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Cat. No.	Product Name	Target	Signaling Pathways
T4329	CP 376395 CP-316311	CRFR	GPCR/G Protein
	CP 376395 (CP-316311)是一种 CRF1受体选择性拮抗剂。
T12492	Pivagabine CXB-722,匹伐加宾	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Pivagabine (CXB-722) 是疏水性 4-氨基丁酸的衍生物，具有神经调节活性。它可穿透大鼠的血脑屏障，拮抗足部休克对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
T7361	Verucerfont NBI77860,3-(4-甲氧基-2-甲基苯基)-2,5-二甲基-N-[(1S)-1-(3-甲基-1,2,4-恶二唑-5-基)丙基]吡唑并[1,5-A]嘧啶-7-胺,GSK561679	CRFR	GPCR/G Protein
	Verucerfont (NBI77860) 是促肾上腺皮质激素释放因子受体 1 (CRF1) 拮抗剂，作用于 CRF1(IC50:6.1 nM)，CRF2 (IC50>1000 nM)和 CRF-BP (IC50>1000 nM)。
TP1021	Urocortin, human Urocortin (human),Human urocortin,Human urocortin 1,Human urocortin I	CRFR	GPCR/G Protein
	Urocortin, human (Human urocortin I) 是由 40 个氨基酸组成的神经多肽，是选择性 CRF2受体激动剂，作用于 hCRF1(Ki:0.4 nM)、rCRF2α(Ki:0.3 nM)、 mCRF2β(Ki:0.5 nM)。
T31095	Crinecerfont SSR125543,SSR 125543,SSR-125543,SSR125543A,SSR 125543A,SSR-125543A	CRFR	GPCR/G Protein
	Crinecerfont (SSR-125543) 是促肾上腺皮质激素释放因子 1 受体 (CRF1) 的特异性拮抗剂，可用于经典先天性肾上腺增生的研究。
T16475	Pexacerfont BMS-562086	CRFR	GPCR/G Protein
	Pexacerfont (BMS-562086) 是一种选择性的促肾上腺皮质激素释放因子 (CRF1) 受体拮抗剂，作用于人 CRF1 受体，IC50 为 6.1±0.6 nM。
TP1448L	Astressin acetate Astressin acetate (170809-51-5 Free base)	CRFR	GPCR/G Protein
	Astressin acetate 是促肾上腺皮质激素释放因子 (CRF) 的拮抗剂，对 CRF 结合蛋白具有低亲和力，对克隆垂体受体具有高亲和力 (Ki = 2 nM)。
T12276	NVS-CRF38	Others	Others
	NVS-CRF38 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1).
T27227	E2508 E 2508,E-2508
	E2508 is a selective antagonist of corticotropin-releasing factor 1 receptor.
T15214	Emicerfont GW876008	Others	Others
	Emicerfont is an antagonist of the corticotropin-releasing factor type 1 receptor (IC50: 66 nM).
T26856	BMS-764459
	BMS-764459 is a potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1).
T23067	NGD 98-2 hydrochloride	Others	Others
	corticotropin-releasing factor receptor 1 (CRF1) antagonist
T25864	NGD9002 NGD-9002,NGD 9002
	NGD9002 is a novel generation, topology 2 selective corticotropin releasing factor-1 (CRF-1) receptor antagonist agent.
T71294	BMS-763534
	BMS-763534 is a potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1).
T69248	ONO-2333
	ONO-2333 is a corticotropin-releasing factor receptor antagonist, for the treatment of depression and/or anxiety disorders
T69374	NGD 98-2
	NGD 98-2 is a new generation, topology 2 selective orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
T38228	R 121919 hydrochloride
	High affinity corticotropin releasing factor receptor1 (CRF1) antagonist (Ki = 3.5 nM). Reduces stress-induced elevations of plasma ACTH. Anxiolytic and antidepressant in vivo. Orally bioavailable. Chen and Grigoriadis (2005) NBI 30775 (R121919), an orally active antagonist of the corticotropin-releasing factor (CRF) type-1 receptor for the treatment of anxiety and depression. Drug Dev.Res. 65 216 \|Jutkiewicz et al (2005) The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919...
TP1860	Urocortin II, human
	Human urocortin (hUcn) II is a new member of the corticotropin-releasing-factor (CRF) family. It selectively binds to the CRF2 receptor.
TP2048	α-Helical CRF(9-41) α-helical CRF 9-41
	Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).
TP2095	Astressin 2B
	Potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively). Antagonizes CRF2-mediated inhibition of gastric emptying.
TP2121	Sauvagine
	Corticotropin-releasing factor (CRF) receptor agonist. Ki values are 9.4, 9.9, and 3.8 nM for inhibition of 125I-[D-Tyr1]astressin binding to hCRF-R1, rCRF-R2a and mCRF-R2b respectively.
TP2125	Stressin I
	Potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.
T26855	BMS-665053 BMS665053
	BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM). In addi
TP2091	Antisauvagine-30
	Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells
TP1557	Urocortin II, human TFA
	Human urocortin (hUcn) II is a new member of the corticotropin-releasing-factor (CRF) family. It selectively binds to the CRF2 receptor. Human urocortin II exhibits mild motor-suppressive effects and delayed anxiolytic-like effects，suggesting a time-depen
T76492	(Tyr0)-Urocortin, rat
	(Tyr0)-Urocortin, rat 是针对促肾上腺皮质激素释放因子受体1型(CRF-R1)和2型(CRF-R2)的高亲和力激动剂，其抑制结合常数(Ki)为1-2 nM。
T35814	Urocortin III (human) (trifluoroacetate salt)
	Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III , mouse urocortin II , human urocortin , and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively)....
T76127	Urocortin II, mouse
	Urocortin II, mouse 是一种选择性的 2 型促肾上腺皮质激素释放因子 (CRF2) 受体内源性多肽激动剂，对CRFR2和CRFR1的Ki 值分别为 0.66 nM 和 ﹥100 nM。Urocortin II, mouse 通过以 cAMP/PKA 和 Ca2+/CaMKII 依赖性方式激活 CRF2 受体。Urocortin II, mouse 在中枢神经系统的离散区域表达，并激活参与内脏感觉信息处理和调节自主神经外流的中枢神经元。
T76180	Urocortin III (human)
	Urocortin III (human) 是一种促肾上腺皮质激素释放因子 (CRF) 相关肽。Urocortin III (human) 优先结合并激活CRF-R2，并且具有离散的中枢神经系统和外周分布。Urocortin III (human) 选择性结合 2 型 CRF 受体，mCRF2β、rCRF2α 和 hCRF1 的Ki 值分别为 13.5、21.7 和 >100 nM。Urocortin III (human) 介导Insulin(human) 分泌的生长抑素依赖性负反馈控制。
T83674	K 41498 TFA
	K 41498 是一种针对皮质酮释放因子受体2α（CRF2α）和CRF2β的肽拮抗剂，其在表达人类受体的HEK293细胞中的Ki值分别为0.66和0.62 nM。它对CRF2α和CRF2β具有选择性，与CRF1相比（在表达人类受体的HEK293细胞中Ki值为425 nM）。K 41498 (1.84 µg/动物, 静脉注射) 能够阻止大鼠由于尿催肾上腺皮质激素引发的低血压。通过脊髓内给药，K 41498 (0.075-0.5 µmol/动物) 能降低完全弗氏佐剂引起的大鼠模型中机械性爪撤回阈值。

化合物

Cat.No: T4329

Synonym: CP-316311

Target: CRFR

Cat.No: T12492

Synonym: CXB-722,匹伐加宾

Target: GABA Receptor

Cat.No: T7361

Synonym: NBI77860,3-(4-甲氧基-2-甲基苯基)-2,5-二甲基-N-[(1S)-1-(3-甲基-1,2,4-恶二唑-5-基)丙基]吡唑并[1,5-A]嘧啶-7-胺,GSK561679

Target: CRFR

Urocortin, human

Cat.No: TP1021

Synonym: Urocortin (human),Human urocortin,Human urocortin 1,Human urocortin I

Target: CRFR

Cat.No: T31095

Synonym: SSR125543,SSR 125543,SSR-125543,SSR125543A,SSR 125543A,SSR-125543A

Target: CRFR

Cat.No: T16475

Synonym: BMS-562086

Target: CRFR

Astressin acetate

Cat.No: TP1448L

Synonym: Astressin acetate (170809-51-5 Free base)

Target: CRFR

Cat.No: T12276

Target: Others

Cat.No: T27227

Synonym: E 2508,E-2508

Cat.No: T15214

Synonym: GW876008

Target: Others

Cat.No: T26856

NGD 98-2 hydrochloride

Cat.No: T23067

Target: Others

Cat.No: T25864

Synonym: NGD-9002,NGD 9002

Cat.No: T71294

Cat.No: T69248

Cat.No: T69374

R 121919 hydrochloride

Cat.No: T38228

Urocortin II, human

Cat.No: TP1860

α-Helical CRF(9-41)

Cat.No: TP2048

Synonym: α-helical CRF 9-41

Cat.No: TP2095

Cat.No: TP2121

Cat.No: TP2125

Cat.No: T26855

Synonym: BMS665053

Antisauvagine-30

Cat.No: TP2091

Urocortin II, human TFA

Cat.No: TP1557

(Tyr0)-Urocortin, rat

Cat.No: T76492

Urocortin III (human) (trifluoroacetate salt)

Cat.No: T35814

Urocortin II, mouse

Cat.No: T76127

Urocortin III (human)

Cat.No: T76180

Cat.No: T83674

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