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Cat. No.	Product Name	Target	Signaling Pathways
T63416	HDAC-IN-39
	HDAC-IN-39 是 HDAC 的有效抑制剂，能够作用于HDAC1、HDAC2、HDAC3，他们的IC50值分别为 1.07 μM、1.47 μM 和 2.27 μM。HDAC-IN-39 能够诱导细胞周期阻滞在 G2/M 期，同时也能够明显抑制微管聚合。HDAC-IN-39 对耐药癌细胞表现出良好的抗癌作用。
T2078	Fimepinostat CUDC-907,PI3K/HDAC Inhibitor,CUDC 907	Apoptosis; PI3K; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Fimepinostat (CUDC 907) 是一种 I 型PI3K 及 I 和 II 型HDAC 酶抑制剂，作用于 PI3Kα/PI3Kβ/PI3Kδ 和 HDAC1/HDAC2/HDAC3/HDAC10 ，IC50分别为 19/54/39 nM 和 1.7/5.0/1.8/2.8 nM。
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...