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Targets Recommended: Glucagon Receptor

15

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T63166	LSN3318839 LSN-3318839,LSN 3318839	Glucagon Receptor	GPCR/G Protein
	LSN3318839 是一种有效且可口服的胰高血糖素样肽-1受体（GLP-1R）变构调节剂。LSN3318839可增强GLP-1R的G蛋白偶联信号传导，可用来降低血糖。
T63166L	(S, R)-LSN 3318839 (S, R)-LSN 3318839(Isomer-2764704-18-7)	Glucagon Receptor	GPCR/G Protein

T27854	LSN2463359 LSN-2463359,LSN 2463359	GluR	Neuroscience
	LSN2463359是 mGlu5受体的正变构调节剂。
T11884	LSN 3213128	Others	Others
	LSN 3213128, anti-tumor activity. is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells.
T27855	LSN2814617 LSN-2814617,LSN 2814617
	LSN2814617 是一种口服有效的、能透过血脑屏障的和选择性的mGlu5(代谢性谷氨酸 5) 正向别构调节剂 (PAM)，其EC50值为 52 nM (Human mGlu5) 和 42 nM (rat mGlu5)。体内EGG 研究表明，LSN2814617 具有显著的促醒作用，并且几乎不会反弹过度嗜睡，可用于精神分裂症研究。
T32687	Leustroducsin B LSN B
	Leustroducsin B is a novel colony-stimulating factor (CSF) inducer extracted from Streptomyces platensis SANK 60191.
T36967	LSN3106729 hydrochloride
	LSN3106729 hydrochloride, the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. LSN3106729 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1]. [1]. Edward S. Kim, et al. Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non-Small Cell Lung Cancer: A Phase Ib Study. [2]. Nathanael Gray, et al. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods o...
T32686	Leustroducsin A LSN A
	Leustroducsin A is an inducer of colony-stimulating factors (CSFs) extracted from Streptomyces platensis SANK 60191.
T4376	Nampt-IN-1 LSN3154567	c-Fms; NAMPT; CSF-1R	Metabolism; Tyrosine Kinase/Adaptors
	Nampt-IN-1 (LSN3154567) 是选择性的 NAMPT 抑制剂，能够抑制纯化的 NAMPT，IC50=3.1 nM。
T32904	LSN3172176 Precursor LSN-3172176 Precursor,LSN 3172176 Precursor
	LSN3172176 Precursor is a precursor for 11C-radiolabelling LSN3172176 PET scan.
T32688	Leustroducsin C LSN C
	Leustroducsin C is an inducer of colony-stimulating factors CSF extracted from Streptomyces platensis SANK 60191.
T10220	LSN2839567 Abemaciclib metabolite M2	CDK	Cell Cycle/Checkpoint
	LSN2839567 (Abemaciclib metabolite M2) 是 Abemaciclib 的活性代谢物，是一种强效的 CDK4 和 CDK6 抑制剂（IC50s：1-3 nM），具有抗癌活性。LSN2839567 抑制 CDK9。LSN2839567 以浓度依赖性方式抑制细胞生长和细胞周期进程，可用于研究乳腺癌和肺癌。
T10738	Abemaciclib metabolite M20 CDK4/6-IN-4,LSN3106726	CDK	Cell Cycle/Checkpoint
	Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。
T75112	LSN3160440
	LSN3160440 是GLP-1R 的变构调节剂，可作为蛋白-蛋白相互作用（PPI）的稳定剂或分子胶，协助无活性GLP-1 (9-36) NH2粘附在GLP-1R 上。
T76470	GVLSNVIGYLKKLGTGALNAVLKQ
	GVLSNVIGYLKKLGTGALNAVLKQ 是一种具有 24 个氨基酸的抗菌肽。 GVLSNVIGYLKKLGTGALNAVLKQ 可能形成 α 螺旋。GVLSNVIGYLKKLGTGALNAVLKQ (PGQ) 对革兰氏阴性菌、革兰氏阳性菌和酵母Candida albicans 具有抗性。

化合物

Cat.No: T63166

Synonym: LSN-3318839,LSN 3318839

Target: Glucagon Receptor

(S, R)-LSN 3318839

Cat.No: T63166L

Synonym: (S, R)-LSN 3318839(Isomer-2764704-18-7)

Target: Glucagon Receptor

Cat.No: T27854

Synonym: LSN-2463359,LSN 2463359

Target: GluR

Cat.No: T11884

Target: Others

Cat.No: T27855

Synonym: LSN-2814617,LSN 2814617

Leustroducsin B

Cat.No: T32687

Synonym: LSN B

LSN3106729 hydrochloride

Cat.No: T36967

Leustroducsin A

Cat.No: T32686

Synonym: LSN A

Cat.No: T4376

Synonym: LSN3154567

Target: c-Fms, NAMPT, CSF-1R

LSN3172176 Precursor

Cat.No: T32904

Synonym: LSN-3172176 Precursor,LSN 3172176 Precursor

Leustroducsin C

Cat.No: T32688

Synonym: LSN C

Cat.No: T10220

Synonym: Abemaciclib metabolite M2

Target: CDK

Abemaciclib metabolite M20

Cat.No: T10738

Synonym: CDK4/6-IN-4,LSN3106726

Target: CDK

Cat.No: T75112

GVLSNVIGYLKKLGTGALNAVLKQ

Cat.No: T76470

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00827	CD43 Protein, Mouse, Recombinant (His) SPN,GPL115,Galgp,Ly-48,CD43,Leukosialin,Sialophorin,A630014B...	Mouse	HEK293 Cells
	CD43 is a large transmembrane protein involved in T cell activation. Previous studies of CD43-/- mice in viral models have demonstrated a role for CD43 in Th1/Th2 skewing, activation of Foxp3 Treg, and T cell apoptosis. CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions...
TMPK-01305	CD43 Protein, Cynomolgus, Recombinant (His) CD43,A630014B01Rik,LSN,GPL115,Galgp,SPN,Ly-48,Leuko...	Cynomolgus	HEK293 Cells
	CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. The induction of acute myocarditis involves the engagement of CD43 cytoplasmic tripeptide sequence KRR to ezrin-radixin-moiesin cytoskeletal proteins. CD43 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 ...
TMPK-00832	CD43 Protein, Human, Recombinant (His) Galgp,SPN,LSN,Sialophorin,CD43,A630014B01Rik,GPL115...	Human	HEK293 Cells
	CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. The induction of acute myocarditis involves the engagement of CD43 cytoplasmic tripeptide sequence KRR to ezrin-radixin-moiesin cytoskeletal proteins. CD43 Protein, Human, Recombinant (His) is expressed in HEK293 mamma...

重组蛋白

CD43 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00827

Species: Mouse

Expression System: HEK293 Cells

CD43 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01305

Species: Cynomolgus

Expression System: HEK293 Cells

CD43 Protein, Human, Recombinant (His)

Cat.No: TMPK-00832

Species: Human

Expression System: HEK293 Cells

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