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Search Results for " glucokinase "

34

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11418	Glucokinase activator 1	Others	Others
	Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM).
T72284	Glucokinase activator 3
	Glucokinase activator3 是Glucokinase (GK) 的一种高效全效激活剂，AC50 值为 38 nM，具有研究 2 型糖尿病潜力。
TQ0055	AMG-3969	Glucokinase	Metabolism
	AMG-3969 是一种葡萄糖激酶-葡糖激酶调节蛋白相互作用的干扰物，IC50=为4 nM。
T3312	AM-2394 AM2394	Glucokinase	Metabolism
	AM-2394 是新型的 glucokinase 激活剂 (GKA)。它能够激活葡萄糖激酶 (GK)，EC50=60 nM。
T16479	PF-04937319	Others; Glucokinase	Metabolism; Others
	PF-04937319 是一种葡萄糖激酶激活剂 (EC50 =154.4 μM)。 PF-04937319 保持降糖功效，同时降低许多其他 GKA 观察到的低血糖风险。 PF-04937319可用于治疗2型糖尿病的研究。
T3104	Globalagliatin LY2608204	Glucokinase	Metabolism
	Globalagliatin (LY2608204) 是一种葡萄糖激酶 (GK) 活化剂，EC50=42 nM。
T15159	Dorzagliatin HMS5552	Glucokinase	Metabolism
	Dorzagliatin (HMS5552) 是双重作用的葡萄糖激酶 (glucokinase;GK) 激活剂，可改善 2 型糖尿病的血糖控制，提高胰腺 β 细胞功能。
T26712	AZD-1656 AZD 1656	Glucokinase	Metabolism
	AZD-1656 是口服有效的葡萄糖激酶选择性激活剂，EC50为 60 nM。AZD1656在2 型糖尿病中有研究的价值。
T12056	MK-0941 free base	Glucokinase	Metabolism
	MK-0941 free base 是一种口服具有活力的葡糖激酶抑制剂，在葡萄糖浓度为 2.5 和 10 mM 的条件下，对重组人 glucokinase 的EC50值分别为 240 和 65 nM。它具有较强的降血糖特性，是研究 2 型糖尿病的候选药物。
T68762	LY-2599506
	LY-2599506 is a novel glucokinase activator.
T30142	ARRY-403 AMG-151,ARRY 403,ARRY403,ARRY-403,AMG151,AMG 151	Glucokinase	Metabolism
	ARRY-403 是一种新型葡萄糖激酶激活剂，可降低 2 型糖尿病患者的空腹和餐后血糖，可用于治疗糖尿病。
T77784	WAY-297848	Glucokinase	Metabolism
	WAY-297848 是一种新型的 glucokinase 激活剂，可用于预防或治疗高血糖、糖尿病、肥胖症、血脂异常和代谢综合征。
T3104L	(1S,2R)-Globalagliatin (1S,2R)-Globalagliatin（1S,2R-1234703-40-2）	Glucokinase	Metabolism
	(1S,2R)-Globalagliatin 是一种高效的葡萄糖激酶 (GK) 激活剂，可用于研究 2 型糖尿病。
T14212	AMG-1694	Glucokinase	Metabolism
	AMG-1694 是一种强效的葡萄糖激酶-葡萄糖激酶调节蛋白（GK-GKRP）干扰物，能促进 GK-GKRP 复合物的解离，其 IC50 值为 7 nM，从而间接提高 GK 酶的活性。AMG-1694 可使几种啮齿动物糖尿病模型的血糖水平恢复正常，并降低糖尿病动物而非正常血糖动物的血糖。AMG-1694 能有效逆转 GKRP 对 GK 活性的抑制作用，并促进 GK 转位。
T29974	AMG-7549
	AMG-7549 is a disrupter of Glucokinase−Glucokinase Regulatory Protein (GK−GKRP) binding.
T68244	PF-04279405
	PF-04279405 is a potent and selective glucokinase activator.
T10092	PSN-GK1	Others	Others
	PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM).
T28781	Sinogliatin HMS-5552,RO 5305552,HMS5552,RO5305552,HMS 5552,RO-5305552
	Sinogliatin, a glucokinase activator, is used potentially for the treatment of type 2 diabetes.
T23765	AZD1092 AZD 1092,AZD-1092
	AZD1092 is the glucokinase enzyme activator.
T16480	PF-04991532	Glucokinase	Metabolism
	PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.
T25451	GKA-22 GKA22,GKA 22
	GKA-22 is a human glucokinase allosteric activator in the absence of glucose.
T25452	GKA-71 GKA 71
	GKA-71 is an effective glucokinase activator (GKA).
T32612	LBX192 NVP-LBX-192,LBX-192,LBX 192,NVP-LBX192,NVP-LBX 192
	LBX192( NVP-LBX192) is a liver-targeted glucokinase activator.
T11401	GKA50	Others	Others
	GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose).
T64046	BMS-820132
	BMS-820132 是一种葡萄糖激酶 (glucokinase) 激活剂 (AC50: 29 nM)。
T10362	AR453588	Others	Others
	AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.
T10362L	AR453588 hydrochloride	Others	Others
	AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.
T26718	AZD6370 AZD-6370,AZD 6370
	AZD-6370 is a glucokinase activator. AZD-6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food. AZD-6370 do not affect the central counterregulatory response to hypoglycemia
T12057	MK-0941	Others	Others
	MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.
T70639	AM-9514
	AM-9514 is a novel, potent Glucokinase (GK) activator. AM-9514 showed a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust efficacy in a rodent PD model. Glucokinase (GK) activators represent a class of type 2 diabetes therapeutics actively pursued due to the central role that GK plays in regulating glucose homeostasis.
T70391	AMG151 HCl
	ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesse...
T72743	(R)-PF-04991532
	(R)-PF-04991532 是PF-04991532 的 R 型异构体。PF-04991532 是一种有效的肝选择性葡萄糖激酶激活剂。
T68976	Piragliatin
	Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus. Piragliatin has an acute glucose-lowering action in patients with mild type 2 diabetes, mainly mediated through a generalized enhancement of β-cell function and through fasting restricted changes in ...
T63019	GKA50 quarterhydrate
	GKA50 quarterhydrate 是一种有效的葡萄糖激酶激活剂，其 EC50 值为 33 nM。GKA50 quarterhydrate 是一种啮齿动物和人类胰岛中 β 细胞代谢的葡萄糖样激活剂，也是一种 Ca2+依赖性胰岛素分泌调节剂。GKA50 quarterhydrate 能够刺激小鼠胰岛分泌胰岛素，可以显著降低高脂喂养的雌性大鼠血糖。

化合物

Glucokinase activator 1

Cat.No: T11418

Target: Others

Glucokinase activator 3

Cat.No: T72284

Cat.No: TQ0055

Target: Glucokinase

Cat.No: T3312

Synonym: AM2394

Target: Glucokinase

Cat.No: T16479

Target: Others, Glucokinase

Cat.No: T3104

Synonym: LY2608204

Target: Glucokinase

Cat.No: T15159

Synonym: HMS5552

Target: Glucokinase

Cat.No: T26712

Synonym: AZD 1656

Target: Glucokinase

MK-0941 free base

Cat.No: T12056

Target: Glucokinase

Cat.No: T68762

Cat.No: T30142

Synonym: AMG-151,ARRY 403,ARRY403,ARRY-403,AMG151,AMG 151

Target: Glucokinase

Cat.No: T77784

Target: Glucokinase

(1S,2R)-Globalagliatin

Cat.No: T3104L

Synonym: (1S,2R)-Globalagliatin（1S,2R-1234703-40-2）

Target: Glucokinase

Cat.No: T14212

Target: Glucokinase

Cat.No: T29974

Cat.No: T68244

Cat.No: T10092

Target: Others

Cat.No: T28781

Synonym: HMS-5552,RO 5305552,HMS5552,RO5305552,HMS 5552,RO-5305552

Cat.No: T23765

Synonym: AZD 1092,AZD-1092

Cat.No: T16480

Target: Glucokinase

Cat.No: T25451

Synonym: GKA22,GKA 22

Cat.No: T25452

Synonym: GKA 71

Cat.No: T32612

Synonym: NVP-LBX-192,LBX-192,LBX 192,NVP-LBX192,NVP-LBX 192

Cat.No: T11401

Target: Others

Cat.No: T64046

Cat.No: T10362

Target: Others

AR453588 hydrochloride

Cat.No: T10362L

Target: Others

Cat.No: T26718

Synonym: AZD-6370,AZD 6370

Cat.No: T12057

Target: Others

Cat.No: T70639

Cat.No: T70391

(R)-PF-04991532

Cat.No: T72743

Cat.No: T68976

GKA50 quarterhydrate

Cat.No: T63019

Cat. No.	Product Name	Target	Signaling Pathways
T19500	Palmitelaidic Acid trans-Palmitoleic acid,9-trans-Hexadecenoic acid,软脂酸	Glucokinase; AMPK; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	trans-Palmitelaidic Acid (trans-Palmitoleic acid) 是palmitoleic acid 的反式异构体。Palmitoleic acid 是血清和组织中最丰富的脂肪酸之一。
T4726	D-Glucose 6-phosphate sodium G6P sodium salt,D-Glucose 6-phosphate sodium salt,D-葡萄糖-6-磷酸钠盐,Sodium Glucose-6-Phosphate	Others; Endogenous Metabolite	Metabolism; Others
	D-Glucose 6-phosphate sodium (G6P sodium salt) 是内源性代谢产物的一种。
T5069	D-Glucose 6-phosphate potassium salt	Others	Others
	在细胞中，当葡萄糖被己糖激酶或葡萄糖激酶磷酸化或在糖原分解过程中通过磷酸葡萄糖变位酶转化葡萄糖 1-磷酸时，会产生D-glucose 6-phosphate (G6P)。 G6P 位于糖酵解和戊糖磷酸途径的起点。当血糖水平高时，它也可以作为糖原储存。

天然产物

Palmitelaidic Acid

Cat.No: T19500

Synonym: trans-Palmitoleic acid,9-trans-Hexadecenoic acid,软脂酸

Target: Glucokinase, AMPK, PPAR

D-Glucose 6-phosphate sodium

Cat.No: T4726

Synonym: G6P sodium salt,D-Glucose 6-phosphate sodium salt,D-葡萄糖-6-磷酸钠盐,Sodium Glucose-6-Phosphate

Target: Others, Endogenous Metabolite

D-Glucose 6-phosphate potassium salt

Cat.No: T5069

Target: Others

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