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Cat. No.	Product Name	Target	Signaling Pathways
T7763	Thalidomide-4-OH Cereblon ligand 2,E3 ligase Ligand 2	Ligand for E3 Ligase	PROTAC
	Thalidomide-4-OH (E3 ligase Ligand 2) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T7757	Cereblon Ligand -Linker Conjugates 2 TFA
	Cereblon Ligand -Linker Conjugates 2 TFA 是一种 E3 连接酶配体- linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 linker。
T17918	Thalidomide-O-amido-PEG2-C2-NH2 TFA E3 Ligase Ligand-Linker Conjugates 24 TFA,Cereblon Ligand-Linker Conjugates 10 TFA	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	Thalidomide-O-amido-PEG2-C2-NH2 TFA (E3 Ligase Ligand-Linker Conjugates 24 TFA) 包含基于 Thalidomide 的 cereblon 配体和 2 个单元的 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T7756	Pomalidomide-PEG4-Ph-NH2	Ligand for E3 Ligase	PROTAC
	Pomalidomide-PEG4-Ph-NH2 是一种合成的 E3 连接酶配体- linker 偶联物，结合了基于 Pomalidomide 的 cereblon 配体和 4 单元 PEG linker。
T7761	Pomalidomide-C2-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase	PROTAC
	Pomalidomide-C2-NH2 hydrochloride 包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker，是合成的 E3 连接酶配体-linker 偶联物。
T18555	Pomalidomide-PEG2-Tos Cereblon Ligand-Linker Conjugates 16,E3 ligase Ligand-Linker Conjugates 52	Others	Others
	Pomalidomide-PEG2-Tos is a compound that consists of an E3 ligase ligand-linker conjugate. It is composed of a cereblon ligand conjugated to a two-unit PEG linker[1].
T17819	Thalidomide-O-amido-C8-NH2 E3 Ligase Ligand-Linker Conjugates 20,Cereblon Ligand-Linker Conjugates 2	Others	Others
	Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker. This compound is useful in the synthesis of PROTACs, as per reference [1].
T17903	Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH E3 ligase Ligand-Linker Conjugates 49,Cereblon Ligand-Linker Conjugates 14	Others	Others
	Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized compound, designed as an E3 ligase ligand-linker conjugate, integrating the cereblon ligand derived from Pomalidomide and a linker employed in PROTAC technology. This compound serves to facilitate targeted protein degradation through the modulation of E3 ligase activity, enabling the selective elimination of specific proteins of interest.
T17875	Pomalidomide-C2-NH2 Cereblon Ligand-Linker Conjugates 15,4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	Others; Ligand for E3 Ligase	Others; PROTAC
	Pomalidomide-C2-NH2 (4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) 包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物，。
T17917	Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 E3 Ligase Ligand-Linker Conjugates 23 TFA,Cereblon Ligand-Linker Conjugates 12 TFA	Others	Others
	Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized conjugate compound known as an E3 ligase ligand-linker. It incorporates a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology applications.
T40094	Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2,Cereblon Ligand-Linker Conjugates 12,E3LigaseLigand-LinkerConjugates23
	Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly utilized in PROTAC technology. This compound acts as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.
T39375	Thalidomide-O-amido-PEG2-C2-NH2 Cereblon Ligand-Linker Conjugates 10,E3LigaseLigand-LinkerConjugates24,Thalidomide-O-amido-PEG2-C2-NH2
	Thalidomide-O-amido-PEG2-C2-NH2, which combines an E3 ligase ligand with a linker, serves as an immunomodulator for cancer treatment.
T40025	Pomalidomide-PEG2-CO2H Pomalidomide 4'-PEG2-acid,Pomalidomide-PEG2-C2-acid	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Pomalidomide-PEG2-CO2H 是一种合成的 E3 连接酶配体-接头偶联物，包含基于 Pomalidomide 的 cereblon 配体和 2 单元 PEG 接头。
T40024	Pomalidomide-PEG1-CO2H Pomalidomide-PEG1-C2-COOH	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Pomalidomide-PEG1-CO2H 是一种合成的 E3 连接酶配体-接头偶联物，包含基于 Pomalidomide 的 cereblon 配体和 2 单元 PEG 接头。
T40016	Thalidomide-NH-CH2-COOH 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine	Ligand for E3 Ligase	PROTAC
	Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T9291	Thalidomide-5-OH 4 - 羟基沙利度胺,2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) 是基于 Thalidomide 的的cereblon 配体，可用于募集CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T9401	Thalidomide-NH-PEG1-NH2 hydrochloride 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 的合成。
T9381	Thalidomide 5-fluoride 2-(2,6-二氧代 - 哌啶-3-基)-5-氟 - 异吲哚-1,3-二酮,H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-	Ligand for E3 Ligase	PROTAC
	Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) 是一种基于沙利度胺的 Cereblon 配体，通过 linker 与 IRAK4 蛋白配体结合形成 PROTACIRAK4 degrader-1。
T40026	Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid	Others	Others
	Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid)可用于后续化学的带有烷基接头和末端酸的 Cereblon 配体。
T9382	Thalidomide-NH-C2-PEG3-OH H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是 E3 连接酶配体-linker 偶联物，可用于合成 PROTAC BCL-XL 降解剂 XZ739。
T18812	Thalidomide-PEG2-C2-NH2 TFA Thalidomide-NH-PEG2-C2-NH2 TFA	Others	Others
	Thalidomide-O-amido-PEG3-C2-NH2 TFA, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon ligand based on Thalidomide and a 2-unit PEG linker for use in PROTAC technology[1].
T17906	Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc E3 Ligase Ligand-Linker Conjugates 53,Cereblon Ligand-Linker Conjugates 20	Others	Others
	Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a novel synthesized conjugate compound functioning as an E3 ligase ligand-linker in PROTAC technology. This compound incorporates a Pomalidomide-derived cereblon ligand, which binds selectively to the E3 ligase cereblon, and a 2-unit PEG linker, which provides stability and flexibility to the conjugate.
T39803	Pomalidomide-PEG2-azide Pomalidomide-PEG2-azide
	Pomalidomide-PEG2-azide is a synthetic conjugate consisting of a cereblon ligand derived from Pomalidomide and a 2-unit PEG linker, designed for use in PROTAC technology as a ligand-linker conjugate of E3 ligase.
T18067	Lenalidomide-PEG1-azide	Others	Others
	Lenalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate that incorporates the cereblon ligand based on Lenalidomide and a linker. It is designed for use in the development of PROTAC BRD4 Degrader-2[1].
T18813	Thalidomide-PEG2-C2-NH2 Thalidomide-NH-PEG2-C2-NH2	Others	Others
	Thalidomide-O-amido-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].
T18826	Thalidomide-O-PEG2-propargyl E3 ligase Ligand-Linker Conjugates 32	Others	Others
	Thalidomide-O-PEG2-propargyl (E3 Ligase Ligand-Linker Conjugates 32) is a chemical compound that has been synthesized as a conjugate of an E3 ligase ligand and a linker. It incorporates the cereblon ligand based on Thalidomide, along with a 2-unit PEG linker. This compound is specifically designed for use in PROTAC technology, which utilizes ligand-induced protein degradation [1].
T18641	SirReal1-O-propargyl PROTAC Sirt2-binding moiety 1	Others	Others
	SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2[1].
T80646	Thalidomide-NH-(CH2)2-NH2 TFA
	Thalidomide-NH-(CH2)2-NH2 TFA 是一种烷基修饰的 Thalidomide，用作 Cereblon 配体以招募 CRBN 蛋白。它是在以 CRBN 为基础设计的 PROTAC 分子合成中的关键中间体，并用于合成针对 SHP2 蛋白的 PROTAC 小分子。
T73909	Abemaciclib metabolite M18 LSN3106729	Ligands for Target Protein for PROTAC	PROTAC
	Abemaciclibmetabolite M18 (LSN3106729) 是一种CDK抑制剂，具有抗肿瘤活性。作为Abemaciclib的代谢物，Abemaciclibmetabolite M18 能与CRBN配体结合，用于设计PROTAC CDK4/6降解剂。
T81942	Lenalidomide sodium CC-5013 sodium
	Lenalidomide (sodium)是Thalidomide的衍生物，这种口服活性的免疫调节剂通过分子胶模式作用。作为泛素E3连接酶cereblon(CRBN)的配体，Lenalidomide (sodium)通过CRBN-CRL4泛素连接酶复合体，针对淋巴转录因子IKZF1和IKZF3进行选择性泛素化和降解。此外，Lenalidomide (sodium)有效抑制成熟B细胞淋巴瘤的增长，如多发性骨髓瘤，并能促使T细胞分泌白细胞介素-2(IL-2)。
T21763	Lenalidomide hydrochloride
	Lenalidomide hydrochloride (CC-5013 hydrochloride) 是 Thalidomide 的衍生物，也是一种具有口服活性免疫调节剂，以分子胶的方式作用。Lenalidomide hydrochloride (CC-5013 hydrochloride) 是一种泛素 E3 连接酶 cereblon (CRBN) 的配体，通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。Lenalidomide hydrochloride (CC-5013 hydrochloride) 特异性抑制成熟 B 细胞淋巴瘤 (包括多发性骨髓瘤) 的生长，并诱导 T 细胞释放白细胞介素-2 (IL-2)。
T83889	C-02
	C-02是一种由巨噬细胞抑制剂Lonidamine和Cereblon配体Thalidomide组成的蛋白酶体靶向嵌合体（PROTAC）。在20 µM浓度下使用时，可诱导786-O和PANC-1细胞中的Hexokinase 2降解。C-02对786-O、4T1、PANC-1、HGC-27和MCF-7癌细胞具有细胞毒性（IC50分别为34.07、5.08、31.53、6.11和21.65 µM）。同时，20 µM浓度下减少4T1细胞的细胞外酸化率（ECAR）和氧气消耗率（OCR），表明其抑制糖酵解和引起线粒体损伤。在体内，C-02（50 mg/kg）能减少4T1小鼠乳腺癌模型的肿瘤体积，并诱导肿瘤内细胞因子积累和细胞焦亡。

化合物

Thalidomide-4-OH

Cat.No: T7763

Synonym: Cereblon ligand 2,E3 ligase Ligand 2

Target: Ligand for E3 Ligase

Cereblon Ligand -Linker Conjugates 2 TFA

Cat.No: T7757

Thalidomide-O-amido-PEG2-C2-NH2 TFA

Cat.No: T17918

Synonym: E3 Ligase Ligand-Linker Conjugates 24 TFA,Cereblon Ligand-Linker Conjugates 10 TFA

Target: Others, E3 Ligase Ligand-Linker Conjugate

Pomalidomide-PEG4-Ph-NH2

Cat.No: T7756

Target: Ligand for E3 Ligase

Pomalidomide-C2-NH2 hydrochloride

Cat.No: T7761

Target: E3 Ligase Ligand-Linker Conjugate, Ligand for E3 Ligase

Pomalidomide-PEG2-Tos

Cat.No: T18555

Synonym: Cereblon Ligand-Linker Conjugates 16,E3 ligase Ligand-Linker Conjugates 52

Target: Others

Thalidomide-O-amido-C8-NH2

Cat.No: T17819

Synonym: E3 Ligase Ligand-Linker Conjugates 20,Cereblon Ligand-Linker Conjugates 2

Target: Others

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH

Cat.No: T17903

Synonym: E3 ligase Ligand-Linker Conjugates 49,Cereblon Ligand-Linker Conjugates 14

Target: Others

Pomalidomide-C2-NH2

Cat.No: T17875

Synonym: Cereblon Ligand-Linker Conjugates 15,4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Target: Others, Ligand for E3 Ligase

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2

Cat.No: T17917

Synonym: E3 Ligase Ligand-Linker Conjugates 23 TFA,Cereblon Ligand-Linker Conjugates 12 TFA

Target: Others

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2

Cat.No: T40094

Synonym: Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2,Cereblon Ligand-Linker Conjugates 12,E3LigaseLigand-LinkerConjugates23

Thalidomide-O-amido-PEG2-C2-NH2

Cat.No: T39375

Synonym: Cereblon Ligand-Linker Conjugates 10,E3LigaseLigand-LinkerConjugates24,Thalidomide-O-amido-PEG2-C2-NH2

Pomalidomide-PEG2-CO2H

Cat.No: T40025

Synonym: Pomalidomide 4'-PEG2-acid,Pomalidomide-PEG2-C2-acid

Target: E3 Ligase Ligand-Linker Conjugate

Pomalidomide-PEG1-CO2H

Cat.No: T40024

Synonym: Pomalidomide-PEG1-C2-COOH

Target: E3 Ligase Ligand-Linker Conjugate

Thalidomide-NH-CH2-COOH

Cat.No: T40016

Synonym: 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine

Target: Ligand for E3 Ligase

Thalidomide-5-OH

Cat.No: T9291

Synonym: 4 - 羟基沙利度胺,2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

Target: Others, Ligand for E3 Ligase

Thalidomide-NH-PEG1-NH2 hydrochloride

Cat.No: T9401

Synonym: 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Target: E3 Ligase Ligand-Linker Conjugate

Thalidomide 5-fluoride

Cat.No: T9381

Synonym: 2-(2,6-二氧代 - 哌啶-3-基)-5-氟 - 异吲哚-1,3-二酮,H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-

Target: Ligand for E3 Ligase

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-

Cat.No: T40026

Synonym: 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid

Target: Others

Thalidomide-NH-C2-PEG3-OH

Cat.No: T9382

Synonym: H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-

Target: E3 Ligase Ligand-Linker Conjugate

Thalidomide-PEG2-C2-NH2 TFA

Cat.No: T18812

Synonym: Thalidomide-NH-PEG2-C2-NH2 TFA

Target: Others

Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc

Cat.No: T17906

Synonym: E3 Ligase Ligand-Linker Conjugates 53,Cereblon Ligand-Linker Conjugates 20

Target: Others

Pomalidomide-PEG2-azide

Cat.No: T39803

Synonym: Pomalidomide-PEG2-azide

Lenalidomide-PEG1-azide

Cat.No: T18067

Target: Others

Thalidomide-PEG2-C2-NH2

Cat.No: T18813

Synonym: Thalidomide-NH-PEG2-C2-NH2

Target: Others

Thalidomide-O-PEG2-propargyl

Cat.No: T18826

Synonym: E3 ligase Ligand-Linker Conjugates 32

Target: Others

SirReal1-O-propargyl

Cat.No: T18641

Synonym: PROTAC Sirt2-binding moiety 1

Target: Others

Thalidomide-NH-(CH2)2-NH2 TFA

Cat.No: T80646

Abemaciclib metabolite M18

Cat.No: T73909

Synonym: LSN3106729

Target: Ligands for Target Protein for PROTAC

Lenalidomide sodium

Cat.No: T81942

Synonym: CC-5013 sodium

Lenalidomide hydrochloride

Cat.No: T21763

Cat.No: T83889

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