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26

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
TP1997L	[Ala17]-MCH acetate [Ala17]-MCH acetate(359784-84-2 free base)	Melanin-concentrating Hormone Receptor (MCHR)	GPCR/G Protein
	[Ala17]-MCH acetate 是 MCHR1 的选择性配体，Ki 为 0.16 nM，Kd 为 0.37 nM（Eu3+ 螯合物标记）。 [Ala17]-MCH acetate 对 MCHR2 具有选择性，Ki 为 34 nM。
TP1996	MCH(human, mouse, rat) MCH (human, mouse, rat),黑色素聚集激酶素(MCH)( 大鼠)	GPR; Melanin-concentrating Hormone Receptor (MCHR)	Endocrinology/Hormones; GPCR/G Protein
	MCH(human, mouse, rat) 是MCH-R 肽激动剂，对 CHO 细胞系中 MCH-2R 高度敏感，激活 MCH-1R 和 MCH-2R 的IC50 值分别为 0.3 和 1.5 nM，EC50值对分别为 3.9 和 0.1 nM。
T13101	TC-MCH 7c	Melanin-concentrating Hormone Receptor (MCHR)	GPCR/G Protein
	TC-MCH 7c 是一种可口服的、可选择的、可穿透血脑屏障的MCH1R 拮抗剂，其对hMCH1R 的IC50表现为5.6 nM，TC-MCH 7c 是一种苯基吡啶酮衍生物，其对人的MCH1R Ki 分别为 3.4 nM ，对小鼠 MCH1R Ki 为 3.0 nM。
TP1104L	Melanin Concentrating Hormone, salmon acetate MCH (salmon),Melanin Concentrating Hormone, salmon acetate(87218-84-6 free base)	Others; Melanin-concentrating Hormone Receptor (MCHR)	GPCR/G Protein; Others
	Melanin Concentrating Hormone, salmon acetate (MCH (salmon))(87218-84-6 free base) 是一种 19 个氨基酸的环状肽，主要在下丘脑中表达。
TP1997	[Ala17]-MCH
	Potent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54 nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34 nM respectively).
TP1102	MCH (salmon) TFA (87218-84-6 free base) Melanin Concentrating Hormone, salmon TFA,MCH (salmon) TFA
	Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus. Melanin Concentrating Hormone is implicated in the control of general arousal and goal-orientated behaviours in mammals, and appears to be a key
T11964	MCH-1 antagonist 1	P450	Metabolism
	MCH-1 antagonist 1 also inhibits CYP3A4 (IC50: 10μM).MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist (Ki: 2.6 nM).
TP1104	Melanin Concentrating Hormone, salmon MCH (salmon)
	Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus.
T75845	[Ala17]-MCH TFA
	[Ala17]-MCH TFA 是一种 MCH 的类似物，是 MCHR1的配体 (Ki=0.16 nM) 选择性优于对 MCHR2的 (Ki=34 nM)。Eu3+螯合标记 [Ala17]-MCH 对 MCHR1(Kd=0.37 nM) 亲和性高，而对 MCHR2的亲和性低。
T75846	MCH(human, mouse, rat) TFA
	MCH (human, mouse, rat) TFA 是一种有效的 MCH-R 的肽激动剂，与 MCH1R 和 MCH2R 结合的 IC50值分别为 0.3 nM 和 1.5 nM。MCH (human, mouse, rat) 对 CHO 细胞系中 MCH-2R 高度敏感，通过 FLIPR 监测细胞内钙动员，显示出功能性激活 MCH-1R 和 MCH-2R 的EC50值对分别为 3.9 nM 和 0.1 nM。
T76632	(Phe13,Tyr19)-MCH (human, mouse, rat)
	(Phe13,Tyr19)-MCH (human, mouse, rat) 作为一种高效的 SLC-1 与 S643b 受体配体，可充当这两种受体的激动剂。
T7294	Aramchol C20-FABAC	Others	Others
	Aramchol (C20-FABAC) 是一种胆酸和花生酸的结合物，能够降低硬脂酰辅酶 A 去饱和酶 1 (SCD1) 的活性。它具有用于非酒精性脂肪性肝病 (NAFLD) 和非酒精性脂肪性肝炎 (NASH) 的潜能。
T11966	MCHR1 antagonist 2	HER; Melanin-concentrating Hormone Receptor (MCHR)	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	MCHR1 antagonist 2 是有效的黑色素聚集激素受体 1 拮抗剂，IC50为 65 nM。它也抑制hERG，在IMR-32 细胞中的IC50为 4.0 nM。
T38450	Ac-hMCH(6-16)-NH2 Ac-hMCH(6-16)-NH2
	Ac-hMCH(6-16)-NH2 shows non-selective agonist activity towards both MCH-1R and MCH-2R, which are human MCH receptors in the brain. The compound effectively binds to and activates these receptors, with IC 50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R, respectively.
T29956	Amchem R 14 R14,Polyurethane Y-195,R-14
	Amchem R 14 is a biochemical.
T40896	Bromchlorbuterol hydrochloride
	Bromchlorbuterol hydrochloride is a potent β-adrenergic agonist (β-agonist) compound commonly employed in the investigation of pulmonary conditions such as pulmonary disease and asthma.
T11965	MCHR1 antagonist 3	Others	Others
	MCHR1 antagonist 3, a potent antagonist of the melanin-concentrating hormone receptor-1 (MCHR1), is employed for the regulation of energy metabolism.
T10173	MCHR1 antagonist 1	Others	Others
	MCHR1 antagonist 1 is a selective antagonist of melanin-concentrating hormone-1 (MCH1) receptor (Kb: 1 nM, Ki: 4 nM at human MCH1).
T76640	hMCH-1R antagonist 1
	hMCH-1R antagonist 1 (Compound 30)为高效且具有选择性的hMCHR1拮抗剂，KB值仅为3.6 nM。它与hMCHR1和hMCHR2的结合能力强，IC50值分别为65 nM与49 nM，主要用于代谢研究领域。
TP1578L	Neuropeptide EI, rat acetate Neuropeptide EI, rat acetate(125934-45-4 free base)	Melanocortin Receptor; Melanin-concentrating Hormone Receptor (MCHR)	GPCR/G Protein; Neuroscience
	Neuropeptide EI, rat acetate(125934-45-4 free base) 在不同的行为范例中显示功能性 MCH 拮抗剂和 MSH 激动剂活性。
T9968	3-Piperidinyl(1-pyrrolidinyl)methanone hydrochloride	Others	Others
	3-Piperidinyl(1-pyrrolidinyl)methanone hydrochloride 可用于合成 MCH-R1 拮抗剂 piperidin-4-yl-urea 衍生物。
T8004	SNAP 94847 hydrochloride	GPR; Melanin-concentrating Hormone Receptor (MCHR)	Endocrinology/Hormones; GPCR/G Protein
	SNAP 94847 hydrochloride 是一种选择性黑色素浓缩激素受体1 拮抗剂，Ki 为 2.2 nM，具有抗抑郁样活性。它是 MCH 诱发的肌醇磷酸形成的高亲和力拮抗剂，pA2为 7.81。
T15450	GW-803430 GW-3430	Others	Others
	GW-803430 is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH R1) (pIC50: 9.3). GW-803430 is orally active in an animal model of obesity.
TP1578	Neuropeptide EI, rat
	Displays functional MCH-antagonist and MSH-agonist activity in different behavioral paradigms.
T7749	ALB-127158
	ALB-127158(a) 是一种有效的选择性黑色素浓缩激素 1 (MCH1) 受体拮抗剂，可能是炎症性肠病 (IBD) 的潜在治疗方法
T75970	Melanin Concentrating Hormone, salmon TFA
	Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是在硬骨鱼的垂体中发现的 19 个氨基酸组成的神经肽，它调节食物摄入，能量平衡，睡眠状态和心血管系统。Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是 SLC-1/GPR24和 MCHR2的配体。

化合物

[Ala17]-MCH acetate

Cat.No: TP1997L

Synonym: [Ala17]-MCH acetate(359784-84-2 free base)

Target: Melanin-concentrating Hormone Receptor (MCHR)

MCH(human, mouse, rat)

Cat.No: TP1996

Synonym: MCH (human, mouse, rat),黑色素聚集激酶素(MCH)( 大鼠)

Target: GPR, Melanin-concentrating Hormone Receptor (MCHR)

Cat.No: T13101

Target: Melanin-concentrating Hormone Receptor (MCHR)

Melanin Concentrating Hormone, salmon acetate

Cat.No: TP1104L

Synonym: MCH (salmon),Melanin Concentrating Hormone, salmon acetate(87218-84-6 free base)

Target: Others, Melanin-concentrating Hormone Receptor (MCHR)

Cat.No: TP1997

MCH (salmon) TFA (87218-84-6 free base)

Cat.No: TP1102

Synonym: Melanin Concentrating Hormone, salmon TFA,MCH (salmon) TFA

MCH-1 antagonist 1

Cat.No: T11964

Target: P450

Melanin Concentrating Hormone, salmon

Cat.No: TP1104

Synonym: MCH (salmon)

[Ala17]-MCH TFA

Cat.No: T75845

MCH(human, mouse, rat) TFA

Cat.No: T75846

(Phe13,Tyr19)-MCH (human, mouse, rat)

Cat.No: T76632

Cat.No: T7294

Synonym: C20-FABAC

Target: Others

MCHR1 antagonist 2

Cat.No: T11966

Target: HER, Melanin-concentrating Hormone Receptor (MCHR)

Ac-hMCH(6-16)-NH2

Cat.No: T38450

Synonym: Ac-hMCH(6-16)-NH2

Cat.No: T29956

Synonym: R14,Polyurethane Y-195,R-14

Bromchlorbuterol hydrochloride

Cat.No: T40896

MCHR1 antagonist 3

Cat.No: T11965

Target: Others

MCHR1 antagonist 1

Cat.No: T10173

Target: Others

hMCH-1R antagonist 1

Cat.No: T76640

Neuropeptide EI, rat acetate

Cat.No: TP1578L

Synonym: Neuropeptide EI, rat acetate(125934-45-4 free base)

Target: Melanocortin Receptor, Melanin-concentrating Hormone Receptor (MCHR)

3-Piperidinyl(1-pyrrolidinyl)methanone hydrochloride

Cat.No: T9968

Target: Others

SNAP 94847 hydrochloride

Cat.No: T8004

Target: GPR, Melanin-concentrating Hormone Receptor (MCHR)

Cat.No: T15450

Synonym: GW-3430

Target: Others

Neuropeptide EI, rat

Cat.No: TP1578

Cat.No: T7749

Melanin Concentrating Hormone, salmon TFA

Cat.No: T75970

Cat. No.	Product Name	Target	Signaling Pathways
T6323	Oligomycin A MCH 32,寡霉素A	ATPase; Antibiotic; Antifungal	Membrane transporter/Ion channel; Microbiology/Virology
	Oligomycin A (MCH 32) 是从链霉菌属中得到的一种线粒体F0F1-ATPase 抑制剂，抑制氧化磷酸化和线粒体偶联膜上发生的所有 ATP 依赖性过程。

天然产物

Cat.No: T6323

Synonym: MCH 32,寡霉素A

Target: ATPase, Antibiotic, Antifungal

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