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17

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6594	MNS	Syk; Src; p97	Angiogenesis; Tyrosine Kinase/Adaptors; Ubiquitination
	MNS 是一种酪氨酸激酶抑制剂和广谱抗血小板药物，是一种 β-硝基苯乙烯衍生物。它完全抑制 U46619 (IC50:2.1 μM)、ADP (IC50:4.1 μM)、花生四烯酸 (IC50:5.8 μM)、胶原 (IC50:7.0 μM)和凝血酶 (IC50:12.7 μM)诱导的血小板聚集，并抑制 Src (IC50:27.3 μM)、Syk (IC50:2.8 μM) 和 FAK (IC50:97.6 μM)。
TP1060	GPRP acetate (67869-62-9 free base) Pefabloc FG,Pefa 6003,GPRP acetate	Others	Others
	GPRP acetate (Pefabloc FG) 是纤维蛋白聚合抑制剂，可抑制纤维蛋白原与血小板膜糖蛋白 Ⅱb/IIIa 复合物(糖蛋白 IIb/IIIa 受体)之间的相互作用。
T6182	Tirofiban L700462,Aggrastat,替罗非班,MK383	Integrin	Cytoskeletal Signaling
	Tirofiban (L700462) 是一种非肽类选择性 GPIIb/IIIa 拮抗剂，IC50 为 9 nM，可抑制血小板聚集。
T27250	Elarofiban RWJ-53308,RWJ 53308,RWJ53308	Integrin	Cytoskeletal Signaling
	Elarofiban(RWJ-53308) 是一种新型且具有口服活性的 GPIIb/IIIa 拮抗剂。
T27250L	Elarofiban TFA Elarofiban TFA（198958-88-2 Free base）,RWJ-53308 TFA	Integrin	Cytoskeletal Signaling
	Elarofiban TFA (RWJ-53308 TFA) 是一种新型且具有口服活性和选择性的 GPIIb/IIIa 拮抗剂，可用于研究心血管疾病。
T61345L	Orbofiban TFA Orbofiban TFA(163250-90-6 Free base)	Integrin	Cytoskeletal Signaling
	Orbofiban TFA 是一种具有口服活性的GPIIb/IIIa血小板受体拮抗剂，对血小板聚集有抑制作用，可用于研究不稳定冠状动脉综合征。
T2238	Cariporide 卡立泊来德,HOE-642	Sodium Channel	Membrane transporter/Ion channel
	Cariporide (HOE-642) 是一种选择性的Na+/H+交换抑制剂。
T22807	GR 144053 trihydrochloride	Others	Others
	platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist
T24732	roxifiban DMP-754,DMP754,DMP 754
	Roxifiban 是XV459的前药，是一种抗血小板剂，对血小板糖蛋白IIb/IIIa 复合物(GPIIb/IIIa)受体具有高亲和力和特异性。
T25608	Lamifiban trifluoroacetate Lamifiban trifluoroacetate salt
	Lamifiban trifluoroacetate is an antagonist of the nonpeptide platelet fibrinogen receptor (GPIIb/IIIa).
T61345	Orbofiban
	Orbofiban 是一种口服活性血小板膜糖蛋白IIb/IIIa 拮抗剂，抑制血小板聚集。
T76287	KGDS
	KGDS 是一种合成肽，靶向于人活化血小板细胞膜上的整合素 GPIIb-IIIa。氨基酸序列：Lys-Gly-Asp-Ser。
TP2098	Echistatin Echistatin, α1 isoform
	Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3)
T73643	Orbofiban acetate
	Orbofiban acetate 是一种口服活性血小板膜糖蛋白IIb/IIIa 拮抗剂，抑制血小板聚集。
T71254	Clopidogrel HCl
	Clopidogrel HCl is the salt form of Clopidogrel (free base), an inhibitor of ADP-induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP) binding to its receptor and of the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex.
T29073	UR-2922 UR 2922
	UR-2922 is an oral antagonist of platelet GPIIb/IIIa. UR-2922 possessed a high affinity for the human platelet receptor (K(d) <1 nM) and a slow dissociation rate (k(off)= 90 min) in vitro. UR-2922 induced no ligand-induced binding sites (LIBS) expression
T29074	UR-3216
	UR-3216, a prodrug, is a selective and orally active platelet surface glycoprotein (GPIIb/IIIa) receptor antagonist. UR-3216 is the very tight binding of its active metabolite to platelets (Ki for resting platelets is < 1 nM). UR-2992, the active form of

化合物

Cat.No: T6594

Target: Syk, Src, p97

GPRP acetate (67869-62-9 free base)

Cat.No: TP1060

Synonym: Pefabloc FG,Pefa 6003,GPRP acetate

Target: Others

Cat.No: T6182

Synonym: L700462,Aggrastat,替罗非班,MK383

Target: Integrin

Cat.No: T27250

Synonym: RWJ-53308,RWJ 53308,RWJ53308

Target: Integrin

Cat.No: T27250L

Synonym: Elarofiban TFA（198958-88-2 Free base）,RWJ-53308 TFA

Target: Integrin

Cat.No: T61345L

Synonym: Orbofiban TFA(163250-90-6 Free base)

Target: Integrin

Cat.No: T2238

Synonym: 卡立泊来德,HOE-642

Target: Sodium Channel

GR 144053 trihydrochloride

Cat.No: T22807

Target: Others

Cat.No: T24732

Synonym: DMP-754,DMP754,DMP 754

Lamifiban trifluoroacetate

Cat.No: T25608

Synonym: Lamifiban trifluoroacetate salt

Cat.No: T61345

Cat.No: T76287

Cat.No: TP2098

Synonym: Echistatin, α1 isoform

Orbofiban acetate

Cat.No: T73643

Clopidogrel HCl

Cat.No: T71254

Cat.No: T29073

Synonym: UR 2922

Cat.No: T29074

Cat. No.	Product Name	Target	Signaling Pathways
TN5221	(-)-Variabilin
	Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro a...

天然产物

Cat.No: TN5221

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