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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12401	Pemigatinib INCB054828	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Pemigatinib (INCB054828) 是一种口服具有活力的，选择性的 FGFR 抑制剂，能够作用于 FGFR1 (IC50:0.4 nM)，FGFR2 (IC50:0.5 nM)，FGFR3 (IC50:1.2 nM)，FGFR4 (IC50:30 nM)，有用于胆管癌的潜力。
T72932	Triphen diol
	Triphen diol 是一种苯酚二醇衍生物，对胰腺癌和胆管癌具有优异的抗癌活性，可以通过caspase 介导的和caspase 不依赖的两种机制诱导胰腺细胞凋亡(apoptosis)。
T70143	Derazantinib dihydrochloride
	Derazantinib is a multi-kinase inhibitor with pan-FGFR activity which has shown preliminary therapeutic activity against FGFR2 fusion-positive intrahepatic cholangiocarcinoma (iCCA). Derazantinib dihydrochloride is a salt of Derazantinib.
T71004	Infigratinib monohydrate
	Infigratinib monohydrate, also known as, BGJ398 monohydrate or NVP-BGJ398 monohydrate, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. pan FGFR kinase inhibitor BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Infigr...
T71002	Infigratinib acetate
	Infigratinib acetate, also known as, BGJ398 acetate or NVP-BGJ398 acetate, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. pan FGFR kinase inhibitor BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Infigratinib aceta...
T71003	Infigratinib mesylate
	Infigratinib mesylate, also known as, BGJ398 mesylate or NVP-BGJ398 mesylate, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. pan FGFR kinase inhibitor BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Infigratinib me...

化合物

Pemigatinib

Cat.No: T12401

Synonym: INCB054828

Derazantinib dihydrochloride

Cat.No: T70143

Synonym:

Target:

Infigratinib monohydrate

Infigratinib mesylate

Cat.No: T71003

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T3878	Raddeanin A NSC382873,竹节香附素A,Anemodeanin A,Raddeanin R3	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Raddeanin A (NSC-382873) 是竹节香附中的一种天然三萜皂苷，可抑制组蛋白去乙酰化酶，具有很强的抗血管生成能力和抗肿瘤活性。
TN4591	Murralongin	Others	Others
	Murralongin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100.
TN4564	Micromelin	Others	Others
	Micromelin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100.
TN4570	Minumicrolin	Others	Others
	Minumicrolin is a plant growth inhibitor against the 2nd leaf sheath elongation of rice seedlings. Murrangatin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100, it might be valuable anti-tumor-promoting agents. Minumicrolin shows mild butyrylcholinesterase inhibition activity.
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,