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Cat. No.	Product Name	Target	Signaling Pathways
T1835	Ibrutinib 伊布替尼,依鲁替尼,PCI-32765	Tyrosine Kinases; Src; BTK; Ligands for Target Protein for PROTAC	Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors
	Ibrutinib (PCI-32765) 是一种不可逆的、选择性的 Btk 抑制剂，IC50=0.5 nM，它是一种 Btk 配体，用于合成一系列 PROTAC 分子，如 P13I。P13I 作用于人 Burkitt’s 淋巴瘤 RAMOS 细胞，浓度为 10 和 100 nM 时，分别降解 73% 和 89% Btk。
T9408	N-piperidine Ibrutinib	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	N-piperidine Ibrutinib 是一种有效的 BTK 抑制剂，对 WT BTK 和 C481S BTK 的 IC50 分别为 51.0 和 30.7 nM。它可作为BTK 配体用于一系列PROTAC 的合成，如SJF620。 SJF620 是一种有效的 PROTAC BTK 降解剂，DC50 为 7.9 nM。
T12152	N-piperidine Ibrutinib hydrochloride	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	N-piperidine Ibrutinib hydrochloride 是一种强效的 BTK 抑制剂，是BTK 配体，抑制 WT BTK 和 C481S BTK ，可用于合成一系列 PROTAC 分子。N-piperidine Ibrutinib hydrochloride具有潜在的抗癌活性，可抑制癌细胞的生长和增殖。
T8636	Ibrutinib deacryloylpiperidine IBT4A,5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine,伊布替尼中间体N-2	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Ibrutinib deacryloylpiperidine (IBT4A) 是 Ibrutinib 的杂质之一。它是一种不可逆的、选择性的 Btk 抑制剂 (IC50:0.5 nM)。
T11601	Ibrutinib-d5 PCI-32765 D5,Ibrutinib D5	Others	Others
	Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.
T11602	Ibrutinib dimer	Others	Others
	Ibrutinib dimer is an impurity of Ibrutinib. IIbrutinib dimer is a Dimer of Ibrutinib. Ibrutinib is an irreversible Btk inhibitor (IC50: 0.5 nM).
T36429	Dihydrodiol-Ibrutinib
	PCI 45227 is an active metabolite of the Bruton's tyrosine kinase inhibitor ibrutinib .1PCI 45227 is formed from ibrutinib by the cytochrome P450 (CYP) isoform CYP3A. 1.Veeraraghavan, S., Viswanadha, S., Thappali, S., et al.Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: Application to a pharmacokinetic studyJ. Pharm. Biomed. Anal.107151-158(2015)
T11603	Ibrutinib-MPEA	Others	Others
	Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible BTK inhibitor that has been used to treat hematological malignancies.
T18049	Ibrutinib-biotin	Others	Others
	Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, has an IC50 of 0.755-1.02 nM for BTK.
T16440	Ibrutinib Racemate PCI-32765 (Racemate)	Others	Others
	Ibrutinib is a selective, irreversible Btk inhibitor (IC50: 0.5 nM). Ibrutinib Racemate is the racemate of Ibrutinib.
T21357	Ibrutinib Interm 0441 (S)-1-Boc-3-hydroxypiperidine,(S)-1-Boc-3-piperidinol
	Ibrutinib Interm 0441 is a piperidine derivative with an amine protecting group and may be used in the preparation of biologically active compounds.
T16730	Remibrutinib	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Remibrutinib 是有效的、口服具有活力的 bruton tyrosine kinase 抑制剂 (IC50:1 nM)，在血液中抑制 BTK 活性的 IC50的值为 0.23 μM。它具有研究慢性荨麻疹的潜力。
T10626	(Rac)-IBT6A	Others; BTK	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	(Rac)-IBT6A 是 IBT6A 的外消旋体。 IBT6A 是依鲁替尼的杂质，可用于 IBT6A 依鲁替尼二聚体和 IBT6A 加合物的合成。
T10625	IBT6A 依鲁替尼中间体	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	IBT6A 是一种 Ibrutinib 的杂质。它可用于合成 IBT6A-Ibrutinib 二聚体和 IBT6A 加合物。Ibrutinib 是不可逆的选择性 Btk 抑制剂 (IC50:0.5 nM)。
T10625L2	IBT6A hydrochloride	Others	Others
	IBT6A hydrochloride is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.
T73942	(Rac)-IBT6A hydrochloride
	(Rac)-IBT6A hydrochloride 是 IBT6A hydrochloride 的消旋体。IBT6A 是 Ibrutinib 的一种杂质。IBT6A 可用于合成 IBT6A-Ibrutinib 二聚体和 IBT6A 加合物。Ibrutinib 是一种不可逆的选择性 Btk 抑制剂，IC50为 0.5 nM。
T10625L	(Rac)-IBT6A hydrochloride (1412418-47-3 free base) (Rac)-IBT6A hydrochloride	Others	Others
	(Rac)-IBT6A hydrochloride is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib. IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM).
T73276	BTK-IN-23
	BTK-IN-23 是一种BTK 抑制剂 (IC50: 12.8 nM)。BTK-IN-23 还抑制 BLX 和 BMX，IC50分别为 35.6 和 5.7 nM。与 Ibrutinib 相比，BTK-IN-23 显示出更高的激酶选择性。
T73275	BTK-IN-22
	BTK-IN-22 是一种BTK 抑制剂 (IC50: 12.8 nM)。BTK-IN-22 还抑制 BLX 和 BMX，IC50分别为 35.6 和 5.7 nM。与 Ibrutinib 相比，BTK-IN-22 显示出更高的激酶选择性。
T70668	GNE-431
	GNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM. GNE-431 showed excellent potency against the C481R, T474I, and T474M mutants. GNE-431 may provide a treatment option to patients, especially those who have acquired resistance to ibrutinib by mutation of Cys481 or Thr474.
T35481	DD 03-171
	Potent and selective BTK Degrader (IC50 = 5.1 nM); degrades BTK in a proteasome- and CRBN-dependent manner. Suppresses BTK signaling and proliferation in mantle cell lymphoma (MCL) cells by degrading BTK, IKFZ1, and IKFZ3 (3 validated targets in B-cell malignancies). Also degrades Ibrutinib (Cat. No. 6813) -resistant C481S-BTK mutant cancer cells. Exhibits no binding against a panel of 468 kinases at 1 μM. Reduces tumor burden and extends survival in lymphoma patient-derived xenograft models.
T16583	Propargyl-PEG1-acid	Others	Others
	Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1].
T16614	Propargyl-PEG4-acid	Others	Others
	Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib -based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1].
T70446	Abivertinib HCl
	Abivertinib, also known as AC0010 and Avitinib, is a third-generation EGFR tyrosine kinase inhibitor and BTK Inhibitor that demonstrated clinical efficacy and manageable adverse events (AEs). Abivertinib inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AML cells, especially those harboring FLT3-ITD mutations. Abivertinib was also found to be more sensitive than ibrutinib in treating AML. Abivertinib may be a promising novel agent for A...
T70677	PLS-123
	PLS-123 is a novel covalent irreversible Btk inhibitor with potential anti-proliferative activity. PLS-123 exhibited more potent anti-proliferative effects than ibrutinib in multiple cellular and in vivo preclinical models of B-cell lineage malignancy, including 14 kinds of cell lines, patients’ primary tumor cells and mouse xenograft model.

化合物

Cat.No: T1835

Synonym: 伊布替尼,依鲁替尼,PCI-32765

Target: Tyrosine Kinases, Src, BTK, Ligands for Target Protein for PROTAC

N-piperidine Ibrutinib

Cat.No: T9408

Target: BTK

N-piperidine Ibrutinib hydrochloride

Cat.No: T12152

Target: BTK

Ibrutinib deacryloylpiperidine

Cat.No: T8636

Synonym: IBT4A,5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine,伊布替尼中间体N-2

Target: BTK

Cat.No: T11601

Synonym: PCI-32765 D5,Ibrutinib D5

Target: Others

Ibrutinib dimer

Cat.No: T11602

Target: Others

Dihydrodiol-Ibrutinib

Cat.No: T36429

Ibrutinib-MPEA

Cat.No: T11603

Target: Others

Ibrutinib-biotin

Cat.No: T18049

Target: Others

Ibrutinib Racemate

Cat.No: T16440

Synonym: PCI-32765 (Racemate)

Target: Others

Ibrutinib Interm 0441

Cat.No: T21357

Synonym: (S)-1-Boc-3-hydroxypiperidine,(S)-1-Boc-3-piperidinol

Cat.No: T16730

Target: BTK

Cat.No: T10626

Target: Others, BTK

Cat.No: T10625

Synonym: 依鲁替尼中间体

Target: BTK

IBT6A hydrochloride

Cat.No: T10625L2

Target: Others

(Rac)-IBT6A hydrochloride

Cat.No: T73942

(Rac)-IBT6A hydrochloride (1412418-47-3 free base)

Cat.No: T10625L

Synonym: (Rac)-IBT6A hydrochloride

Target: Others

Cat.No: T73276

Cat.No: T73275

Cat.No: T70668

Cat.No: T35481

Propargyl-PEG1-acid

Cat.No: T16583

Target: Others

Propargyl-PEG4-acid

Cat.No: T16614

Target: Others

Abivertinib HCl

Cat.No: T70446

Cat.No: T70677

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