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19

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T24408	L-Glucose-1-14C L-(1-14C)Glucose
	L-Glucose-1-14C is the L-isomer of glucose. It also is the enantiomer of the more common D-glucose.
T15244	Ertugliflozin L-pyroglutamic acid 埃格列净,PF-04971729 L-pyroglutamic acid	Others; SGLT	GPCR/G Protein; Others
	Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) 是一种特异性和口服活性的 hSGLT2 抑制剂，IC50 为 0.877 nM。 Ertugliflozin L-pyroglutamic acid 可用于治疗 2 型糖尿病的研究。
T1137	Clorsulon 克洛索隆,L631529,MK401,氯舒隆	ATPase; Antibiotic; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	Clorsulon (L631529) 是一种具有口服活性的灭虫试剂，用于犊牛和羊的肝吸虫感染。它也是 3-磷酸甘酸酯和 ATP 的竞争性抑制剂，可抑制成熟肝片吸虫对葡萄糖的利用以及乙酸和丙酸的形成。
T24392	L-Chlorozotocin NSC-291322,NSC291322,NSC 291322
	L-Chlorozotocin is a glucose-linked chloroethyl nitrosourea with potential antineoplastic activity.
T24365	L 858051 7B-Forskolin,L858051,Dmpb-forskolin,L-858051
	L 858051 activates adenylate cyclase. It also inhibits glucose transport in rat adipocytes.
T38489	D,L-erythro-PDMP
	D,L-erythro-PDMP, an erythro isomer of PDMP, exhibits growth inhibition on cultured rabbit skin fibroblasts. Additionally, this compound serves as an effective inhibitor of UDP-glucose: ceramide glucosyltransferase.
T80441	FS-2	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	FS-2，一种特异性L型CaV通道抑制剂，能够阻断RIN beta 细胞中，高K+或葡萄糖刺激导致的L型Ca2+内流。
T72460	Dimethyl L-glutamate Dimethyl glutamate
	Dimethyl L-glutamate (Dimethyl glutamate), 一种可透膜的谷氨酸类似物，可刺激葡萄糖诱导的胰岛素 (insulin) 释放。Dimethyl L-glutamate 抑制KATP 通道的活性。Dimethyl L-glutamate 抑制E. gracilis 生长并导致细胞异常分裂。Dimethyl L-glutamate 可用于糖尿病、葡萄糖转运、磷酸化和进一步代谢的研究。
T81935	L-Glutamic γ-monohydroxamate
	L-Glutamic γ-monohydroxamate是一种特异性抗肿瘤试剂，能够抑制癌细胞的增殖，并针对性地阻止微血管内皮细胞摄取L-组氨酸。作为钒配体，该化合物还能激活脂肪细胞对葡萄糖的摄取和代谢，进而有效降低血糖水平。
T37477	L-858,051 (hydrochloride)
	L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes. L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.
T71809	L-Xylulose
	L-Xylulose is an intermediate in certain metabolic pathways and is classified as a rare sugar. It shows important physiological effects such as acting as an inhibitor of α-glucosidase and decreasing blood glucose, and it can be employed to produce other significant rare sugars, such as L-ribose and L-xylose which contribute to the production of antiviral drugs.
T20256	Sorbitol, L- L-Glucitol
	Sorbitol, L- is a sugar alcohol. It can be obtained by the reduction of glucose, which changes the aldehyde group to a hydroxyl group. It is converted to fructose by sorbitol-6-phosphate 2-dehydrogenase. Sorbitol is an isomer of mannitol, another sugar al
T61715	RmlA-IN-1
	RmlA-IN-1 (Compound 8a) is a highly potent inhibitor of glucose-1-phosphate thymidylyltransferase (RmlA), with an IC50 value of 0.073 μM. It significantly modulates the biosynthesis of monosaccharide l-Rhamnose and impacts the permeability of the bacterial cell wall [1].
T26868	BMS-986118 BMS 986118
	BMS-986118 is a full agonist of GPR40, is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial a
T3984	GLP-1(7-36), amide MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide	Glucagon Receptor	GPCR/G Protein
	GLP-1(7-36), amide (MKC 253) 是一种生理性肠降血糖素，能够刺激胰岛素分泌。
T78066	BBT	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	BBT是一种增强剂，用于改善受损的葡萄糖刺激胰岛素分泌(GSIS)。该化合物展现出抗高血糖的活性，并能在2型糖尿病模型中，对β细胞起到保护作用，抵御细胞因子或链脲佐菌素(STZ)引起的细胞死亡。BBT的作用机制涉及通过cAMP/PKA及持久（L型）电压依赖性Ca2+通道/CaMK2通路。
T36057	Diallyl Tetrasulfide ICD-1585
	Diallyl tetrasulfide is an organosulfur compound that has been found in A. sativum and has diverse biological activities, including antimicrobial, antioxidant, and anticancer properties.[1],[2],[3],[4] It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MICs = 0.5 and 2 mg/L, respectively), as well as the fungi C. albicans, C. krusei, C. glabrata, A. niger, A. flavus, and A. fumigatus (MICs = 0.5, 4, 2, 1, 2, and 4 mg/L, respectively).[1] It reduces cadmium-ind...
T35816	ZLY032
	ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic st...
T83721	Hexafluoropropylene Oxide Dimer Acid FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA
	Hexafluoropropylene oxide dimer acid (HFPO-DA)作为一种全氟烷基醚羧酸(PFECA)，于HepG2细胞中以250 µM的浓度使用时，可诱导凋亡并增加活性氧种类(ROS)的水平。HFPO-DA以每个蛋4 mg/kg的剂量，会减少孵化鸡右心室壁厚度，增加心率，并诱导肝脏脂肪积累，这些效应可通过敲除过氧化物酶体增殖物激活受体α(Ppara)基因编码实现预防。它减少了斑马鱼胚胎的存活百分比(LC50 = 7,651 mg/L)。在孕妇大鼠给药下，HFPO-DA（250 mg/kg）降低了新生大鼠的平均出生体重、存活时间和血清葡萄糖水平，并增加了血清胆固醇和甘油三酯水平。它已经被发现污染海水和河水。

化合物

L-Glucose-1-14C

Cat.No: T24408

Synonym: L-(1-14C)Glucose

Ertugliflozin L-pyroglutamic acid

Cat.No: T15244

Synonym: 埃格列净,PF-04971729 L-pyroglutamic acid

Target: Others, SGLT

Cat.No: T1137

Synonym: 克洛索隆,L631529,MK401,氯舒隆

Target: ATPase, Antibiotic, Parasite

L-Chlorozotocin

Cat.No: T24392

Synonym: NSC-291322,NSC291322,NSC 291322

Cat.No: T24365

Synonym: 7B-Forskolin,L858051,Dmpb-forskolin,L-858051

D,L-erythro-PDMP

Cat.No: T38489

Cat.No: T80441

Target: Calcium Channel

Dimethyl L-glutamate

Cat.No: T72460

Synonym: Dimethyl glutamate

L-Glutamic γ-monohydroxamate

Cat.No: T81935

L-858,051 (hydrochloride)

Cat.No: T37477

Cat.No: T71809

Cat.No: T20256

Synonym: L-Glucitol

Cat.No: T61715

Cat.No: T26868

Synonym: BMS 986118

GLP-1(7-36), amide

Cat.No: T3984

Synonym: MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide

Target: Glucagon Receptor

Cat.No: T78066

Target: Calcium Channel

Diallyl Tetrasulfide

Cat.No: T36057

Synonym: ICD-1585

Cat.No: T35816

Hexafluoropropylene Oxide Dimer Acid

Cat.No: T83721

Synonym: FRD-903,Perfluoro-2-propoxypropanoic Acid,PFPrOPrA,HFPO-DA

Cat. No.	Product Name	Target	Signaling Pathways
T5113	L-GLUCOSE L-葡萄糖,L-(-)-Glucose	Others	Others
	L-Glucose (L-(-)-Glucose) 是一种 D-glucose 的对映体，可促进食物的摄取。
T81992	Kaempferol 3,7-bis(α-L-rhamnose-D-glucose)
	Kaempferol 3,7-bis(α-L-rhamnose-D-glucose) (化合物1)为Euonymus fortune中存在的黄酮苷。
T20255	L-Galactose Galactose, L-	Endogenous Metabolite	Metabolism
	L-Galactose (Galactose, L-) 是一种天然产物，广泛存在动植物体内。L-Galactose 在Pistia stratiotes 中被证明是D-葡萄糖转化为草酸的分子途径中的关键中间体。
T4929	L-2-Phosphoglyceric acid L-GLYCERATE 3-PHOSPHATE 二钠盐,L-2-Phosphoglyceric acid disodium salt h	Others; Endogenous Metabolite	Metabolism; Others
	L-2-Phosphoglyceric acid (L-2-Phosphoglyceric acid disodium salt) 是内源性代谢产物的一种。
T4785	Oxfenicine 4-羟基-L-苯甘氨酸,4-Hydroxy-L-phenylglycine	Others	Others
	Oxfenicine (4-Hydroxy-L-phenylglycine) 是具有口服活性的肉碱棕榈酰转移酶-1 抑制剂。它在缺血期间保护心脏免受坏死组织的损害。它可抑制心脏中脂肪酸的氧化。
T13979	(S)-3-Hydroxybutanoic acid L-β-Hydroxybutyric acid,(S)-β-Hydroxybutanoic acid,L-(+)-3-Hydroxybutyric acid,(S)-3-羟基丁酸	Endogenous Metabolite	Metabolism
	(S)-3-Hydroxybutanoic acid (L-(+)-3-Hydroxybutyric acid) 是一种正常的人体代谢产物，在患有抑郁症的老年患者中升高。它在人类的肝脏中由乙酰-CoA 合成，当血糖低时能够被脑用作能量来源。
T13752	L-(+)-Arabinose	Endogenous Metabolite	Metabolism
	L-(+)-Arabinose 能够选择性抑制肠道蔗糖酶，并抑制因蔗糖摄入而导致的血浆葡萄糖提高。
TN1003	DL-Alanine DL-2-Aminopropionic acid	Endogenous Metabolite	Metabolism
	DL-Alanine (DL-2-Aminopropionic acid) 是一种氨基酸，是L-和D-丙氨酸的外消旋化合物。DL-Alanine 与硝酸银水溶液一起用于纳米颗粒生成时常作为还原剂和封端剂。DL-Alanine 是一种甜味剂，可把它位与甘氨酸和糖精钠归为一类。DL-Alanine 在组织和肝脏之间的葡萄糖-丙氨酸循环中起重要作用。DL-Alanine 可用于研究 Cu、Zn、Cd 等过渡金属螯合。
TN2473	1-(4-Hydroxybenzoyl)glucose	Others	Others
	1-(4-Hydroxybenzoyl)glucose is a natural product from Luffa cylindrica (L.) Roem.
T8479	1-O-Galloyl-2-O-cinnamoyl-glucose 2-O-cinnamoyl-1-O-galloyl-β-D-glucose,2-O-肉桂酰基-1-O-没食子酰基-Β-D-葡萄糖苷	Others	Others
	1-O-Galloyl-2-O-cinnamoyl-glucose 是一种存在于 R. palmatum L.中的天然产物。
T78481	Lactodifucotetraose 2′,3-Difucosyllactose,Difucosyllactose
	Lactodifucotetraose (Difucosyllactose)，一种四糖，源自人乳。该分子包括D-葡萄糖，D-半乳糖及L-fucose。
T81222	Salvifaricin
	Salvifaricin是一种口服活性的二萜类化合物，可从墨西哥鼠尾草和西班牙鼠尾草中提取。Salvifaricin能显著降低空腹血糖以及血清甘油三酯(TG)水平，表现出抗糖尿病的效果。
TN6515	Selaginellin
	Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene. Selaginellin shows
T5141	L-2-Phosphoglyceric acid disodium salt hydrate L-2-Phosphoglyceric acid 二钠盐水合物	Others	Others
	L-2-Phosphoglyceric acid disodium salt hydrate 是一种甘油酸，可作为糖酵解第九步的底物。它被烯醇化酶催化为磷酸烯醇式丙酮酸 (PEP)，这是葡萄糖转化为丙酮酸的倒数第二个步骤。

天然产物

Cat.No: T5113

Synonym: L-葡萄糖,L-(-)-Glucose

Target: Others

Kaempferol 3,7-bis(α-L-rhamnose-D-glucose)

Cat.No: T81992

Cat.No: T20255

Synonym: Galactose, L-

Target: Endogenous Metabolite

L-2-Phosphoglyceric acid

Cat.No: T4929

Synonym: L-GLYCERATE 3-PHOSPHATE 二钠盐,L-2-Phosphoglyceric acid disodium salt h

Target: Others, Endogenous Metabolite

Cat.No: T4785

Synonym: 4-羟基-L-苯甘氨酸,4-Hydroxy-L-phenylglycine

Target: Others

(S)-3-Hydroxybutanoic acid

Cat.No: T13979

Synonym: L-β-Hydroxybutyric acid,(S)-β-Hydroxybutanoic acid,L-(+)-3-Hydroxybutyric acid,(S)-3-羟基丁酸

Target: Endogenous Metabolite

L-(+)-Arabinose

Cat.No: T13752

Target: Endogenous Metabolite

Cat.No: TN1003

Synonym: DL-2-Aminopropionic acid

Target: Endogenous Metabolite

1-(4-Hydroxybenzoyl)glucose

Cat.No: TN2473

Target: Others

1-O-Galloyl-2-O-cinnamoyl-glucose

Cat.No: T8479

Synonym: 2-O-cinnamoyl-1-O-galloyl-β-D-glucose,2-O-肉桂酰基-1-O-没食子酰基-Β-D-葡萄糖苷

Target: Others

Lactodifucotetraose

Cat.No: T78481

Synonym: 2′,3-Difucosyllactose,Difucosyllactose

Cat.No: T81222

Cat.No: TN6515

L-2-Phosphoglyceric acid disodium salt hydrate

Cat.No: T5141

Synonym: L-2-Phosphoglyceric acid 二钠盐水合物

Target: Others

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