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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6459 |
Cyclosporine
|
Phosphatase | Metabolism |
Cyclosporine 是一种钙调神经磷酸酶通路抑制剂,用作免疫抑制剂以防止器官移植中的排斥反应。 | |||
T9936 |
ZX-J-19J
N-(2,3-Diphenyl-6-quinoxalinyl)octanamide |
Others | Others |
ZX-J-19J (N-(2,3-Diphenyl-6-quinoxalinyl)octanamide) 是 Cyclophilin J 的抑制剂,对肿瘤细胞生长有显着的抑制作用,与环孢素 A 相当,但比 5-氟尿嘧啶强得多。 | |||
T70889 |
Oxeclosporin
|
||
Oxeclosporin is a hydroxyethyl derivative of serine(8)-cyclosporine; inhibits proliferation and functions of lymphocytes. | |||
T32020 |
Gusperimus
Deoxyspergualin,15-Deoxyspergualin |
||
Gusperimus was synthesized by chemical modification of spergualin and in combination with cyclosporine A to prevent diabetes in susceptible NOD mice. | |||
T28080 |
Mocravimod
KRP 203 free base,KRP-203,KRP203 |
||
Mocravimod is an agonist of sphingosine 1-phosphate receptor type 1. Mocravimod ameliorates atherosclerosis in LDL-R-/- mice. KRP-203 attenuates rat autoimmune myocarditis. KRP-203 combined with cyclosporine prolonged graft survival and abrogated transpla | |||
T34999 |
UNIL-088
UNIL 088 |
||
UNIL088 is a water-soluble prodrug of cyclosporine A (CsA) designed for topical ocular delivery. The pro-moiety is grafted via an ester function to CsA and the solubilizing group is a phosphate ion. UNIL-088 can be rapidly hydrolysed under physiological c | |||
T0679 |
Ketoconazole
R-41400,Xolegel,(±)-Ketoconazol,酮康唑,Extina |
NADPH-oxidase; P450; Hydroxylase; Antifungal; Ras | GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology |
Ketoconazole (R-41400) 是一种咪唑类抗真菌剂,也是一种 CYP3A4 抑制剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0945 |
Cyclosporin A
环孢素,Cyclosporine A,Ciclosporin,Cyclosporine,环孢菌素 |
Phosphatase; Antibiotic; Complement System | Immunology/Inflammation; Metabolism; Microbiology/Virology |
Cyclosporin A 属于天然产物,是一种真菌的活性代谢产物,一种环状多肽。Cyclosporin A 是一种能与亲环素结合的免疫抑制剂,可以抑制 calcineurin (IC50=7 nM)。 |