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Cat. No.	Product Name	Target	Signaling Pathways
T14856	Calcipotriol MC 903,卡泊三醇,Calcipotriene
	Calcipotriol (MC 903) 是一种合成的 VitD3类似物，对维他命 D 受体具有高亲和力。
T8485	THIQ	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	THIQ 是一种选择性黑皮质素 4 受体 (MC4R) 激动剂，对 hMC4R 和 rMC4R 的 IC50 分别为 1.2 和 0.6 nM。
TP1898	HS024 HS 024	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	HS024 是一种选择性的MC4受体拮抗剂，可增加食物摄入，对 MC4、MC5、MC3 和 MC1 的Ki 分别为 0.29、3.29、5.45 和 18.6 nM。
TP1889	MCL0020 MCL 0020	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	MCL0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂，IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症，在体内表现出抗焦虑样活性。
T5464	JNJ-10229570 JNJ10229570,UNII-N9IX402L35,JNJ 10229570	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	JNJ-10229570 (UNII-N9IX402L35) 是肾上腺皮质受体 1 和肾上腺皮质受体 5 的拮抗剂，可抑制皮脂腺分化和皮质特异性脂质的产生，其抑制125I-NDP-α-MSH 和人类细胞中 MC1R 和 MC5R 结合的IC50值分别为 270 nM 和 200 nM。
T7589	Afamelanotide acetate afamelanotide	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Afamelanotide acetate 是一种合成的 α-黑素细胞刺激激素类似物和一流的黑皮质素-1 受体激动剂，用于治疗红细胞生成性原卟啉症。
T7608	Bremelanotide Acetate bremelanotide,PT-141 Acetate	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Bremelanotide Acetate (PT-141 Acetate) 是 α-MSH 的合成肽类似物，是黑素皮质素受体 MC3R 和 MC4R 的激动剂，有用于性功能障碍的研究潜力。
TP1097	Melanotan I 美拉诺坦,美拉诺坦 I,[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I	Others	Others
	Melanotan I 是一种非特异性黑素皮质激素受体 (MCR) 激动剂，是一种 α- 黑素细胞刺激激素 (α-MSH) 类似物，皮下注射可增加黑色素在皮肤中的含量。Melanotan I 可用于辅助美黑。Melanotan I 可用于预防阳光诱发皮肤癌，可用于研究黑色素瘤和男性勃起功能障碍。
T7813	α-MSH MSH, amide,CZEN-002,美拉诺坦,α-Melanocyte-Stimulating Hormone (MSH), amide	Melanocortin Receptor; Adenylyl cyclase	GPCR/G Protein; Neuroscience
	α-MSH (MSH, amide) 是一种内源性神经肽，是一种内源性黑皮质素受体 4 (MC4R) 激动剂，具有抗炎和解热活性。
T7769	Nonapeptide-1 Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5	Others	Others
	Nonapeptide-1 (Melanostatine™ 5) 可以抑制黑色素的合成，这使得它对治疗某些皮肤病很感兴趣。
T7627	Adrenocorticotropic Hormone (ACTH) (4-10), human Adrenocorticotropic Hormone (ACTH) (4-10),ACTH (4-10), human,Acth (4-10)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Adrenocorticotropic Hormone (ACTH) (4-10), human 是黑皮质素 4 型受体 (melanocortin 4 receptor, MC4R) 激动剂。
T12946	SNT-207858	Others	Others
	SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
T12945	SNT-207858 free base	Others	Others
	SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor).
T12944	SNT-207707	Others	Others
	SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor).
T10230	MC-4R Agonist 1	Others	Others
	MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R) and can be used in the research of sexual dysfunction, obesity, and diabetes.
T39088	Mc-Dexamethasone
	Mc-Dexamethasone is a drug-linker conjugate for ADC . Mc-Dexamethasone is made toxin Dexamethasone conjugated to the non-cleavable MC linker. Dexamethasone is a glucocorticoid receptor agonist.
T10568	BMS-470539 dihydrochloride	Others	Others
	BMS-470539 dihydrochloride is a highly potent and selective agonist of the melanocortin-1 receptor (MC-1R; IC50: 120 nM; EC50: 28 nM) with anti-inflammatory properties. It does not activate MC-3R and is a very weak partial agonist at MC-4R and MC-5R.
T29030	U-101958 Maleate U101958,U-101958,U 101958
	U-101958 Maleate is a ligand of dopamine D4 receptor. U-101958 Maleate also binds to a large sigma1 receptor-like component in SK-N-MC neuroblastoma cells and human cerebellum with high affinity.
T79090	Bivamelagon MC-4R Agonist 2	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	MC-4R Agonist 2 (实施例 1)作为MC4R激动剂，适用于肥胖、糖尿病、炎症及勃起功能障碍的研究领域。
T77875	Mc-Val-Cit-PAB-Gefitinib chloride
	Mc-Val-Cit-PAB-Gefitinibchloride是一种担载EGFR酪氨酸激酶抑制剂Gefitinib的ADC活性分子连接子偶联物，由Gefitinib和专为ADC设计的连接子Mc-Val-Cit-PAB构成。
T76644	Acetyl-ACTH (4-24) (human, bovine, rat)
	Acetyl-ACTH (4-24) (human, bovine, rat) 是原黑色素皮质素 (POMC) 肽的片段。POMC 肽，如促肾上腺皮质激素(ACTH)，是α-MSH 的前体，也是 MC-1受体的激动剂。
T76642	Acetyl-ACTH (2-24) (human, bovine, rat)
	Acetyl-ACTH (2-24) (human, bovine, rat) 是原黑色素皮质素 (POMC) 肽的片段。POMC 肽，如促肾上腺皮质激素(ACTH)，是α-MSH 的前体，也是MC-1受体的激动剂。
TP1532	γ-2-MSH (41-58), amide
	Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cells. Most of the cells responding to
T76643	Acetyl-ACTH (3-24) (human, bovine, rat)
	Acetyl-ACTH (3-24) (human, bovine, rat) 是原黑色素皮质素 (POMC) 肽的片段。POMC 肽，如促肾上腺皮质激素(ACTH)，是α-MSH 的前体，也是 MC-1 受体的激动剂。
T76303	(p-Iodo-Phe7)-ACTH (4-10)
	'(p-Iodo-Phe7)-ACTH (4-10)'为垂体前腺产生和分泌的肾上腺皮质激素(ACTH)衍生物，担任黑素皮质素(MC)受体拮抗剂角色，能够抑制α-黑素细胞刺激激素(α-MSH)引发的大鼠过度梳理行为。
T36427	PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)	PACAP	GPCR/G Protein
	Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors on SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 24.5, 106, and 105 nM, respectively) and inhibits cAMP accumulation induced by PACAP (1-38) (Kis = 457, 102, and 283 nM, respectively, in SH-SY5Y, ...

化合物

Cat.No: T14856

Synonym: MC 903,卡泊三醇,Calcipotriene

Cat.No: T8485

Target: Melanocortin Receptor

Cat.No: TP1898

Synonym: HS 024

Target: Melanocortin Receptor

Cat.No: TP1889

Synonym: MCL 0020

Target: Melanocortin Receptor

Cat.No: T5464

Synonym: JNJ10229570,UNII-N9IX402L35,JNJ 10229570

Target: Melanocortin Receptor

Afamelanotide acetate

Cat.No: T7589

Synonym: afamelanotide

Target: Melanocortin Receptor

Bremelanotide Acetate

Cat.No: T7608

Synonym: bremelanotide,PT-141 Acetate

Target: Melanocortin Receptor

Cat.No: TP1097

Synonym: 美拉诺坦,美拉诺坦 I,[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I

Target: Others

Cat.No: T7813

Synonym: MSH, amide,CZEN-002,美拉诺坦,α-Melanocyte-Stimulating Hormone (MSH), amide

Target: Melanocortin Receptor, Adenylyl cyclase

Cat.No: T7769

Synonym: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5

Target: Others

Adrenocorticotropic Hormone (ACTH) (4-10), human

Cat.No: T7627

Synonym: Adrenocorticotropic Hormone (ACTH) (4-10),ACTH (4-10), human,Acth (4-10)

Target: Melanocortin Receptor

Cat.No: T12946

Target: Others

SNT-207858 free base

Cat.No: T12945

Target: Others

Cat.No: T12944

Target: Others

MC-4R Agonist 1

Cat.No: T10230

Target: Others

Mc-Dexamethasone

Cat.No: T39088

BMS-470539 dihydrochloride

Cat.No: T10568

Target: Others

U-101958 Maleate

Cat.No: T29030

Synonym: U101958,U-101958,U 101958

Cat.No: T79090

Synonym: MC-4R Agonist 2

Target: Melanocortin Receptor

Mc-Val-Cit-PAB-Gefitinib chloride

Cat.No: T77875

Acetyl-ACTH (4-24) (human, bovine, rat)

Cat.No: T76644

Acetyl-ACTH (2-24) (human, bovine, rat)

Cat.No: T76642

γ-2-MSH (41-58), amide

Cat.No: TP1532

Acetyl-ACTH (3-24) (human, bovine, rat)

Cat.No: T76643

(p-Iodo-Phe7)-ACTH (4-10)

Cat.No: T76303

PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)

Cat.No: T36427

Target: PACAP

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