Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Calcipotriol (MC 903) 是一种合成的 VitD3类似物,对维他命 D 受体具有高亲和力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 233 | 现货 | ||
5 mg | ¥ 538 | 现货 | ||
10 mg | ¥ 788 | 现货 | ||
25 mg | ¥ 1,450 | 现货 | ||
50 mg | ¥ 2,880 | 现货 | ||
100 mg | ¥ 4,270 | 现货 |
产品描述 | Calcipotriol (MC 903) is a synthetic VitD3 analogue. Which has a high affinity for the vitamin D receptor. |
体外活性 | Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM), when NHEK cells are not stimulated with IL-17A or IL-22. The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20, and 40 nM in a dose-dependent manner [1]. Treatment of natural killer (NK) cells with drugs modulate their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH)2D3, Calcipotriol or FTY720 for 4 h. All three concentrations of Calcipotriol, 1,25(OH)2D3, and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation [2]. |
体内活性 | Compare with placebo, the weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002). Survival is equally distributed between the groups. One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived [3]. |
别名 | MC 903, 卡泊三醇, Calcipotriene |
分子量 | 412.6 |
分子式 | C27H40O3 |
CAS No. | 112965-21-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (242.37 mM)
Ethanol: 50 mg/mL (121.18 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 2.4237 mL | 12.1183 mL | 24.2365 mL | 60.5914 mL |
5 mM | 0.4847 mL | 2.4237 mL | 4.8473 mL | 12.1183 mL | |
10 mM | 0.2424 mL | 1.2118 mL | 2.4237 mL | 6.0591 mL | |
20 mM | 0.1212 mL | 0.6059 mL | 1.2118 mL | 3.0296 mL | |
50 mM | 0.0485 mL | 0.2424 mL | 0.4847 mL | 1.2118 mL | |
100 mM | 0.0242 mL | 0.1212 mL | 0.2424 mL | 0.6059 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Calcipotriol 112965-21-6 MC 903 Vitamin D receptor inhibit MC-903 VD/VDR Vitamin D 卡泊三醇 Inhibitor MC903 Calcipotriene inhibitor