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Cat. No.	Product Name	Target	Signaling Pathways
T61018	DPP-4-IN-2
	DPP-4-IN-2 (compound b2) 是 Alogliptin 的结构类似物，可以用于研究糖尿病。DPP-4-IN-2 是二肽基肽酶 4 (DPP-4)的有效抑制剂，IC50值为 79 nM。
T11526	DPP-IV-IN-2 H-Lys(4-nitro-Z)-pyrrolidide	DPP-4	Proteases/Proteasome
	DPP-IV-IN-2 (H-Lys(4-nitro-Z)-pyrrolidide) 是二肽基肽酶 IV 和DP8/9的抑制剂， IC50分别为 0.1 和 0.95 μM。
T68053	Denagliptin GW823093	DPP-4	Proteases/Proteasome
	Denagliptin是一种小分子二肽基肽酶IV（DPP-4）抑制剂，可用于治疗内分泌于代谢疾病，可用于研究2型糖尿病。
T0242	Sitagliptin 西他列汀,MK0431,西格列汀	Proteasome; DPP-4; Autophagy	Autophagy; Proteases/Proteasome; Ubiquitination
	Sitagliptin (MK0431) 是一种有效的 DPP4抑制剂，在 Caco-2 细胞中，IC50值为 19 nM。它是一种新型口服降糖药，可单独使用或与二甲双胍或噻唑烷二酮联合用于治疗 2 型糖尿病。
T29970	AMG-222 AMG 222,ALS-2-0426 free base,ALS-2-0426,ALS-20426
	AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes.
T35815	Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)
	Vildagliptin carboxylic acid metabolite is the major metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor vildagliptin in humans. Vildagliptin carboxylic acid metabolite has an IC50 value of 477 μM for DPP-4 in human Caco-2 cells. It is formed from hydrolysis of the cyano group on vildagliptin.
T76922	Begelomab
	Begelomab (SAND-26) 是一种针对 DPP-4/CD26的鼠IgG2b 单克隆抗体。 Begelomab 可用于严重难治性特发性炎症性肌病的研究。
T62985	Cofrogliptin
	Cofrogliptin (HSK7653) (compound 2) 是一种四氢吡喃衍生物，是一种口服具有活力的 DPP-4 抑制剂，具有长效降糖作用。Cofrogliptin (compound 2) 具有潜力进行 2 型糖尿病 (T2DM) 的研究。
T73875	Fotagliptin benzoate
	Fotagliptin benzoate，作为一种二肽基肽酶IV (DPP-4) 抑制剂（IC50=2.27 nM），在大鼠和狗中展现了安全性，适用于2型糖尿病的研究。
T79256	DPP-4-IN-8
	DPP-4-IN-8 (compound 27) 是一种高效的选择性DPP4抑制剂，具有 0.96 μM 的 Ki。该化合物能够抑制 Caco-2 和 HepG-2 细胞中的 DPP4 二肽酶活性，并剂量依赖性地降低 TNF-α、IL-6 和 IL-1β 的表达水平[1]。
T6203L	Saxagliptin hydrochloride BMS477118,Saxagliptin,BMS 477118,Saxagliptin HCl,BMS-477118
	Saxagliptin is a new oral hypoglycemic of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Saxagliptin is a competitive DPP4 inhibitor that slows the inactivation of the incretin hormones and reducing fasting and postprandial glucose conce
T37522	Teneligliptin
	Teneligliptin (MP-513) is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM. Teneligliptin (MP-513) inhibits all these DPP-4 enzymes in a concentration-dependent manner. The IC50s of Teneligliptin (MP-513) for rhDPP-4, human plasma, and rat plasma are 0.889, 1.75, and 1.35 nM, respectively. A study of enzyme inhibition kinetics is conducted for Teneligliptin (M...
T78571	Albiglutide fragment TFA GLP-1-Gly8 TFA,GLP-1 (7-36) analog TFA
	Albiglutide fragment (GLP-1 (7-36) analog) TFA为Albiglutide活性片段，代表胰高血糖素样肽-1(GLP-1)模拟物，属长效GLP-1受体激动剂。由GLP-1二聚体抗DPP-4特性与人白蛋白基因融合而成，本化合物在降低糖化血红蛋白(A1C)方面表现显著，主要应用于2型糖尿病(T2D)的相关研究。
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...

化合物

Cat.No: T61018

Cat.No: T11526

Synonym: H-Lys(4-nitro-Z)-pyrrolidide

Target: DPP-4

Cat.No: T68053

Synonym: GW823093

Target: DPP-4

Cat.No: T0242

Synonym: 西他列汀,MK0431,西格列汀

Target: Proteasome, DPP-4, Autophagy

Cat.No: T29970

Synonym: AMG 222,ALS-2-0426 free base,ALS-2-0426,ALS-20426

Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)

Cat.No: T35815

Cat.No: T76922

Cat.No: T62985

Fotagliptin benzoate

Cat.No: T73875

Cat.No: T79256

Saxagliptin hydrochloride

Cat.No: T6203L

Synonym: BMS477118,Saxagliptin,BMS 477118,Saxagliptin HCl,BMS-477118

Cat.No: T37522

Albiglutide fragment TFA

Cat.No: T78571

Synonym: GLP-1-Gly8 TFA,GLP-1 (7-36) analog TFA

Cat.No: T37861

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