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Cat. No.	Product Name	Target	Signaling Pathways
T62856	FFA1 agonist-1
	FFA1 agonist-1 (Compound 17a) 是一种口服具有活力的脂肪酸受体（FFA1）激动剂 (EC50: 0.75 μM)。FFA1 agonist-1 能够用于研究 Ⅱ 型糖尿病。
TQ0020	AMG 837 calcium hydrate	GPR	Endocrinology/Hormones; GPCR/G Protein
	AMG 837 calcium hydrate 是口服有效的 GPR40/FFA1部分激动剂，抑制 [3H]AMG 837 与人类 FFA1受体的特异性结合，pIC50为 8.13。AMG 837 calcium hydrate 可增强啮齿动物的胰岛素分泌并降低葡萄糖水平。
T3171	GSK137647A GSK 137647	GPR	Endocrinology/Hormones; GPCR/G Protein
	GSK137647A (GSK 137647) 是一种选择性FFA4激动剂，作用于人类和大小鼠FFA4的pEC50分别为6.3、6.1和6.2。
T1781	GW9508 GW 9508	GPR; Potassium Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel
	GW 9508 是一种选择性 G 蛋白偶联受体FFA1(GPR40) 和GPR120激动剂。它是一种葡萄糖敏感性胰岛素促分泌剂和 ATP 敏感性钾通道开放剂，具有抗炎和抗动脉粥样硬化活性。
T7127	DC260126	Apoptosis; GPR	Apoptosis; Endocrinology/Hormones; GPCR/G Protein
	DC260126 是一种 GPR40 (FFAR1)拮抗剂，对棕榈酸酯诱导的内质网应激和凋亡有保护作用。它剂量依赖性地抑制亚油酸、油酸、棕榈油酸和月桂酸刺激的 GPR40 介导的 Ca2+升高，IC50分别 6.28、5.96、7.07和4.58 μM。
T17177	TUG-424 TUG424	Others	Others
	TUG-424 是一种有效且选择性的游离脂肪酸受体 1 (FFA1/GPR40) 激动剂，EC50 为 32 nM。TUG-424 在 100 nM 处显著增加葡萄糖刺激的胰岛素分泌。TUG-424 可能有助于探索 FFA1 在糖尿病或肥胖等代谢性疾病中的作用。
T22967	MEDICA16 MEDICA 16	GPR; Others; ATP Citrate Lyase	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Others
	MEDICA16 是 GPR40 的特异性激动剂以及 GPR120 的部分激动剂。 MEDICA16 是一种 ATP-柠檬酸裂解酶抑制剂，可显着降低腓肠肌中的细胞内 TG 含量，同时增加胰岛素敏感性。
T15810	LY2922470	GPR	Endocrinology/Hormones; GPCR/G Protein
	LY2922470 是选择性口服有效的GPR40激动剂，作用于人 GPR40、小鼠 GPR40、大鼠 GPR40 的EC50值分别为 7 nM、1 nM、3 nM。它可降低血糖水平，同时显著增加胰岛素和 GLP-1，有潜力用于 2 型糖尿病的研究。
T14200	AM-1638	GPR	Endocrinology/Hormones; GPCR/G Protein
	AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).
TQ0241	TUG-770	GPR	Endocrinology/Hormones; GPCR/G Protein
	TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1).
T2351	Fasiglifam TAK875	GPR	Endocrinology/Hormones; GPCR/G Protein
	Fasiglifam (TAK875) 是一种可口服的选择性GPR40激动剂，EC50值为 72 nM。
T62848	AMG 837 hemicalcium
	AMG 837 hemicalcium 是一种有效的、口服具有活力的 GPR40/FFA1部分激动剂。AMG 837 hemicalcium 能够抑制 [3H]AMG 837 与人类 FFA1受体的特异性结合 (pIC50: 8.13)。AMG 837 hemicalcium 能够提高啮齿动物的胰岛素分泌，减少葡萄糖水平。
T11583	HWL-088	Others	Others
	HWL-088 is a potent free fatty acid receptor 1 (FFA1/GPR40) agonist. HWL-088 significantly improves glucose tolerance in normal and diabetic models.
T35816	ZLY032
	ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic st...
T15448	GW-1100	GPR	Endocrinology/Hormones; GPCR/G Protein
	GW-1100 is a selective antagonist of GPR40 (pIC50: 6.9). GW1100 also plays the role of a GPR40 inverse agonist.
T15267	GPR40 agonist 4	Others	Others
	GPR40 agonist 4 is a potent free fatty acid agonist of receptor 1 (pEC50: 7.54).
T11459	GPR40 agonist 1	Others	Others
	GPR40 agonist 1 is an effective new GPR40 agonist (EC50s: 17 nM and 2 nM for rGPR40 and hGPR40).
T2351L	TAK-875 Hemihydrate TAK-875,Fasiglifam	GPR	Endocrinology/Hormones; GPCR/G Protein
	TAK-875 Hemihydrate (Fasiglifam) 是一种选择性 GPR40 激动剂，EC50 为 14 nM，比油酸强 400 倍。
T26868	BMS-986118 BMS 986118
	BMS-986118 is a full agonist of GPR40, is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial a
T14202	AM-4668	GPR	Endocrinology/Hormones; GPCR/G Protein
	AM-4668 is a type 2 diabetes GPR40 agonist. For GPR40, in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), the EC50s are 3.6 nM and 36 nM, respectively.
T13550	AP5	Others	Others
	AP5 is a potent and selective agonist for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49 nM against the GPR40 receptor.

化合物

FFA1 agonist-1

Cat.No: T62856

AMG 837 calcium hydrate

Cat.No: TQ0020

Target: GPR

Cat.No: T3171

Synonym: GSK 137647

Target: GPR

Cat.No: T1781

Synonym: GW 9508

Target: GPR, Potassium Channel

Cat.No: T7127

Target: Apoptosis, GPR

Cat.No: T17177

Synonym: TUG424

Target: Others

Cat.No: T22967

Synonym: MEDICA 16

Target: GPR, Others, ATP Citrate Lyase

Cat.No: T15810

Target: GPR

Cat.No: T14200

Target: GPR

Cat.No: TQ0241

Target: GPR

Cat.No: T2351

Synonym: TAK875

Target: GPR

AMG 837 hemicalcium

Cat.No: T62848

Cat.No: T11583

Target: Others

Cat.No: T35816

Cat.No: T15448

Target: GPR

GPR40 agonist 4

Cat.No: T15267

Target: Others

GPR40 agonist 1

Cat.No: T11459

Target: Others

TAK-875 Hemihydrate

Cat.No: T2351L

Synonym: TAK-875,Fasiglifam

Target: GPR

Cat.No: T26868

Synonym: BMS 986118

Cat.No: T14202

Target: GPR

Cat.No: T13550

Target: Others

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