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Cat. No. Product Name Target Signaling Pathways
T24438 MDK5466

MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III

MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.
T2677 Crenolanib

ARO 002,CP-868596

FLT; PDGFR; Autophagy Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
Crenolanib (ARO 002) 是一种口服生物可利用的 III 型酪氨酸激酶抑制剂,抑制 FLT3和 PDGFRα/β的 IC50分别为 4、11和 3.2 nM。
T6479 Dovitinib lactate hydrate

Dovitinib (TKI258) Lactate,多韦替尼,Dovitinib Lactate,TKI258

VEGFR; FGFR; FLT; PDGFR; c-Kit Angiogenesis; Tyrosine Kinase/Adaptors
Dovitinib lactate hydrate (TKI258) 是一种多靶点的酪氨酸激酶抑制剂,抑制 FLT3,c-Kit,FGFR1/3,VEGFR1/2/3和 PDGFRα/β的 IC50值分别为 1,2,8/9,10/13/8,27/210 nM。
T6289 Dovitinib

TKI258,多韦替尼,CHIR-258,度维替尼

VEGFR; FGFR; FLT; PDGFR; c-Kit Angiogenesis; Tyrosine Kinase/Adaptors
Dovitinib (CHIR-258) 是一种口服有效的、多靶点的酪氨酸激酶 (RTK) 抑制剂,具有抗肿瘤作用。
T71400 Quizartinib HCl

Quizartinib, also know as AC220 and AC010220, is an orally available FLT3 / STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell pro...
T6193 Dovitinib Dilactic Acid

Dovitinib (TKI-258) Dilactic Acid,TKI258 Dilactic acid

VEGFR; FGFR; FLT; c-Kit Angiogenesis; Tyrosine Kinase/Adaptors
Dovitinib Dilactic Acid (Dovitinib(TKI-258) Dilactic Acid) 是 Dovitinib 的双乳酸,是一种多靶点 RTK 抑制剂,主要用于 III 类 (FLT3/c-Kit),IC50 为 1 nM/2 nM,对 IV 类 (FGFR1/ 3) 和 V 类 (VEGFR1-4) RTK,IC50 为 8-13 nM,对 InsR、EGFR、c-Met、EphA2、Tie2、IGFR1 和 HER2 的效力较低。

化合物

MDK5466
Cat.No: T24438
Synonym: MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III
Target:
Crenolanib
Cat.No: T2677
Synonym: ARO 002,CP-868596
Target: FLT, PDGFR, Autophagy
Dovitinib lactate hydrate
Cat.No: T6479
Synonym: Dovitinib (TKI258) Lactate,多韦替尼,Dovitinib Lactate,TKI258
Target: VEGFR, FGFR, FLT, PDGFR, c-Kit
Dovitinib
Cat.No: T6289
Synonym: TKI258,多韦替尼,CHIR-258,度维替尼
Target: VEGFR, FGFR, FLT, PDGFR, c-Kit
Quizartinib HCl
Cat.No: T71400
Synonym:
Target:
Dovitinib Dilactic Acid
Cat.No: T6193
Synonym: Dovitinib (TKI-258) Dilactic Acid,TKI258 Dilactic acid
Target: VEGFR, FGFR, FLT, c-Kit
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