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Search Results for " cytarabine "

13

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1272L	Cytarabine hydrochloride Ara-C hydrochloride,Cytosine Arabinoside hydrochloride	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cytarabine hydrochloride (Ara-C hydrochloride) 是一种核苷类似物，可导致 S 期细胞周期停滞并抑制DNA 聚合酶。Cytarabine 抑制DNA 合成，IC50为 16 nM。Cytarabine hydrochloride 对HSV 具有抗病毒作用。
T38718	Cytarabine triphosphate Cytarabine triphosphate,Ara-CTP
	Cytarabine triphosphate (Ara-CTP), a competitive inhibitor of DNA synthesis and an active metabolite of Cytarabine, exhibits predictive potential for leukemic blasts' chemosensitivity to Cytarabine through intracellular levels.
T15009	Elacytarabine 5'-Oleoyl cytosine arabinoside,5'-O-(Elaidoyl) 1-beta-D-arabinofuranosylcytosine,5'-Oleoyl cytarabine,艾西拉滨,CP 4055	Others	Others
	Elacytarabine (M7594 0037) 是核苷类似物阿糖胞苷的一种脂质缀合衍生物。Elacytarabine (M7594 0037) (CP 4055) 是一种抗肿瘤药物，在实体瘤中具有细胞毒性。
T31088	CPX-351 Cytarabine/daunonubicin,Vyxeos,CPX 351,Daunonubicin/cytarabine
	CPX-351 is a Liposomal-encapsulated combination of daunorubicin and cytarabine for the treatment of newly diagnosed tAML or AML with myelodysplasia-related changes (AML-MRCs).
T29643	Adamantoylcytarabine Adamantoyl cytarabine,Adam CA
	Adamantoylcytarabine is abioactive chemical.
T15343	Fosteabine YNK 01,Cytarabine ocfosfate,阿糖胞苷烷磷酯	Others	Others
	Fosteabine is an oral and prodrug analog of cytarabine. It is resistant to deoxycytidine deaminase.
T27342L	Flurocitabine HCl Flurocitabine HCl(37717-21-8 Free base)	Others	Others
	Flurocitabine HCl 是阿糖胞苷的氟化酸酐类似物，在体内部分水解成两种活性抗肿瘤物质 (阿拉伯糖基-氟尿嘧啶 (ara-FC) 和阿拉伯糖基-氟尿嘧啶 (ara-FU))。Flurocitabine HCl 在急性白血病和实体瘤的 I 期研究中具显示出抗肿瘤活性。
T79224	Ara-SH	Apoptosis	Apoptosis
	Ara-SH为Cytarabine巯基丙酸取代的衍生物，应用于通过自组装技术制造携带Cytarabine和Venetoclax的智能共负载纳米颗粒(AV-NP)的触发器。在体外和体内实验中，Ara-SH展现出显著的协同抗白血病效果。
T11956L	MBC-11	Others	Others
	MBC-11 is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). It also has the potential to treat tumor-induced bone disease (TIBD).
T21161	Ancitabine
	Ancitabine, a congener of cyterabine, is metabolized to cytarabine, thereby maintains a more constant antineoplastic action.
T11956	MBC-11 triethylamine	Others	Others
	MBC-11 triethylamine has potential to treat tumor-induced bone disease (TIBD), is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC).
T68917	Fazarabine
	Fazarabine, also known as Kymarabine, is an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determin...
T71654	APcK110
	APcK110 is a novel Kit inhibitor . APcK110 inhibits proliferation of the mastocytosis cell line HMC1.2 and the SCF-responsive cell line OCI/AML3 in a dose-dependent manner . APcK110 is a more potent inhibitor of OCI/AML3 proliferation than the clinically used Kit inhibitors imatinib and dasatinib and at least as potent as cytarabine. APcK110 inhibits the phosphorylation of Kit, Stat3, Stat5, and Akt in a dose-dependent fashion, showing activity of APcK110 on Kit and its downstream signaling path...

化合物

Cytarabine hydrochloride

Cat.No: T1272L

Synonym: Ara-C hydrochloride,Cytosine Arabinoside hydrochloride

Target: DNA/RNA Synthesis

Cytarabine triphosphate

Cat.No: T38718

Synonym: Cytarabine triphosphate,Ara-CTP

Cat.No: T15009

Synonym: 5'-Oleoyl cytosine arabinoside,5'-O-(Elaidoyl) 1-beta-D-arabinofuranosylcytosine,5'-Oleoyl cytarabine,艾西拉滨,CP 4055

Target: Others

Cat.No: T31088

Synonym: Cytarabine/daunonubicin,Vyxeos,CPX 351,Daunonubicin/cytarabine

Adamantoylcytarabine

Cat.No: T29643

Synonym: Adamantoyl cytarabine,Adam CA

Cat.No: T15343

Synonym: YNK 01,Cytarabine ocfosfate,阿糖胞苷烷磷酯

Target: Others

Flurocitabine HCl

Cat.No: T27342L

Synonym: Flurocitabine HCl(37717-21-8 Free base)

Target: Others

Cat.No: T79224

Target: Apoptosis

Cat.No: T11956L

Target: Others

Cat.No: T21161

MBC-11 triethylamine

Cat.No: T11956

Target: Others

Cat.No: T68917

Cat.No: T71654

Cat. No.	Product Name	Target	Signaling Pathways
T1272	Cytarabine 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; HSV	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Cytarabine (Ara-C) 是一种核苷类似物，一种 DNA 合成抑制剂 (IC50=16 nM)。Cytarabine 可以抑制 DNA 聚合酶，诱导细胞周期阻滞、细胞自噬和凋亡。Cytarabine 具有抗肿瘤活性。
T1591	Ancitabine hydrochloride NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C	Others; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Ancitabine hydrochloride (NSC 145668 HCl) 是一种天然的抗白血病药物。

天然产物

Cat.No: T1272

Synonym: 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV

Ancitabine hydrochloride

Cat.No: T1591

Synonym: NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C

Target: Others, DNA/RNA Synthesis, Autophagy

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