脂肪酶高效抑制剂，IC50值为93 nM。

天然产物

Cat.No: T5737

Target: Others, Lipase, Endogenous Metabolite

Cat.No: T4S1050

Synonym: 扁塑藤素,Celastrol methyl ester

Target: NF-κB, Antibacterial

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02971	CLEC10A Protein, Human, Recombinant (hFc) HML2,CD301,CLECSF13,HML,MGL,C-type lectin domain fa...	Human	HEK293 Cells
	CLEC10A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is Q8IUN9-2.
TMPY-02459	CLEC10A Protein, Mouse, Recombinant (hFc) Mgl1,C-type lectin domain family 10, member A,CD301...	Mouse	HEK293 Cells
	CLEC10A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.7 kDa and the accession number is F8WHB7.
TMPY-02405	CLEC10A Protein, Mouse, Recombinant (His) C-type lectin domain family 10, member A,Mgl1,M...	Mouse	HEK293 Cells
	CLEC10A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.7 kDa and the accession number is F8WHB7.
TMPJ-01217	Mgl2 Protein, Mouse, Recombinant (His) Macrophage Galactose-type C-lectin 2,Mgl2,CD301b,Ma...	Mouse	HEK293 Cells
	Macrophage galactose N-acetyl-galactosamine-specific lectin 2(Mgl2), also known as CD301b, is a 38 kDa member that belongs to the C-type lectin family. Two MGL proteins are encoded by separate genes in the mouse, but share 91% amino acid (aa) identity in the extracellular domain (ECD). Only one MGL occurs in human and rat and this MGL is structurally more similar to mouse MGL1 than MGL2. However, human MGL and mouse MGL2 both bind specifically to terminal GalNAc residues, in contrast with mouse...
TMPH-03337	MGLL Protein, Rat, Recombinant (His)	Rat	P. pastoris (Yeast)
	Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. MGLL Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.8 kDa and the accession nu...
TMPH-03475	MglB Protein, Salmonella typhimurium, Recombinant (His)	Salmonella typhimurium	P. pastoris (Yeast)
	This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor. MglB Protein, Salmonella typhimurium, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 35.4 kDa and the accession number is P23905.
TMPJ-00201	CLEC10A Protein, Human, Recombinant (His) HML,C-Type Lectin Domain Family 10 Member A,CLECSF14,CLEC10A...	Human	HEK293 Cells
	C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. It constitute a unique class of C-type lectins b...

重组蛋白

CLEC10A Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02971

Species: Human

Expression System: HEK293 Cells

CLEC10A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02459

Species: Mouse

Expression System: HEK293 Cells

CLEC10A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02405

Species: Mouse

Expression System: HEK293 Cells

Mgl2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01217

Species: Mouse

Expression System: HEK293 Cells

MGLL Protein, Rat, Recombinant (His)

Cat.No: TMPH-03337

Species: Rat

Expression System: P. pastoris (Yeast)

MglB Protein, Salmonella typhimurium, Recombinant (His)

Cat.No: TMPH-03475

Species: Salmonella typhimurium

Expression System: P. pastoris (Yeast)

CLEC10A Protein, Human, Recombinant (His)

Cat.No: TMPJ-00201

Species: Human

Expression System: HEK293 Cells

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