首页工具

登录

搜索结果

Search Results for " cxcr3 "

17

抑制剂 & 化合物

1

天然产物

7

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T36982	CXCR3 Antagonist 6c
	CXCR3 antagonist 6c is an antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3).1It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 11 (CXCL11) in HEK293 cells expressing the human receptor (IC50= 0.06 μM). It is selective for CXCR3 over a panel of 14 human G protein-coupled receptors at 10 μM. CXCR3 antagonist 6c inhibits CXCR3-mediated migration of isolated human T cells (IC50= ~100 nM). 1.Cole, A.G., Stroke, I.L., Brescia, M.-R., et al.Identification and initial eva...
T10297L	AMG 487	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	AMG 487 是可口服的选择性趋化因子受体3拮抗剂，对 I-IP-10、I-ITAC 和 MIG 的 IC50 值分别为 8、15 和 36nM。
T26035	rac-NBI-74330 rac NBI 74330,racNBI74330	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	rac-NBI-74330是一种有效的、选择性的 CXCR3拮抗剂。
T35085	VUF-11222 VUF 11222
	VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).
T7499	TAK-779 Takeda 779	HIV Protease; CXCR; CCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	TAK-779 (Takeda 779) 是一种非肽类CCR5和CXCR3 拮抗剂，对CCR5的Ki 值为 1.1 nM，并选择性抑制R5 HIV-1。
T3360	ZK 756326 ZK756326 2HCl	CCR	Immunology/Inflammation; Microbiology/Virology
	ZK 756326 是一种选择性的非肽 CCR8 趋化因子受体激动剂（IC50：1.8 μM，在人体内；2.6 μM，在小鼠体内）。对 CCR4/5 和 CXCR3/4 没有活性，比其他 26 种 GPCR 的选择性高 28 倍（对 α2A 和 5-HT 受体的选择性较低）。诱导趋化性并抑制 Env 介导的 (HIV) 细胞-细胞融合。
T16863	SCH 546738	Others	Others
	SCH 546738 is an effective and non-competitive CXCR3 antagonist. SCH 546738 bindings to the human CXCR3 receptor is determined (Ki: 0.4 nM) in multiple experiments.
T12567	PS372424	Others	Others
	PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.
T70616	ACT-672125
	ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner.
T70411	PS372424 HCl
	PS372424 is a specific agonist of human CXCR3. It has been shown to induce phosphorylation of ERK and block CXCL11 induced migration of CD45+ cells to air pouches generated on humanized mice.
T24949	VUF10132 VUF-10132,VUF 10132
	VUF10132 is a full inverse CXCR3 N3.35A agonist.
T29147	VUF5834 VUF-5834,VUF 5834
	VUF5834 is a full inverse agonist of CXCR3 N3.35A.
T22477	(±)-AMG 487	Others	Others
	AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36 nM, respectively).
T10297	AMG 487 (S-enantiomer)	Others	Others
	AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.
T63761	ACT-660602
	ACT-660602 是口服具有活力的趋化因子受体 CXCR3 拮抗剂 (IC50: 204 nM)。ACT-660602 能够抑制 T 细胞迁移，并在体内急性肺损伤模型中显示出显著作用。ACT-660602 能够用于研究自身免疫性疾病。
T23656	VUF11211 VUF-11211,VUF 11211
	VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.
T73148	ACT-777991
	ACT-777991为一种选择性、口服生效的CXCR3拮抗剂，于动物模型中展现出微粒体及肝细胞稳定性，能抑制活化T细胞向CXCL11迁移。

化合物

CXCR3 Antagonist 6c

Cat.No: T36982

Cat.No: T10297L

Target: CXCR

Cat.No: T26035

Synonym: rac NBI 74330,racNBI74330

Target: CXCR

Cat.No: T35085

Synonym: VUF 11222

Cat.No: T7499

Synonym: Takeda 779

Target: HIV Protease, CXCR, CCR

Cat.No: T3360

Synonym: ZK756326 2HCl

Target: CCR

Cat.No: T16863

Target: Others

Cat.No: T12567

Target: Others

Cat.No: T70616

Cat.No: T70411

Cat.No: T24949

Synonym: VUF-10132,VUF 10132

Cat.No: T29147

Synonym: VUF-5834,VUF 5834

Cat.No: T22477

Target: Others

AMG 487 (S-enantiomer)

Cat.No: T10297

Target: Others

Cat.No: T63761

Cat.No: T23656

Synonym: VUF-11211,VUF 11211

Cat.No: T73148

Cat. No.	Product Name	Target	Signaling Pathways
T3765	L-asarinin 細辛素,(-)-Episesamin	Others	Others
	L-asarinin ((-)-Episesamin) 降低外周血 IL-12 浓度并抑制 CXCR3 和 TLR4 的表达，这意味着 Asarinin 可能在 TLR4 通路中发挥作用，并延长同种异体心脏的存活时间。

天然产物

Cat.No: T3765

Synonym: 細辛素,(-)-Episesamin

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01162	CXCR3 Protein, Human, Recombinant (GST & His) IP-10 receptor,CXCR3,CXC-R3,GPR9,...	Human	E. coli
	CXCR3 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
TMPH-02612	CXCR3 Protein, Mouse, Recombinant (His & KSI) CXC-R3,CKR-L2,CXCR3,CD183	Mouse	E. coli
	Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21.
TMPY-03274	CXCL11 Protein, Human, Recombinant SCYB9B,I-TAC,chemokine (C-X-C motif) ligand 11,H174,SCYB11,I...	Human	E. coli
	I-TAC, also known as CXCL11, is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. The I-TAC chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC ...
TMPJ-00008	CXCL10 Protein, Human, Recombinant (hFc & His) INP10,10 kDa Interferon Gamma-Induced Protein,C-X-C Motif Ch...	Human	HEK293 Cells
	Human C-X-C Motif Chemokine Ligand 10 (CXCL10) is a non-ELR chemokine secreted by various cell types, such as monocytes, endothelial cells and fibroblasts, in response to IFN-γ. CXCL10 functions via chemokine receptor CXCR3. CXCL10 has been attributed to several roles, such as chemoattraction for activated T-lymphocytes, inhibition of angiogenesis, and antitumor activity.
TMPJ-00884	CXCL9 Protein, Mouse, Recombinant (His) Protein m119,C-X-C motif chemokine 9,γ-interferon-induced mo...	Mouse	HEK293 Cells
	Chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), is a small cytokine belonging to the CXC chemokine family. CXCL9 functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. It together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour e...
TMPJ-01084	CXCL9 Protein, Human, Recombinant (His) Monokine Induced by Interferon-γ,Gamma-Interferon-Induced Mo...	Human	HEK293 Cells
	Chemokine (C-X-C Motif) Ligand 9 (CXCL9) belongs to the intercrine alpha (chemokine CXC) family. It is secreted by interferon stimulated monocytes, macrophages and endothelial cells, which elicits chemotactic functions by interacting with the chemokine receptor CXCR3. CXCL9 acts as a Th1 (type 1 helper T) cell chemoattractant and plays a role in the growth, activation and movement of cells associated with immune and inflammatory responses, and in tumour growth inhibition. It is closely related t...
TMPJ-00012	CXCL4 Protein, Human, Recombinant (His) SCYB4,PF4,Iroplact,Platelet Factor 4,PF-4,Oncostatin-A,CXCL4...	Human	HEK293 Cells
	Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokin...

重组蛋白

CXCR3 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01162

Species: Human

Expression System: E. coli

CXCR3 Protein, Mouse, Recombinant (His & KSI)

Cat.No: TMPH-02612

Species: Mouse

Expression System: E. coli

CXCL11 Protein, Human, Recombinant

Cat.No: TMPY-03274

Species: Human

Expression System: E. coli

CXCL10 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00008

Species: Human

Expression System: HEK293 Cells

CXCL9 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00884

Species: Mouse

Expression System: HEK293 Cells

CXCL9 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01084

Species: Human

Expression System: HEK293 Cells

CXCL4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00012

Species: Human

Expression System: HEK293 Cells

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼