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Search Results for " l1210 "

14

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1488	Procarbazine hydrochloride NSC-77213 HCl,盐酸甲基苄肼,Procarbazine HCl	DNA Alkylator/Crosslinker; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Procarbazine hydrochloride (NSC-77213 HCl) 是一种烷化剂，是甲基肼衍生物的盐酸盐，具有抗肿瘤和诱变活性。
T6632	Raltitrexed ZD1694,雷替曲塞,D1694,ICI-D1694,Tomudex	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Raltitrexed (D1694) 是一种抗代谢药物，通过抑制胸苷酸合成酶起作用，可用于化疗。
T1349	5-Fluorouridine	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	5-Fluorouridine 是一种 5-fluorouracil 的代谢物，具有抗癌作用。它对 L1210 细胞的生长具有细胞毒性作用，其作用的 IC50值为 2 nM。它能抑制人结肠癌细胞 rRNA 的合成。
T24990	8-Deazafolic acid NSC-173522,NSC173522,NSC 173522
	8-Deazafolic acid is a potent folate-dependent bacteria inhibitor, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 7469), and to have activity against lymphoid leukemia L1210 in mice.
T69057	Elliptinium acetate NSC 264137,Celiptium,NSC 264137 ; Celiptium
	Elliptinium acetate (NSC 264137)为DNA插层剂，对L1210细胞显示出明显细胞毒性，并能与其核酸进行共价结合。该化合物主要用于癌症研究，特别是转移性乳腺癌。
T68952	NU1064
	NU1064 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which can potentiate the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. NU1064 potentiated a sublethal concentration of a DNA methylating agent in a concentration-dependent manner.
T69172	Acetomycin
	Acetomycin is a γ-lactone microbial metabolite originally isolated from S. ramulosus that has anticancer activity. It inhibits proliferation of HCT-8 human colon and L1210 mouse leukemia cancer cells.
T69199	Homopteroic Acid
	Homopteroic Acid is an intermediate in the synthesis of Homofolic Acid which inhibits the growth of L1210 mouse leukemia cells when intracellular folates are acquired via the high-affinity folate binding protein.
T36748	Heliquinomycin
	Heliquinomycin is a bacterial metabolite originally isolated fromStreptomycesthat has diverse biological activities.1It is active against a variety of Gram-positive bacteria, including strains ofB. anthracis, B. subtilis, and methicillin-sensitive or -resistantS. aureus(MICs = <0.05-0.39 μg/ml). Heliquinomycin inhibits the activity of DNA helicase with a Kivalue of 6.8 μM. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC50s = 0.97, 0.89, and 0.83 μg/ml, resp...
T38101	Bisucaberin
	Bisucaberin is a siderophore and bacterial metabolite that has been found inA. haloplanktisand has anticancer activity.1,2It inhibits the growth of L1210 and 1MC carcinoma cells (IC50s = 9.7 and 12.7 μM, respectively) and sensitizes fibrosarcoma 1023 cells to macrophage-mediated cytolysis. 1.Hou, Z., Raymond, K.N., O’Sullivan, B., et al.A preorganized siderophore: Thermodynamic and structural characterization of alcaligin and bisucaberin, microbial macrocyclic dihydroxamate chelating agentsInorg...
T38383	Altemicidin
	Altemicidin is a monoterpene alkaloid originally isolated fromS. sioyaensiswith acaricidal and anticancer activities.1It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s = 0.84 and 0.82 μg/ml, respectively). It is toxic to mice with an LD50value of 0.3 mg/kg. 1.Takahashi, A., Kurasawa, S., Ikeda, D., et al.Altemicidin, a new acari...
T36477	Urdamycin A
	Urdamycin A is a bacterial metabolite originally isolated fromS. fradiaethat has antibacterial and anticancer activities.1,2It is active against a variety of Gram-positive and Gram-negative bacteria, includingB. subtilisand strains ofArthrobacterandStreptomyces, but not the fungusS. cerevisiae, in a disc assay when used at a concentration of 1 mg/ml.2Urdamycin A is cytotoxic to L1210 and HT-29, but not A549, cancer cells (IC50s = 7.5, 5, and >10 μg/ml, respectively).1
T70304	CI-898 HCl
	CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.
T68667	Oxanosine
	Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively). It al...

化合物

Procarbazine hydrochloride

Cat.No: T1488

Synonym: NSC-77213 HCl,盐酸甲基苄肼,Procarbazine HCl

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Cat.No: T6632

Synonym: ZD1694,雷替曲塞,D1694,ICI-D1694,Tomudex

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

5-Fluorouridine

Cat.No: T1349

Target: Others, DNA/RNA Synthesis

8-Deazafolic acid

Cat.No: T24990

Synonym: NSC-173522,NSC173522,NSC 173522

Elliptinium acetate

Cat.No: T69057

Synonym: NSC 264137,Celiptium,NSC 264137 ; Celiptium

Cat.No: T68952

Cat.No: T69172

Homopteroic Acid

Cat.No: T69199

Cat.No: T36748

Cat.No: T38101

Cat.No: T38383

Cat.No: T36477

Cat.No: T70304

Cat.No: T68667

Cat. No.	Product Name	Target	Signaling Pathways
TQ0213	Bruceantin 鸦胆亭,(-)-Bruceantin,NCI165563,鸦胆停,NSC165563	Others	Others
	Bruceantin (NSC-165563) 提取自痢鸦胆子中，显示出对 B16黑色素瘤，结肠癌38，L1210和白血病 P388的抑制活性。
T4745	4-Carboxyquinoline QUINOLINE-4-CARBOXYLIC ACID,喹啉-4-羧酸,4-Quinolinecarboxylic acid	Others; Endogenous Metabolite	Metabolism; Others
	4-Carboxyquinoline (4-Quinolinecarboxylic acid) 是内源性代谢产物的一种。
T8188	Podophyllotoxone	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	Podophyllotoxone 是从八角莲根中分离得到的一种天然产物，能抑制微管蛋白聚合，具有抗癌活性。
TN2496	1,4-Anthraquinone	Others	Others
	1,4-Anthraquinone 是一种抗癌药物，在体外与柔红霉素相同纳摩尔范围内阻断核苷转运、抑制大分子合成、诱导 DNA 片段化并降低 L1210 白血病细胞的生长和活力。它被提议为一种用于高效液相色谱 (HPLC) 测定药物制剂中 N-乙酰半胱氨酸 (NAC) 和卡托普利 (CAP) 的新型柱前试剂。
T3S1955	7-Ethylcamptothecin	Others	Others
	7-Ethylcamptothecin 是一种喜树碱类似物。其中喜树碱是一种细胞毒性生物碱，从喜树中分离出得到，对 L1210 白血病和 Walker 256 癌肉瘤模型具有很强的抗肿瘤活性。
TN3075	5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone	ATPase	Membrane transporter/Ion channel
	5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone (ED 50 =4.5 ug/ml ) shows cytotoxicity against L1210 cell and has inhibiting effects on ATPase from the cell.
TN6069	Thalidezine
	Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death, it can inhibit the growth of mouse L1210 cells in vitro. Thalidezine possesses antimicrobial activity against Mycobacterium sme
TN4944	Santamarine	Caspase	Apoptosis; Proteases/Proteasome
	Santamarine has significant anticancer activity, can inhibit L1210 cells because of its cytotoxic,cytostatic and blocking mitosis and reducing uptake of thymidine. Santamarine and reynosin show bactericidal activity against clinical strains of Mycobacterium tuberculosis.
TMA2418	1-Methoxyphaseollidin	PAFR; Antifection	GPCR/G Protein; Microbiology/Virology
	1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Methoxyphaseollidin may show moderate cytotoxic activity against KB and L1210 cells. 1-Methoxyphaseollidin also shows inhibition of lysoPAF acetyltransferase activity.
T75453	11-epi-Chaetomugilin I
	11-epi-Chaetomugilin I 是一种在Chaetomium globosum 中发现的代谢物。11-epi-Chaetomugilin I 对小鼠 P388 白血病细胞系、人类 HL-60 白血病细胞系、小鼠 L1210 白血病细胞系和人类 KB 表皮样癌细胞系具有显著的细胞毒性活性。
T83862	Bactobolin A hydrochloride BN-183B
	Bactobolin A 是一种最初从 Pseudomonas 中分离出的微生物代谢产物，具有抗生素和抗癌活性。它对 S. aureus、S. epidermidis、S. faecalis、B. anthracis、B. subtilis、E. coli、S. typhi 和 S. dysenteriae 活跃(MICs = 0.1-12.5 µg/ml)。在体内，bactobolin A (0.25-4 mg/kg) 提高了 L1210 小鼠白血病模型的存活率。

天然产物

Cat.No: TQ0213

Synonym: 鸦胆亭,(-)-Bruceantin,NCI165563,鸦胆停,NSC165563

Target: Others

4-Carboxyquinoline

Cat.No: T4745

Synonym: QUINOLINE-4-CARBOXYLIC ACID,喹啉-4-羧酸,4-Quinolinecarboxylic acid

Target: Others, Endogenous Metabolite

Podophyllotoxone

Cat.No: T8188

Target: Others, Microtubule Associated

1,4-Anthraquinone

Cat.No: TN2496

Target: Others

7-Ethylcamptothecin

Cat.No: T3S1955

Target: Others

5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone

Cat.No: TN3075

Target: ATPase

Cat.No: TN6069

Cat.No: TN4944

Target: Caspase

1-Methoxyphaseollidin

Cat.No: TMA2418

Target: PAFR, Antifection

11-epi-Chaetomugilin I

Cat.No: T75453

Bactobolin A hydrochloride

Cat.No: T83862

Synonym: BN-183B

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