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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T60266 |
(Rac)-Indoximod
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(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL. Moreover, this co-treatment effectively improves cardiac fibrosis[1]. | |||
T6543 |
Indoximod
NLG-8189,Indoximod (NLG-8189),1-Methyl-D-tryptophan,吲哚莫德 |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Indoximod (Indoximod (NLG-8189)) 是一种具有口服具有活力的吲哚胺2,3-双加氧酶(IDO) 途径抑制剂。它在调节 mTOR 中充当 Trp 模拟物。它是一种可用于癌症研究的免疫代谢佐剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S0290 |
Araloside A
Chikusetsusaponin IV,竹节参皂苷IV |
RAAS; Fas/FasL | Apoptosis; Endocrinology/Hormones |
Araloside A (Chikusetsusaponin IV) 是竹节参中的一种成分,对肾素renin 具有低抑制活性(IC50:77.4 μM)。 | |||
TN4496 |
Marginatoxin
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Caspase; Fas/FasL | Apoptosis; Proteases/Proteasome |
Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway. | |||
T3S1967 |
(S)-Indoximod
N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine |
Others; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism; Others |
(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂,可用于研究癌症。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03956 |
Fas Ligand Protein, Human, Recombinant (His)
TNLG1A,FASL,FASLG,CD178,CD95-L,APT1LG1,APT... |
Human | P. pastoris (Yeast) |
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protei... | |||
TMPY-04587 |
Fas Ligand Protein, Mouse, Recombinant (His)
CD178,Apt1lg1,Fasl,Cd95l,Faslg,Tnfsf6,gld,... |
Mouse | P. pastoris (Yeast) |
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protei... | |||
TMPJ-01059 |
CRADD Protein, Human, Recombinant
Caspase and RIP Adapter with Death Domain,RAIDD,RIP-Associat... |
Human | E. coli |
Death Domain-Containing Protein CRADD (CRADD) is widely expressed in most tissues, with particularly high expression in the adult heart, testis, liver, skeletal muscle, fetal liver, and kidney. CRADD contains one CARD domain that mediates the interaction with caspase-2, and one death domain involved in the binding of RIP protein. CRADD functions as an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. CRADD induces cell apoptosis/cell death in numero... | |||
TMPY-02578 |
DKKL1 Protein, Human, Recombinant (hFc)
SGY,dickkopf-like 1,CT34,SGY1,SGY-1 |
Human | HEK293 Cells |
Dickkopf-like 1 (DKKL1) or soggy 1, is a glycoprotein unique to mammals that is expressed primarily in developing spermatocytes and localized in the acrosome of mature sperm. It is also expressed in the trophectoderm / placental lineage. This glycoprotein is secreted by postmeiotic male germ cells. DKKL1 is a member of the Dickkopf (DKK) family, a group of proteins that are characterized as secreted antagonists of Wnt signal transduction proteins. In mammals, embryos lacking DKKL1 protein develo... | |||
TMPY-03521 |
DcR3 Protein, Human, Recombinant (hFc)
DCR3,tumor necrosis factor receptor superfamily member 6b,M6... |
Human | Baculovirus Insect Cells |
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) also known as DcR3(Decoy Receptor 3) and M68 is the tumor necrosis factor receptor superfamily. DcR3/TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tu... | |||
TMPY-02213 |
RAIDD Protein, Human, Recombinant (His)
RAIDD,MRT34,CASP2 and RIPK1 domain containing adaptor with d... |
Human | E. coli |
Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD / RAIDD contains oneCARD domain and onedeath domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the ... | |||
TMPY-02210 |
Serpin B9 Protein, Human, Recombinant (His)
CAP-3,PI-9,CAP3,PI9,serpin peptidase inhibitor, clade B (ova... |
Human | Baculovirus Insect Cells |
SerpinB9, also known as Cytoplasmic antiproteinase 3, CAP-3, Peptidase inhibitor 9, SERPINB9 and PI-9, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. Serpin-B9 ( CAP-3 / PI-9 ) is the only known human intracellular inhibitor of granzyme B (GrB), the effector molecule in immunity against cytomegalovirus (CMV) and in renal allograft rejection. Serpin-B9 and SPI-6 expression in immune-privileged cells, APCs, and CTLs protect these cells against the actions of gran... |