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14
Cat. No. | Product Name | Target | Signaling Pathways |
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T24408 |
L-Glucose-1-14C
L-(1-14C)Glucose |
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L-Glucose-1-14C is the L-isomer of glucose. It also is the enantiomer of the more common D-glucose. | |||
T15244 |
Ertugliflozin L-pyroglutamic acid
埃格列净,PF-04971729 L-pyroglutamic acid |
Others; SGLT | GPCR/G Protein; Others |
Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) 是一种特异性和口服活性的 hSGLT2 抑制剂,IC50 为 0.877 nM。 Ertugliflozin L-pyroglutamic acid 可用于治疗 2 型糖尿病的研究。 | |||
T1137 |
Clorsulon
克洛索隆,L631529,MK401,氯舒隆 |
ATPase; Antibiotic; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
Clorsulon (L631529) 是一种具有口服活性的灭虫试剂,用于犊牛和羊的肝吸虫 感染。它也是 3-磷酸甘酸酯和 ATP 的竞争性抑制剂,可抑制成熟肝片吸虫对葡萄糖的利用以及乙酸和丙酸的形成。 | |||
T24392 |
L-Chlorozotocin
NSC-291322,NSC291322,NSC 291322 |
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L-Chlorozotocin is a glucose-linked chloroethyl nitrosourea with potential antineoplastic activity. | |||
T24365 |
L 858051
7B-Forskolin,L858051,Dmpb-forskolin,L-858051 |
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L 858051 activates adenylate cyclase. It also inhibits glucose transport in rat adipocytes. | |||
T38489 | D,L-erythro-PDMP | ||
D,L-erythro-PDMP, an erythro isomer of PDMP, exhibits growth inhibition on cultured rabbit skin fibroblasts. Additionally, this compound serves as an effective inhibitor of UDP-glucose: ceramide glucosyltransferase. | |||
T80441 |
FS-2
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
FS-2,一种特异性L型CaV通道抑制剂,能够阻断RIN beta 细胞中,高K+或葡萄糖刺激导致的L型Ca2+内流。 | |||
T72460 |
Dimethyl L-glutamate
Dimethyl glutamate |
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Dimethyl L-glutamate (Dimethyl glutamate), 一种可透膜的谷氨酸类似物,可刺激葡萄糖诱导的胰岛素 (insulin) 释放。Dimethyl L-glutamate 抑制KATP 通道的活性。Dimethyl L-glutamate 抑制E. gracilis 生长并导致细胞异常分裂。Dimethyl L-glutamate 可用于糖尿病、葡萄糖转运、磷酸化和进一步代谢的研究。 | |||
T81935 |
L-Glutamic γ-monohydroxamate
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L-Glutamic γ-monohydroxamate是一种特异性抗肿瘤试剂,能够抑制癌细胞的增殖,并针对性地阻止微血管内皮细胞摄取L-组氨酸。作为钒配体,该化合物还能激活脂肪细胞对葡萄糖的摄取和代谢,进而有效降低血糖水平。 | |||
T37477 |
L-858,051 (hydrochloride)
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L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes. L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture. | |||
T71809 |
L-Xylulose
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L-Xylulose is an intermediate in certain metabolic pathways and is classified as a rare sugar. It shows important physiological effects such as acting as an inhibitor of α-glucosidase and decreasing blood glucose, and it can be employed to produce other significant rare sugars, such as L-ribose and L-xylose which contribute to the production of antiviral drugs. | |||
T20256 |
Sorbitol, L-
L-Glucitol |
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Sorbitol, L- is a sugar alcohol. It can be obtained by the reduction of glucose, which changes the aldehyde group to a hydroxyl group. It is converted to fructose by sorbitol-6-phosphate 2-dehydrogenase. Sorbitol is an isomer of mannitol, another sugar al | |||
T61715 | RmlA-IN-1 | ||
RmlA-IN-1 (Compound 8a) is a highly potent inhibitor of glucose-1-phosphate thymidylyltransferase (RmlA), with an IC50 value of 0.073 μM. It significantly modulates the biosynthesis of monosaccharide l-Rhamnose and impacts the permeability of the bacterial cell wall [1]. | |||
T26868 |
BMS-986118
BMS 986118 |
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BMS-986118 is a full agonist of GPR40, is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial a | |||
T3984 |
GLP-1(7-36), amide
MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide |
Glucagon Receptor | GPCR/G Protein |
GLP-1(7-36), amide (MKC 253) 是一种生理性肠降血糖素,能够刺激胰岛素分泌。 | |||
T78066 |
BBT
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Calcium Channel | Membrane transporter/Ion channel; Metabolism |
BBT是一种增强剂,用于改善受损的葡萄糖刺激胰岛素分泌(GSIS)。该化合物展现出抗高血糖的活性,并能在2型糖尿病模型中,对β细胞起到保护作用,抵御细胞因子或链脲佐菌素(STZ)引起的细胞死亡。BBT的作用机制涉及通过cAMP/PKA及持久(L型)电压依赖性Ca2+通道/CaMK2通路。 | |||
T36057 |
Diallyl Tetrasulfide
ICD-1585 |
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Diallyl tetrasulfide is an organosulfur compound that has been found in A. sativum and has diverse biological activities, including antimicrobial, antioxidant, and anticancer properties.[1],[2],[3],[4] It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MICs = 0.5 and 2 mg/L, respectively), as well as the fungi C. albicans, C. krusei, C. glabrata, A. niger, A. flavus, and A. fumigatus (MICs = 0.5, 4, 2, 1, 2, and 4 mg/L, respectively).[1] It reduces cadmium-ind... | |||
T35816 |
ZLY032
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ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic st... | |||
T83721 |
Hexafluoropropylene Oxide Dimer Acid
FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA |
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Hexafluoropropylene oxide dimer acid (HFPO-DA)作为一种全氟烷基醚羧酸(PFECA),于HepG2细胞中以250 µM的浓度使用时,可诱导凋亡并增加活性氧种类(ROS)的水平。HFPO-DA以每个蛋4 mg/kg的剂量,会减少孵化鸡右心室壁厚度,增加心率,并诱导肝脏脂肪积累,这些效应可通过敲除过氧化物酶体增殖物激活受体α(Ppara)基因编码实现预防。它减少了斑马鱼胚胎的存活百分比(LC50 = 7,651 mg/L)。在孕妇大鼠给药下,HFPO-DA(250 mg/kg)降低了新生大鼠的平均出生体重、存活时间和血清葡萄糖水平,并增加了血清胆固醇和甘油三酯水平。它已经被发现污染海水和河水。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T5113 |
L-GLUCOSE
L-葡萄糖,L-(-)-Glucose |
Others | Others |
L-Glucose (L-(-)-Glucose) 是一种 D-glucose 的对映体,可促进食物的摄取。 | |||
T81992 |
Kaempferol 3,7-bis(α-L-rhamnose-D-glucose)
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Kaempferol 3,7-bis(α-L-rhamnose-D-glucose) (化合物1)为Euonymus fortune中存在的黄酮苷。 | |||
T20255 |
L-Galactose
Galactose, L- |
Endogenous Metabolite | Metabolism |
L-Galactose (Galactose, L-) 是一种天然产物,广泛存在动植物体内。L-Galactose 在Pistia stratiotes 中被证明是D-葡萄糖转化为草酸的分子途径中的关键中间体。 | |||
T4929 |
L-2-Phosphoglyceric acid
L-GLYCERATE 3-PHOSPHATE 二钠盐,L-2-Phosphoglyceric acid disodium salt h |
Others; Endogenous Metabolite | Metabolism; Others |
L-2-Phosphoglyceric acid (L-2-Phosphoglyceric acid disodium salt) 是内源性代谢产物的一种。 | |||
T4785 |
Oxfenicine
4-羟基-L-苯甘氨酸,4-Hydroxy-L-phenylglycine |
Others | Others |
Oxfenicine (4-Hydroxy-L-phenylglycine) 是具有口服活性的肉碱棕榈酰转移酶-1 抑制剂。它在缺血期间保护心脏免受坏死组织的损害。它可抑制心脏中脂肪酸的氧化。 | |||
T13979 |
(S)-3-Hydroxybutanoic acid
L-β-Hydroxybutyric acid,(S)-β-Hydroxybutanoic acid,L-(+)-3-Hydroxybutyric acid,(S)-3-羟基丁酸 |
Endogenous Metabolite | Metabolism |
(S)-3-Hydroxybutanoic acid (L-(+)-3-Hydroxybutyric acid) 是一种正常的人体代谢产物,在患有抑郁症的老年患者中升高。它在人类的肝脏中由乙酰-CoA 合成,当血糖低时能够被脑用作能量来源。 | |||
T13752 |
L-(+)-Arabinose
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Endogenous Metabolite | Metabolism |
L-(+)-Arabinose 能够选择性抑制肠道蔗糖酶,并抑制因蔗糖摄入而导致的血浆葡萄糖提高。 | |||
TN1003 |
DL-Alanine
DL-2-Aminopropionic acid |
Endogenous Metabolite | Metabolism |
DL-Alanine (DL-2-Aminopropionic acid) 是一种氨基酸,是L-和D-丙氨酸的外消旋化合物。DL-Alanine 与硝酸银水溶液一起用于纳米颗粒生成时常作为还原剂和封端剂。DL-Alanine 是一种甜味剂,可把它位与甘氨酸和糖精钠归为一类。DL-Alanine 在组织和肝脏之间的葡萄糖-丙氨酸循环中起重要作用。DL-Alanine 可用于研究 Cu、Zn、Cd 等过渡金属螯合。 | |||
TN2473 |
1-(4-Hydroxybenzoyl)glucose
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Others | Others |
1-(4-Hydroxybenzoyl)glucose is a natural product from Luffa cylindrica (L.) Roem. | |||
T8479 |
1-O-Galloyl-2-O-cinnamoyl-glucose
2-O-cinnamoyl-1-O-galloyl-β-D-glucose,2-O-肉桂酰基-1-O-没食子酰基-Β-D-葡萄糖苷 |
Others | Others |
1-O-Galloyl-2-O-cinnamoyl-glucose 是一种存在于 R. palmatum L.中的天然产物。 | |||
T78481 |
Lactodifucotetraose
2′,3-Difucosyllactose,Difucosyllactose |
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Lactodifucotetraose (Difucosyllactose),一种四糖,源自人乳。该分子包括D-葡萄糖,D-半乳糖及L-fucose。 | |||
T81222 |
Salvifaricin
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Salvifaricin是一种口服活性的二萜类化合物,可从墨西哥鼠尾草和西班牙鼠尾草中提取。Salvifaricin能显著降低空腹血糖以及血清甘油三酯(TG)水平,表现出抗糖尿病的效果。 | |||
TN6515 |
Selaginellin
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Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene. Selaginellin shows | |||
T5141 |
L-2-Phosphoglyceric acid disodium salt hydrate
L-2-Phosphoglyceric acid 二钠盐水合物 |
Others | Others |
L-2-Phosphoglyceric acid disodium salt hydrate 是一种甘油酸,可作为糖酵解第九步的底物。它被烯醇化酶催化为磷酸烯醇式丙酮酸 (PEP),这是葡萄糖转化为丙酮酸的倒数第二个步骤。 |