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Search Results for " igf1 "

Targets Recommended: IGF-1R

4

抑制剂 & 化合物

1

天然产物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T76810	Ganitumab AMG 479	IGF-1R	Tyrosine Kinase/Adaptors
	Ganitumab (AMG 479) 是一种高效的1型胰岛素样生长因子受体 (IGF1R) 单克隆抗体。Ganitumab 在低浓度下识别与 IGF1R 结合，KD 值为0.22 nM，Ganitumab 对小鼠 IGF1R 与 IGF1 和 IGF2 的相互作用有抑制作用。Ganitumab 可用于研究癌症。
T76795	Xentuzumab BI 836845	Akt; IGF-1R	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Xentuzumab (BI836845) 是人源化IGF 配体的重组单克隆抗体，抑制 IGF1 和 IGF2 促生长信号传导，抑制 AKT 的激活，可用于研究实体肿瘤。
T76746	Figitumumab
	Figitumumab (CP-751871) 为一种高效对抗胰岛素样生长因子 1 受体 (IGF1R) 的全人单克隆抗体。通过阻断 IGF1 与 IGF1R 的结合，其 IC50 值达到 1.8 nM。
T80605	Dusigitumab MEDI 573	IGF-1R	Tyrosine Kinase/Adaptors
	Dusigitumab (MEDI 573)为一种人源化IgG2λ单克隆抗体，具有特异性针对IGF2和IGF1。

化合物

Cat.No: T76810

Synonym: AMG 479

Target: IGF-1R

Cat.No: T76795

Synonym: BI 836845

Target: Akt, IGF-1R

Cat.No: T76746

Cat.No: T80605

Synonym: MEDI 573

Target: IGF-1R

Cat. No.	Product Name	Target	Signaling Pathways
T3871	Daucosterol Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A,西托糖苷	Glucosidase	Metabolism
	Daucosterol (Sitogluside) 是天然的甾醇体类化合物。

天然产物

Cat.No: T3871

Synonym: Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A,西托糖苷

Target: Glucosidase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06982	IGF1/IGF-I Protein, Human, Recombinant insulin-like growth factor 1,somatomedin C,胰岛素样生长因子...	Human	E. coli
	IGF1/IGF-I Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.8 KDa. and the accession number is P05019-1.
TMPY-00834	IGF1R/CD221 Protein, Human, Recombinant (His) IGF-I R,IGFR,IGFIR,IGF	Human	HEK293 Cells
	IGF1R/CD221 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81 kDa and the accession number is P08069.
TMPY-04878	IGF1/IGF-I Protein, Mouse, Recombinant insulin-like growth factor 1 (somatomedin C),Ig...	Mouse	P. pastoris (Yeast)
	IGF1/IGF-I Protein, Mouse, Recombinant is expressed in yeast. The predicted molecular weight is 7.7 kDa and the accession number is E9PU89.
TMPY-04942	IGF1 LR3 Protein, Human, Recombinant IGF‑I,insulin-like growth factor 1 (somato...	Human	P. pastoris (Yeast)
	IGF1 LR3 Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 9.1 kDa and the accession number is P05019-1.
TMPY-04360	IGF1R/CD221 Protein, Human, Recombinant (His & GST) JTK13,insulin-like growth factor 1 recepto...	Human	Baculovirus Insect Cells
	IGF1R/CD221 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 74.6 kDa and the accession number is P08069.
TMPJ-00781	LR3-IGF-1 Protein, Mouse, Recombinant (His) IGF1,insulin-like growth factor 1...	Mouse	E. coli
	Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. IG...
TMPY-06905	IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated CD221,insulin-like growth factor 1 recepto...	Human	HEK293 Cells
	IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 106.14 kDa and the accession number is NP_000866.1.
TMPH-03314	IGF1/IGF-I Protein, Rat, Recombinant (GST)	Rat	E. coli
	N/A. IGF1/IGF-I Protein, Rat, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 34.7 kDa and the accession number is P08025.
TMPH-00273	IGF1/IGF-I Protein, Bovine, Recombinant (hFc)	Bovine	P. pastoris (Yeast)
	IGF1/IGF-I Protein, Bovine, Recombinant (hFc) is expressed in yeast with N-hFc tag. The predicted molecular weight is 34.3 kDa and the accession number is P07455.
TMPK-00083	IGF1/IGF-I Protein, Human, Recombinant (hFc) IGF1A,胰岛素样生长因子,IBP1,IGF-...	Human	HEK293 Cells
	The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins.Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes.
TMPK-00455	IGF1R/CD221 Protein, Human, Recombinant (His & Avi) MGC142172,IGF-I receptor,IGF<...	Human	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R/CD221 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells wi...
TMPY-06195	IGF1R/CD221 Protein, Mouse, Recombinant (His) insulin-like growth factor 1 receptor,CD221	Mouse	HEK293 Cells
	IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 105.2 kDa and the accession number is E9QNX9.
TMPK-00658	IGF1R/CD221 Protein, Cynomolgus, Recombinant (His) CD221,IGFR,IGF1R,MGC...	Cynomolgus	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R/CD221 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells wit...
TMPK-00456	IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated CD221,MGC142172,IGFIR,	Human	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated is expressed in ...
TMPY-04552	AKT1 Protein, Human, Recombinant (His) RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1<...	Human	Baculovirus Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac...
TMPH-01536	ITGB4 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
TMPH-03390	TRPV2 Protein, Rat, Recombinant (His)	Rat	E. coli
	Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. TRPV2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 88.2 kDa and th...
TMPY-02194	SOCS3 Protein, Human, Recombinant (His & Trx) SOCS-3,SSI-3,ATOD4,Cish3,SSI3,suppressor of cytokine signali...	Human	E. coli
	Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. ...

重组蛋白

IGF1/IGF-I Protein, Human, Recombinant

Cat.No: TMPY-06982

Species: Human

Expression System: E. coli

IGF1R/CD221 Protein, Human, Recombinant (His)

Cat.No: TMPY-00834

Species: Human

Expression System: HEK293 Cells

IGF1/IGF-I Protein, Mouse, Recombinant

Cat.No: TMPY-04878

Species: Mouse

Expression System: P. pastoris (Yeast)

IGF1 LR3 Protein, Human, Recombinant

Cat.No: TMPY-04942

Species: Human

Expression System: P. pastoris (Yeast)

IGF1R/CD221 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04360

Species: Human

Expression System: Baculovirus Insect Cells

LR3-IGF-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00781

Species: Mouse

Expression System: E. coli

IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06905

Species: Human

Expression System: HEK293 Cells

IGF1/IGF-I Protein, Rat, Recombinant (GST)

Cat.No: TMPH-03314

Species: Rat

Expression System: E. coli

IGF1/IGF-I Protein, Bovine, Recombinant (hFc)

Cat.No: TMPH-00273

Species: Bovine

Expression System: P. pastoris (Yeast)

IGF1/IGF-I Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00083

Species: Human

Expression System: HEK293 Cells

IGF1R/CD221 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00455

Species: Human

Expression System: HEK293 Cells

IGF1R/CD221 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06195

Species: Mouse

Expression System: HEK293 Cells

IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00658

Species: Cynomolgus

Expression System: HEK293 Cells

IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated

Cat.No: TMPK-00456

Species: Human

Expression System: HEK293 Cells

AKT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04552

Species: Human

Expression System: Baculovirus Insect Cells

ITGB4 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01536

Species: Human

Expression System: E. coli

TRPV2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03390

Species: Rat

Expression System: E. coli

SOCS3 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPY-02194

Species: Human

Expression System: E. coli

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