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16

抑制剂 & 化合物

34

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3124	Carbendazim Bavistin,Carbendazole,多菌灵,Mercarzole	Antifungal	Microbiology/Virology
	Carbendazim (Mercarzole) 是一种具有抗肿瘤活性的苯并咪唑衍生物，可用于癌症研究。它是一种口服广谱苯并咪唑杀菌剂，可作为真菌疾病研究的杀虫剂。
T24214	Phenamacril JS39919,苯那普利,JS399 19	Myosin; Antifungal	Cytoskeletal Signaling; Microbiology/Virology
	Phenamacril (JS39919) 是一种氰基丙烯酸酯类杀菌剂，对镰刀菌，特别是禾谷镰刀菌有很强的抑制作用。它是一种特异性镰刀菌肌球蛋白 I 抑制剂。
T14523	Beauvericin	Others; Acyltransferase	Metabolism; Others
	Beauvericin 是一种镰刀菌霉菌毒素。Beauvericin 在大鼠肝微粒体酶实验中对酰基-CoA：胆固醇酰基转移酶（ACAT）有抑制作用，其 IC50 值为 3 μM。
T27300	Olorofim Olorofim,F901318,F-901318
	Olorofim 是一种新型的选择性抗真菌化合物，对烟曲霉DHODH 具有抑制作用（IC50：44 nM），对人类DHODH 几乎没有抑制作用（>100 uM）。Olorofim 对青霉菌属、皮炎杆菌属、镰刀菌属等各种致病性丝状和二形真菌有很好的疗效。
T33468	Monoacetoxyscirpenol 4-Acetoxyscirpenol
	Monoacetoxyscirpenol is a mycotoxin produced by Fusarium roseum Gibbosum.
T40396	FgGpmk1-IN-1 FgGpmk1-IN-1
	FgGpmk1-IN-1 is a new inhibitor of the fusarium graminearum mitogen-activated protein kinase (FgGpmk1), displaying a potency with an EC50 value of 3.46 μg/mL.
T79765	SDH-IN-9
	SDH-IN-9 (compound Ip)作为Succinate Dehydrogenase的有效抑制剂，对Fusarium graminearum Schw展现出了0.93 μg/mL的EC50值。
T83070	Antifungal agent 63
	Antifungalagent 63 (Compound 3i) 是针对 Fusarium oxysporum f.sp. cucumerinum 展现出优异杀菌活性的抗真菌剂，适用于抗病毒与杀菌领域的研究。
T79522	Antifungal agent 65
	Antifungalagent 65 (Compound 5d) 是一种针对Fusarium oxysporum f.sp. cucumerinum表现出优异杀菌活性的抗真菌化合物，可应用于抗病毒与杀菌研究。
T79521	Antifungal agent 64
	Antifungalagent 64 (Compound 5c) 对Fusarium oxysporum f.sp. cucumerinum 表现出优异的抗菌活性，主要应用于抗病毒和杀菌领域的研究。
T83071	Antifungal agent 62
	Antifungalagent 62 (Compound 3a) 是针对Fusarium oxysporum f.sp. cucumerinum展现出卓越抑制效果的杀菌剂，适用于抗病毒及杀菌机制研究。
T40124	Antifungal agent 20
	Antifungal agent 20 demonstrates significant antifungal efficacy against a range of fungal pathogens including Colletotrichum gloeosprioides, Rhizoctonia solani, Phytophthora nicotianae var. nicotianae, Diplodia pinea, Colletotrichum acutatum, and Fusarium oxysporum f. sp. niveum.
T78893	Antifungal agent 78
	Antifungalagent 78（compound 25am）作为一种抗真菌剂，其针对禾谷镰刀菌具有EC50值为13.46 μM。
T35515	3-Acetyldeoxy Nivalenol-13C17 3-Acetyldeoxy Nivalenol-13C17
	3-Acetyldeoxy nivalenol-13C17is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50= 70 mg/kg) in mice.2 1.Jiao, F., Kawakami, A., and Nakajima, T.Effects of different carbon sources on trichothecene production and Tri gene expression by Fusarium grami...
T35757	Beauvericin A
	Beauvericin A is a cyclodepsipeptide and derivative of beauvericin originally isolated fromB. bassianathat has diverse biological activities.1,2,3It is active againstM. tuberculosis(MIC = 25 μg/ml) andP. falciparum(IC50= 12 μg/ml).2Beauvericin A is toxic to brine shrimp (LD100= 32 μg/ml).3 1.Gupta, S., Montillor, C., and Hwang, Y.-S.Isolation of Novel Beauvericin Analogues from the Fungus Beauveria bassianaJ. Nat. Prod.58(5)733-738(1995) 2.Nilanonta, C., Isaka, M., Kittakoop, P., et al.Antimycob...
T35775	HT-2 Toxin-13C22 HT-2 Toxin-13C22
	HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human...

化合物

Cat.No: T3124

Synonym: Bavistin,Carbendazole,多菌灵,Mercarzole

Target: Antifungal

Cat.No: T24214

Synonym: JS39919,苯那普利,JS399 19

Target: Myosin, Antifungal

Cat.No: T14523

Target: Others, Acyltransferase

Cat.No: T27300

Synonym: Olorofim,F901318,F-901318

Monoacetoxyscirpenol

Cat.No: T33468

Synonym: 4-Acetoxyscirpenol

Cat.No: T40396

Synonym: FgGpmk1-IN-1

Cat.No: T79765

Antifungal agent 63

Cat.No: T83070

Antifungal agent 65

Cat.No: T79522

Antifungal agent 64

Cat.No: T79521

Antifungal agent 62

Cat.No: T83071

Antifungal agent 20

Cat.No: T40124

Antifungal agent 78

Cat.No: T78893

3-Acetyldeoxy Nivalenol-13C17

Cat.No: T35515

Synonym: 3-Acetyldeoxy Nivalenol-13C17

Cat.No: T35757

HT-2 Toxin-13C22

Cat.No: T35775

Synonym: HT-2 Toxin-13C22

Cat. No.	Product Name	Target	Signaling Pathways
T24196	Javanicin HSDB-3501,BRN 2296055,HSDB 3501,Javanicin (Fusarium),HSDB3501
	Javanicin is an Antibacterial Naphthaquinone.
TN3112	5-Heneicosylresorcinol	NADPH-oxidase; Antifection	Immunology/Inflammation; Microbiology/Virology
	5-Heneicosylresorcinol 对 RBL-2H3 细胞中 β-己糖胺酶的释放具有抑制作用，它还可以防止 3T3-L1 细胞中甘油三酯的积累。它对红线虫、秀丽隐杆线虫和松材线虫具有杀线虫活性，ED50 值分别为 80、30 和 180 ug/mL。
T5625	Zearalenone 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2	Others	Others
	Zearalenone (F2 toxin) 是真菌毒素，主要由食物和饲料中的 Fusarium 产生。它会引起幼龄母猪乳房发育早熟或其它雌激素效应。它在猪、牛、羊体内具有雌激素活性，急性毒性低。
TN2347	Methylsticin 麻醉椒苦素,Methysticin	Others	Others
	Methylsticin (Methysticin) 是一种卡瓦内酯，从卡瓦根中分离得到。它能够抑制破骨细胞形成的活性。
T13577	β-Zearalenol	Others	Others
	β-Zearalenol, a non-steroidal estrogenic mycotoxin synthesized by Fusarium species, potentially influences transcription and affects gene expression on the translational level.
T82433	Eugenitol 7-Noreugenitin
	Eugenitol (Compound 3) 为从Diaporthe eucalyptorum分离出的抗真菌代谢产物，可抑制四种植物病原真菌（Alternaria solani, Botrytis cinerea, Fusarium solani及Gibberella saubinettii）。
T19330	Fumonisin B3 伏马菌素	Others	Others
	Fumonisin B3 is a mycotoxin derived from fusarium fungi, a member of fumonisins.
T16285	Neosolaniol	Potassium Channel	Membrane transporter/Ion channel
	Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.
T13777	Moniliformin sodium salt	Others	Others
	Moniliformin sodium salt is water-soluble mycotoxin isolate from Fusarium moniliforme.
T15357	Fumonisin B2 伏马菌素B2	Others	Others
	Fumonisin B2 is a mycotoxin produced by Fusarium moniliforme in various grains. It also is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase). Which disrupts de novo sphingolipid biosynthesis.
T13391	Zearalanone	Others	Others
	Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains.
T73893	1233B
	1233B 是丝状真菌Fusariumsp. RK97-94 的次级代谢产物。
T14548	Beta-Zearalanol	Others	Others
	Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].
TN5139	Thalifoline	Antifection	Microbiology/Virology
	Thalifoline shows antifungal activity, with 100 ug against Fusarium oxysporum f. sp. lycopersici.
T13679	Enniatin B	ERK	MAPK
	Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes.
T15356	Fumonisin B1 伏马菌素B1	Others	Others
	Fumonisin B1 is the most abundant and toxic fumonisin and is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is also a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis.
TN4588	Mulberrofuran H	Antifection	Microbiology/Virology
	Mulberrofuran H exhibits potent antifungal activity against phytopathogenic fungi Colletotrichum orbiculare, Phytophthora capsici, Corynespora cassiicola and Fusarium oxysporum.
T83158	Agistatin D
	Agistatin D，一种从镰刀菌属分离得到的吡喃缩醛类化合物，具有抑制胆固醇生物合成(cholesterolbiosynthesis)的功能。
T83157	Agistatin E
	Agistatin E是镰刀菌属分离得到的一种吡喃缩醛类化合物，具有抑制胆固醇生物合成（cholesterolbiosynthesis）的功能。
T13678	Enniatin A
	Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 22 μM in an enzyme assay using rat liver microsomes.
T5527	Anigorufone	Antifection	Microbiology/Virology
	Anigorufone is a phytoalexin, it shows striking antinematode activity. Anigorufone has shown inhibitory activity on the growth of the germinative tube of Fusarium oxysporum f. sp. cubense race 4.
T13680	Enniatin B1 恩镰孢菌素 B1	ERK	MAPK
	Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes.
T11201	Enniatin A1 恩镰孢菌素 A1	ERK	MAPK
	Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes. Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids.
T60702	Globosuxanthone A
	Globosuxanthone A 是一种具有抗癌活性的二氢黄嘌呤酮。Globosuxanthone A 对禾谷镰刀菌、茄镰刀菌和灰霉病菌表现出显著的抗真菌活性，MIC 值分别为 4、8 和 16 μg/mL。。
TN1063	Calycanthine 蜡梅碱,腊梅碱	Antifection	Microbiology/Virology
	D-calycanthine has antifungal activity, it shows significant inhibitory activities against five plant pathogenic fungi Exserohilum turcicum, Bipolaris maydis, Alternaria solani, Sclerotinia sderotiorum, and Fusarium oxysportium.
T36044	17-hydroxy Venturicidin A
	17-hydroxy Venturicidin A is a macrolide fungal metabolite originally isolated from Streptomyces. It has antibiotic activity against M. luteus, B. subtilis, and S. aureus and antifungal activity against V. dahlia, Fusarium, and C. tropicalis in a disc assay.
T13053	T-2 Toxin T-2 Mycotoxin	Others	Others
	T- 2 Toxin is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains,( LD50 are 5.2 and 1.5 mg/kg BWa in mice and rats,respectively ).
T13797	Nivalenol	Caspase	Apoptosis; Proteases/Proteasome
	Nivalenol 是一种由禾谷镰刀菌产生的真菌代谢物。 Nivalenol 通过 caspase 和内在凋亡途径诱导细胞死亡，从而影响免疫系统并引起呕吐、生长迟缓和生殖障碍。
T11219	Equisetin	Others	Others
	Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and...
T11202	Enniatin complex	Others	Others
	Enniatin complex, a mixture of cyclohexadepsipeptides predominantly derived from various Fusarium species of fungi, exhibits inhibitory effects on enzymes such as acyl-CoA: cholesterol acyl transferase. Furthermore, it has demonstrated the ability to induce apoptosis in multiple cancer cell lines. In addition to these activities, the Enniatin complex possesses ionophoric, antibiotic, and in vitro hypolipidemic properties.
TN4937	Sambutoxin	Others	Others
	Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were
T15097	Deoxynivalenol Vomitoxin,4-Deoxynivalenol
	Deoxynivalenol (Vomitoxin) 是一种单端孢菌素家族镰刀菌属产生的霉菌毒素，常见于受到污染的食物和饲料中。Deoxynivalenol 通过紧密连接处的细胞旁路来穿过肠粘膜。Deoxynivalenol 转运不受P-糖蛋白 (PgP) 或多药耐药相关蛋白 (MRP) 抑制剂的影响。Deoxynivalenol 通常会导致人类和动物腹泻、呕吐和胃肠道炎症。
T36992	Monocerin
	Monocerin is a fungal metabolite that has been found inF. larvarumand has diverse biological activities.1,2,3It is active against the bacteriaE. coliandB. megaterium, the phytopathogenic fungusM. violaceum, and the algaC. fuscain an agar diffusion assay when used at a concentration of 50 μg/disc.1Monocerin (17.5 μg/ml) induces mortality in adultC. erythrocephala.2It reduces root elongation in pre-germinatedS. halepenseseeds when used at a concentration of 33 ppm.3 1.Zhang, W., Krohn, K., Draeger...
T38069	Aquastatin A
	Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K....

天然产物

Cat.No: T24196

Synonym: HSDB-3501,BRN 2296055,HSDB 3501,Javanicin (Fusarium),HSDB3501

5-Heneicosylresorcinol

Cat.No: TN3112

Target: NADPH-oxidase, Antifection

Cat.No: T5625

Synonym: 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2

Target: Others

Cat.No: TN2347

Synonym: 麻醉椒苦素,Methysticin

Target: Others

Cat.No: T13577

Target: Others

Cat.No: T82433

Synonym: 7-Noreugenitin

Cat.No: T19330

Synonym: 伏马菌素

Target: Others

Cat.No: T16285

Target: Potassium Channel

Moniliformin sodium salt

Cat.No: T13777

Target: Others

Cat.No: T15357

Synonym: 伏马菌素B2

Target: Others

Cat.No: T13391

Target: Others

Cat.No: T73893

Beta-Zearalanol

Cat.No: T14548

Target: Others

Cat.No: TN5139

Target: Antifection

Cat.No: T13679

Target: ERK

Cat.No: T15356

Synonym: 伏马菌素B1

Target: Others

Mulberrofuran H

Cat.No: TN4588

Target: Antifection

Cat.No: T83158

Cat.No: T83157

Cat.No: T13678

Cat.No: T5527

Target: Antifection

Cat.No: T13680

Synonym: 恩镰孢菌素 B1

Target: ERK

Cat.No: T11201

Synonym: 恩镰孢菌素 A1

Target: ERK

Globosuxanthone A

Cat.No: T60702

Cat.No: TN1063

Synonym: 蜡梅碱,腊梅碱

Target: Antifection

17-hydroxy Venturicidin A

Cat.No: T36044

Cat.No: T13053

Synonym: T-2 Mycotoxin

Target: Others

Cat.No: T13797

Target: Caspase

Cat.No: T11219

Target: Others

Enniatin complex

Cat.No: T11202

Target: Others

Cat.No: TN4937

Target: Others

Cat.No: T15097

Synonym: Vomitoxin,4-Deoxynivalenol

Cat.No: T36992

Cat.No: T38069

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