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15

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9124	Laninamivir octanoate 辛酸拉尼米韦,CS-8958	Influenza Virus	Microbiology/Virology
	Laninamivir octanoate (CS-8958) 是一种长效流感神经氨酸酶抑制剂，是Laninamivir 的前药，具有优异的抗流感病毒活性。
T0994	Ketotifen fumarate HC 20511 fumarate,富马酸酮替芬	PDE; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Ketotifen fumarate (HC 20511 fumarate) 是组胺 H1 受体和炎症介质释放的环七噻吩阻滞剂。
T19849	2-PADQZ 2PADQZ,2-PADQZ
	DPQ is an antiviral compound. DPQ has also been shown to bind to a widened RNA major groove at the internal loop. DPQ acts against the H1N1 and H3N2 strains of influenza A as well as influenza B.
T37752	Aureonitol
	Aureonitol is a fungal metabolite that has been found inChaetomiumand has antiviral activity.1It inhibits replication of the influenza A subtype H3N2 with an EC50value of 30 nM at a multiplicity of infection (MOI) of 0.01. It also inhibits replication of laboratory-adapted and clinical isolates of H3N2 (EC50s = 100 and 312 nM, respectively), as well as clinical isolates of the influenza A subtype H1N1 (EC50= 417 nM). Aureonitol inhibits hemagglutination activity of H3N2 and H1N1. 1.Sacramento, C...
T14035	3M-011	TLR	Immunology/Inflammation
	3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3].
T63981	Cap-dependent endonuclease-IN-17
	Cap-dependent endonuclease-IN-17 是帽依赖性核酸内切酶 (CEN) 抑制剂。Cap-dependent endonuclease-IN-17 对流感病毒 A/Hanfang/359/95 (H3N2) 表现出抗病毒作用 (IC50: 1.29 μM)。
T74774	Neuraminidase-IN-16
	Neuraminidase-IN-16 (Compound 43b) 是一种有效的神经氨酸酶 (neuraminidase) 抑制剂，对 H5N1、H5N8、H1N1、H3N2、H5N1–H274Y 和 H1N1–H274Y 的神经氨酸酶抑制作用的 IC50分别为 0.031、0.15、0.25、0.60、0.63 和 10.08 μM。
T62216	Influenza virus-IN-5
	Influenza virus-IN-5 (Compound 5f) 是一种流感病毒血球凝集素 (hemagglutinin (HA)) 抑制剂，能够作用于 A/H3N2 病毒 (EC50: 1 nM)。
T60778	Anti-Influenza agent 3
	Anti-Influenza agent 3 (compound 11h) 是有效的抗流感药物，对 MDCK 上皮细胞显示出低细胞毒性。Anti-Influenza agent 3 抑制 M2 WT 和 S31N 离子通道的传导性。Anti-Influenza agent 3 对 A/HK/68 (H3N2, M2-WT) 菌株的 EC50值为 3.29 μM，对 A/WSN/33 (H1N1, M2-S31N) 菌株的 EC50值为 2.45 μM。
T61904	HSP90-IN-14
	HSP90-IN-14 (compound 4) 是有效的Hsp90 抑制剂（Kd= 0.26μM）。在MDCK 细胞中，HSP90-IN-14 表现出抗流感病毒活性，抗 A/H3N2、A/H1N1 和 B 型流感病毒的EC50分别为 2.6、3.9 和 17 μM。
T69398	LUN15104
	LUN15104 is a novel hemagglutinin (HA) protein inhibitor, inhibiting entry and replication of diverse influenza viruses via the HA protein, showing potent antiviral activity against diverse H1N1, H5N1, and H3N2 influenza viruses encoding HA proteins from both groups 1 and 2. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKo...
T73347	BCX-1898
	BCX-1898 是一种环戊烷衍生物，是口服有效的，选择性的流感病毒神经氨酸酶 (influenza virus neuraminidase) 抑制剂。BCX-1898 具有抗病毒活性，对 MDCK 细胞中的甲型流感病毒 (H1N1、H3N2、H5N1) 和乙型流感病毒复制的 EC50值为 <0.01-21 μM。BCX-1898 显示出对小鼠流感模型的保护作用。
T37330	Pyridindolol
	Pyrindolol is a bacterial metabolite that has been found inS. alboverticillatus.1It inhibits neutral β-galactosidase by 50% under acidic, but not neutral, conditions when used at a concentration of 2 μg/ml. It is selective for β-galactosidase isolated from bovine liver over β-galactosidases isolated from human, bovine, pig, and rat tissues and sialidases isolated fromC. perfringens,Streptomyces, and the H3N2 strain of influenza virus (IC50s = >250 μg/ml for all).1,2 1.Aoyagi, T., Kumagai, M., Ha...
T62469	RSV/IAV-IN-3
	RSV/IAV-IN-3 (compound 14'i) 是一种双重的呼吸道合胞病毒 (RSV) (EC50: 2.92 μM) 和甲型流感病毒 (IAV) (EC50: 1.90 μM) 的双重抑制剂。RSV/IAV-IN-3 对 H1N1 和 H3N2 表现出抗病毒作用，在 MDCK 细胞中的 EC50值分别为 3.25 μM 和 1.50 μM。RSV/IAV-IN-3 能够剂量依赖性地明显抑制荧光素酶的活性 (EC50: 3.89 μM)。RSV/IAV-IN-3 可以抑制 IAV 感染和 RdRp 活性，在进入后阶段抑制 IAV 和 RSV 复制。
T39778	Influenza A virus-IN-1
	Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA.

化合物

Laninamivir octanoate

Cat.No: T9124

Synonym: 辛酸拉尼米韦,CS-8958

Target: Influenza Virus

Ketotifen fumarate

Cat.No: T0994

Synonym: HC 20511 fumarate,富马酸酮替芬

Target: PDE, Histamine Receptor

Cat.No: T19849

Synonym: 2PADQZ,2-PADQZ

Cat.No: T37752

Cat.No: T14035

Target: TLR

Cap-dependent endonuclease-IN-17

Cat.No: T63981

Neuraminidase-IN-16

Cat.No: T74774

Influenza virus-IN-5

Cat.No: T62216

Anti-Influenza agent 3

Cat.No: T60778

Cat.No: T61904

Cat.No: T69398

Cat.No: T73347

Cat.No: T37330

Cat.No: T62469

Influenza A virus-IN-1

Cat.No: T39778

Cat. No.	Product Name	Target	Signaling Pathways
TN2755	2-Desoxy-4-epi-pulchellin	Anti-infection	Microbiology/Virology
	2-Desoxy-4-epi-pulchellin 是分离自 Polygonum hydropiper 的二氯甲烷可溶部分的一种化合物。
T36734	Methyl brevifolincarboxylate
	Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM. Anti-oxidant activity[1][2]. Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM. [1]. Wu QY, et al. Chromatographic fingerprint and the simultane...
T5S1708	Dendrobine	Others; Influenza Virus	Microbiology/Virology; Others
	Dendrobine 是从石斛中分离的一种生物碱，对甲型流感病毒具有抗病毒活性。
TN1245	3-Deoxysappanchalcone	Others; Akt; mTOR	Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.

天然产物

2-Desoxy-4-epi-pulchellin

Cat.No: TN2755

Target: Anti-infection

Methyl brevifolincarboxylate

Cat.No: T36734

Cat.No: T5S1708

Target: Others, Influenza Virus

3-Deoxysappanchalcone

Cat.No: TN1245

Target: Others, Akt, mTOR

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