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Cat. No. | Product Name | Target | Signaling Pathways |
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T35773 |
Gliotoxin-13C13
Gliotoxin-13C13 |
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Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with diverse biological activities.1,2,3,4,5,6,7,8It inhibits 20S proteasomal chymotrypsin activity (IC50= 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutr... | |||
T70594 |
Gliotoxin monoacetate
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Gliotoxin monoacetate is a toxin found in Aspergillus. It induces apoptosis in cervical cancer cells and chondrosarcoma cells, suppresses the adaptive immune response in leukocytes, and inhibits the proteasome in Plasmodium falciparum. | |||
T70592 |
Makaluvamine A
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Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors. |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN1694 |
Gliotoxin
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Apoptosis; NF-κB; Wnt/beta-catenin; COX; PKA; Antibacterial; Antifection | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors |
Gliotoxin 是一种次生代谢产物,由A. fumigatus 分泌,可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性,从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度,调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞。 | |||
TN3520 | Bisdethiobis(methylthio)gliotoxin | PAFR | GPCR/G Protein |
Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist. |