首页工具

登录

搜索结果

Search Results for " grp78 "

13

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T67897	GRP78-IN-3	HSP	Cytoskeletal Signaling; Metabolism
	GRP78-IN-3(化合物8)是一种有效的Hsp70底物结合的小分子竞争性抑制剂，是一种选择性的Grp78 (HSPA5)抑制剂，IC50为0.59 μM。GRP78-IN-3对HspA5的选择性是HspA9的7倍(IC50为4.3 μM)，对HspA5的选择性是HspA2的20倍(IC50为13.9 μM)。
T63243	GRP78-IN-2
	GRP78-IN-2 是葡萄糖调节蛋白 78 (GRP78) 抑制剂，能够优先靶向细胞表面 GRP78，具有显著的的抗血管生成和抗癌作用，且不影响其他正常细胞。
T61106	GRP78-IN-1
	GRP78-IN-1 displays interactions with specific residues on the GRP78 protein with a binding energy of -8.07 kcal/mol. This compound possesses potent cytotoxic and anti-proliferative effects on cancer cells, particularly demonstrating promising apoptosis in breast cancer cells and wound healing properties [1].
T30480	BiP inducer X BIX	Apoptosis	Apoptosis
	BiP inducer X (BIX) 是免疫球蛋白重链结合蛋白 (BiP)/GRP78 的选择性诱导剂和 ER 伴侣诱导剂。 BiP inducer X 可防止神经元和视网膜细胞系中的细胞死亡。
T8901	YUM70	Apoptosis; GPR; HSP	Apoptosis; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism
	YUM70 是一种选择性葡萄糖调节蛋白 78 抑制剂，抑制全长蛋白的 GRP78 ATPase 活性的IC50值为 1.5 μM。它在胰腺癌中诱导内质网应激介导的细胞凋亡。
T7010	VER-155008 VER155008	GPR; HSP; Autophagy	Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism
	VER-155008 是一种Hsp70的抑制剂，对Hsp70、Hsc70 和 Grp7 的IC50值分别为 0.5 μM、2.6 μM 和 2.6 μM，对Hsp70的Kd 值为 0.3 μM，比 HSP90 选择性高 100 倍以上。
T67717L	Questiomycin A derivatives 18 TFA
	Questiomycin A derivatives 18 TFA 是一种Questiomycin A 衍生物，Questiomycin A 具有抗菌和抗癌活性，对细胞保护性 ER 伴侣蛋白 GRP78 的表达具有抑制作用。
T6855	HA15	Apoptosis; GPR; Others; HSP; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism; Others
	HA15 是一种高效特异性内质网伴侣蛋白BiP/GRP78/HSPA5抑制剂，抑制 BiP 的 ATP 酶活性，具有抗肿瘤活性。
T38471	HM03 trihydrochloride
	HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.
T39423	Palmitic acid-13C sodium
	Sodium palmitate-13C is the 13C-labeled variant of palmitic acid, a long-chain saturated fatty acid prevalent in animals and plants. This compound has been shown to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in mouse granulosa cells.
T40980	Palmitic acid-13C2 Palmitic acid-13C2
	Palmitic acid-13C2 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
T40141	Palmitic acid-13C16 sodium Palmitic acid-13C16 sodium
	Palmitic acid-13C16 sodium, a 13C-labeled form of the naturally occurring saturated fatty acid Palmitic acid sodium, is prevalent in animals and plants. This compound can trigger the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells.
T72543	BOLD-100 free base NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base
	BOLD-100 (NKP-1339; IT-139) free base 是一款钌基抗癌药物。作为GRP78应激诱导上调的抑制剂，它破坏内质网(ER)的稳态，从而诱发ER应激和未折叠蛋白反应(UPR)。此外，BOLD-100 free base 干预了内质网应激反应、溶酶体动力学以及细胞自噬(autophagy)间的复杂交互作用。

化合物

Cat.No: T67897

Target: HSP

Cat.No: T63243

Cat.No: T61106

Cat.No: T30480

Synonym: BIX

Target: Apoptosis

Cat.No: T8901

Target: Apoptosis, GPR, HSP

Cat.No: T7010

Synonym: VER155008

Target: GPR, HSP, Autophagy

Questiomycin A derivatives 18 TFA

Cat.No: T67717L

Cat.No: T6855

Target: Apoptosis, GPR, Others, HSP, Autophagy

HM03 trihydrochloride

Cat.No: T38471

Palmitic acid-13C sodium

Cat.No: T39423

Palmitic acid-13C2

Cat.No: T40980

Synonym: Palmitic acid-13C2

Palmitic acid-13C16 sodium

Cat.No: T40141

Synonym: Palmitic acid-13C16 sodium

BOLD-100 free base

Cat.No: T72543

Synonym: NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base

Cat. No.	Product Name	Target	Signaling Pathways
T36818	Questiomycin A	GPR; Antibacterial	Endocrinology/Hormones; GPCR/G Protein; Microbiology/Virology
	Questiomycin A 是一种在鲜奶油中生产的抗生素，具有抗菌和抗癌活性。 Questiomycin A 抑制细胞保护性 ER 伴侣蛋白 GRP78 的表达。
TN2371	Isoliquiritin 新异甘草苷,Neoisoliquiritin	Others	Others
	Neoisoliquiritigenin, isolated from Spatholobus suberectus, inhibits cell proliferation and induces cell apoptosis in breast cancer by directly binding to GRP78 to regulate the β-catenin pathway

天然产物

Cat.No: T36818

Target: GPR, Antibacterial

Cat.No: TN2371

Synonym: 新异甘草苷,Neoisoliquiritin

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼