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Cat. No. Product Name Target Signaling Pathways
T24239 K201

K-201,JTV 519,JTV-519,K 201

Calcium Channel Membrane transporter/Ion channel; Metabolism
K201 (JTV-519) 是一种 Ca2+ 依赖性阻滞剂,通过稳定兰尼碱受体来防止缺血性心脏和骨骼肌 (SkM) 中的肌质网异常 Ca(2+) 泄漏。
T11732 JTV-519 hemifumarate

K201 hemifumarate

MELK PI3K/Akt/mTOR signaling
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle.
T11731 JTV-519 free base

K201 free base

FLT Angiogenesis; Tyrosine Kinase/Adaptors
JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and serves as a partial agonist of ryanodine receptors in striated muscle.
T7360 GSK2018682

S1P Receptor; LPL Receptor GPCR/G Protein
GSK2018682 是 1-磷酸鞘氨醇受体S1P1和S1P5激动剂,pEC50值分别为 7.7 和 7.2,可用于多发性硬化的研究。
T71564 GSK2018682 HCl

GSK2018682 is a novel sphingosine-1-phosphate receptor 1 (s1p1) and 5 (s1p5) agonist.
T37807 JTV 519 fumarate

Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID:17313373 |Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID:17994112 |...

化合物

K201
Cat.No: T24239
Synonym: K-201,JTV 519,JTV-519,K 201
Target: Calcium Channel
JTV-519 hemifumarate
Cat.No: T11732
Synonym: K201 hemifumarate
Target: MELK
JTV-519 free base
Cat.No: T11731
Synonym: K201 free base
Target: FLT
GSK2018682
Cat.No: T7360
Synonym:
Target: S1P Receptor, LPL Receptor
GSK2018682 HCl
Cat.No: T71564
Synonym:
Target:
JTV 519 fumarate
Cat.No: T37807
Synonym:
Target:
TargetMol Loading
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