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Cat. No.	Product Name	Target	Signaling Pathways
T10889	CRTh2 antagonist 2	GPR	Endocrinology/Hormones; GPCR/G Protein
	CRTh2 antagonist 2 是一种有效的选择性 CRTH2 抑制剂，对 CRTH2 的 IC50 值为 ≤10 nM。CRTh2 antagonist 2 可用于雄激素性脱发的研究。
T10084	CRTh2 antagonist 1	GPR	Endocrinology/Hormones; GPCR/G Protein
	CRTh2 antagonist 1 是 CRTh2 拮抗剂，IC50 值为 89 nM。
T10890	CRTh2 antagonist 3	Others	Others
	CRTh2 antagonist 3 is a powerful chemokine receptor homologous molecule expressed on Th2 cell (CRTh2) antagonists. CRTh2 antagonist 3 enhanced the activity of PDK1 on short peptide substrates with EC50 of 2 μM and Kd of 8.4 μM. CRTh2 antagonist 3 has the
T10891	CRTH2-IN-1 Ramatroban analog	P450	Metabolism
	CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
T17232	Vidupiprant AMG 853	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Vidupiprant (AMG 853) 是一种有效的 CRTH2 和前列腺素 D 受体双重拮抗剂，在人源血浆中的 IC50 分别为 8 nM 和 35 nM。 Vidupiprant 可用于治疗哮喘的研究。
T14565	BI-671800 AP-761,Cmpd A	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	BI-671800 (AP-761) 是高特异性的前列腺素 D2 受体拮抗剂，对哮喘有研究潜力，对人和小鼠 CRTH2 转染细胞中 PGD2 结合 CRTH2 的 IC50值分别为 4.5 和 3.7 nM。
T3965	Fevipiprant QAW039,NVP-QAW039,非维匹仑	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	Fevipiprant (NVP-QAW039) 是一种选择性、强效、可逆的竞争性 CRTh2 拮抗剂，KD 值为1.1 nM，IC50为0.44 nM，能够引发人体嗜酸性粒细胞的形状变化。
T3520	Setipiprant KYTH-105,塞替匹仑,ACT-129968	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	Setipiprant (ACT-129968) 是一种口服的选择性 CRTH2 拮抗剂，IC50为6.0 nM。
T10691	CAY10595	GPR	Endocrinology/Hormones; GPCR/G Protein
	CAY10595 是 CRTh2 (DP2) 受体的拮抗剂，Ki 为 10 nM。
T7359	CAY10471 Racemate TM30089 Racemate,3-[[(4-氟苯基)磺酰基]甲基氨基]-1,2,3,4-四氢-9H-咔唑-9-乙酸	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	CAY10471 Racemate (TM30089 Racemate) 是一种高选择性的 CRTH2/DP 2 受体拮抗剂，对 hCRTH2 的Ki 值为 0.6 nM，对其选择性远高于人血栓素 A2 受体 TP 或 PGD2 受体 DP。它对大小鼠的同源 CRTH2 也具有拮抗作用。
T6399	AZD1981	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	AZD1981 是一种有效且特异性的 CRTh2 (DP2) 受体拮抗剂，IC50为 4 nM，用于研究哮喘、绝经后、药代动力学、哮喘患者和药物相互作用等治疗和基础科学的试验。
T77601	(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid	GPR	Endocrinology/Hormones; GPCR/G Protein
	(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid是一种前列腺素类 CRTH2拮抗剂，其IC50< 10 μM，可用于研究鼻炎、慢性阻塞性肺疾病、类风湿性关节炎、湿疹和结膜炎。
T2396	Ramatroban BAY u3405,雷马曲班	GPR; Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism
	Ramatroban (BAY u3405) 是一种血栓素 A(2) (TxA(2)) 拮抗剂，IC50为 14 nM。它还通过抑制PGD2结合从而拮抗CRTH2，IC50为113 nM。它用于治疗过敏性鼻炎，可用于治疗哮喘的研究。
T3306	PF-04418948 PF 04418948,PF04418948	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	PF-04418948 是一种可口服的，选择性的前列腺素EP2受体拮抗剂，IC50为16 nM。
T28927	TASP0412098 TASP 0412098,TASP-0412098
	TASP0412098 is a potent, selective CRTH2 antagonist with oral activity.
TQ0051	MK-7246	GPR	Endocrinology/Hormones; GPCR/G Protein
	MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).
T14211	AMG-009	Others	Others
	AMG-009 is a prostaglandin D2 antagonist. For CRTH2 and DP receptors, the IC50s are 3 nM and 12 nM, respectively.
T16097	MK-8318	Others	Others
	MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM).
T37328	Prostaglandin H1 Prostaglandin H1
	Prostaglandin H1 是 DGLA 的环氧化酶代谢物，也是一种 CRTh2 激动剂以及 1 系列抗炎前列腺素的前体物质。Prostaglandin H1 可用于炎症的研究。
T15828	L 888607	Others	Others
	L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM).
T28925	TASP0376377 TASP-0376377,TASP 0376377
	TASP0376377 is a potent antagonist of CRTH2.
T27799	LAS191859 LAS-191859,LAS 191859
	LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 7.6, 9.58, 14 and 15.5nM for recombinant guinea pig, human, rat and mouse CRTH2/DP2 receptors, respectively. LAS191859 has a residence time half-life of 21h at CRTh2 that translates into a long-lasti
T37264	15(R)-15-methyl Prostaglandin D2 15(R)15methyl PGD2	GPR	Endocrinology/Hormones; GPCR/G Protein
	15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) 是一种 PGD2 合成类似物，也是一种具有选择性和强效性的 CRTH2/DP2 受体激动剂，可调节嗜酸性粒细胞 CD11b 表达、肌动蛋白聚合和趋化。
T12067	MK-7246 S enantiomer	Others	Others
	MK-7246 S enantiomer is a potent and selective CRTH2 antagonist.
T28221	NVP-QAV-680 NVP-QAV680,QAV690 free acid,NVP,QAV-690 free acid,NVPQAV680,QAV 690 free acid
	NVP-QAV-680 is a potent and selective antagonist of CRTh2 receptor. NVP-QAV-680 has nM functional potency for inhibition of CRTh2 driven human eosinophil and Th2 lymphocyte activation in vitro.
T38365	CAY10597
	The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the...
T71245	ARRY-502
	ARRY-502 is a CRTH2 antagonist. Regulation of cytokine activity is important in molecularly targeted therapies for asthma.
T36545	Prostaglandin D2 methyl ester Prostaglandin D2 methyl ester
	Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypotension, and is an inhibitor of platelet aggregation. Prostaglandin D2 methyl ester (PGD2 methyl ester) is a more lipid-soluble, cell-permeable prodrug form of PGD2. It binds to the human and mouse PGD2 receptors (DP1 and CRTH2/DP2) with 5-10 fold lower affinity than PGD2.

化合物

CRTh2 antagonist 2

Cat.No: T10889

Target: GPR

CRTh2 antagonist 1

Cat.No: T10084

Target: GPR

CRTh2 antagonist 3

Cat.No: T10890

Target: Others

Cat.No: T10891

Synonym: Ramatroban analog

Target: P450

Cat.No: T17232

Synonym: AMG 853

Target: Prostaglandin Receptor

Cat.No: T14565

Synonym: AP-761,Cmpd A

Target: GPR, Prostaglandin Receptor

Cat.No: T3965

Synonym: QAW039,NVP-QAW039,非维匹仑

Target: GPR, Prostaglandin Receptor

Cat.No: T3520

Synonym: KYTH-105,塞替匹仑,ACT-129968

Target: GPR, Prostaglandin Receptor

Cat.No: T10691

Target: GPR

CAY10471 Racemate

Cat.No: T7359

Synonym: TM30089 Racemate,3-[[(4-氟苯基)磺酰基]甲基氨基]-1,2,3,4-四氢-9H-咔唑-9-乙酸

Target: GPR, Prostaglandin Receptor

Cat.No: T6399

Target: GPR, Prostaglandin Receptor

(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid

Cat.No: T77601

Target: GPR

Cat.No: T2396

Synonym: BAY u3405,雷马曲班

Target: GPR, Prostaglandin Receptor, PPAR

Cat.No: T3306

Synonym: PF 04418948,PF04418948

Target: Prostaglandin Receptor

Cat.No: T28927

Synonym: TASP 0412098,TASP-0412098

Cat.No: TQ0051

Target: GPR

Cat.No: T14211

Target: Others

Cat.No: T16097

Target: Others

Prostaglandin H1

Cat.No: T37328

Synonym: Prostaglandin H1

Cat.No: T15828

Target: Others

Cat.No: T28925

Synonym: TASP-0376377,TASP 0376377

Cat.No: T27799

Synonym: LAS-191859,LAS 191859

15(R)-15-methyl Prostaglandin D2

Cat.No: T37264

Synonym: 15(R)15methyl PGD2

Target: GPR

MK-7246 S enantiomer

Cat.No: T12067

Target: Others

Cat.No: T28221

Synonym: NVP-QAV680,QAV690 free acid,NVP,QAV-690 free acid,NVPQAV680,QAV 690 free acid

Cat.No: T38365

Cat.No: T71245

Prostaglandin D2 methyl ester

Cat.No: T36545

Synonym: Prostaglandin D2 methyl ester

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