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Search Results for " clax "

Targets Recommended: BCL Autophagy

20

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2119	Venetoclax GDC-0199,ABT 199,维奈妥拉,ABT-199,ABT199	BCL; Autophagy	Apoptosis; Autophagy
	Venetoclax (ABT-199) 是一种 Bcl-2 抑制剂 (Ki<0.01 nM)，具有高效性、选择性和口服活性。Venetoclax 与 Bcl-xL 和 Bcl-W 的亲和力降低了 3 个数量级（Kis=48/245 nM）。Venetoclax 可以诱导自噬和凋亡。
T2101	Navitoclax ABT-263	BCL	Apoptosis
	Navitoclax (ABT-263) 是一种 Bcl-2 抑制剂，可与 Bcl-xL、Bcl-2、Bcl-w 等蛋白结合 (Ki<1 nM)，具有有效性和口服活性。Navitoclax 具有抗肿瘤活性，可以诱导细胞凋亡。
T12186	Navitoclax-piperazine ABT-263-piperazine	BCL; Ligands for Target Protein for PROTAC	Apoptosis; PROTAC
	Navitoclax-piperazine (ABT-263-piperazine) 是一种特大型 B 细胞淋巴瘤(BCL-XL)抑制剂。它和 E3 泛素连接酶的 VHL 配体可用来合成 PROTAC DT2216。
T11944	Maritoclax Marinopyrrole A	BCL	Apoptosis
	Maritoclax (Marinopyrrole A) 是一种新型特异性 Mcl-1 抑制剂，IC50值为 10.1 μM，对 BCL-xl 的 IC50值 > 80 μM。
T10483	Lisaftoclax Bcl-2/Bcl-xl inhibitor 1,APG-2575	BCL	Apoptosis
	Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) 是一种双重 Bcl-2 和 Bcl-xl 抑制剂(IC50：2 nM 和 5.9 nM)，具有抗肿瘤活性。
T6650	Sabutoclax BI-97C1	BCL	Apoptosis
	Sabutoclax (BI-97C1) 是一种泛 Bcl-2 抑制剂，包括 Bcl-xL、Bcl-2、Mcl-1 和 Bfl-1，IC50 分别为 0.31 μM、0.32 μM、0.20 μM 和 0.62 μM。
T6275	Obatoclax Mesylate Obatoclax,GX15-070,奥巴克拉甲磺酸盐	BCL; Parasite; Autophagy	Apoptosis; Autophagy; Microbiology/Virology
	Obatoclax Mesylate (GX15-070) 是泛 BCL-2家族蛋白抑制剂，对 BCL-2 的 Ki 值为 220 nM。它是 BH3 模拟物，具有抗癌和广谱抗寄生虫活性。它诱导自噬依赖性细胞死亡，并靶向细胞周期蛋白 D1 进行蛋白酶体降解。
T39910	Desmorpholinyl Navitoclax-NH-Me Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me	BCL	Apoptosis
	Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2].
T14213	Tapotoclax AMG-176	BCL	Apoptosis
	AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).
T41278	Obatoclax
	Obatoclax (GX15-070) 是一种 BH3 模拟物，是泛BCL-2家族蛋白抑制剂，对 BCL-2 的Ki 值为 220 nM。Obatoclax 诱导依赖自噬 (autophagy)的细胞死亡，并靶向细胞周期蛋白 D1 进行蛋白酶体降解。Obatoclax 具有抗癌和广谱抗寄生虫 (antiparasitic) 活性。
T27600	Imlatoclax
	Imlatoclax has antineoplastic activity.
T36901	Pelcitoclax
	Pelcitoclax (APG-1252) is a powerful inhibitor of the Bcl-2 and Bcl-xl proteins, displaying significant antineoplastic and pro-apoptotic properties[1].
TMIH-0594	Venetoclax-d8
	Venetoclax-d8 是 Venetoclax 的氘代化合物。
T74637	Sonrotoclax
	Sonrotoclax为一种口服有效的Bcl2抑制剂，对多种淋巴瘤和白血病细胞系展现出显著的细胞杀伤能力。
T71456	Navitoclax dihydrochloride
	Navitoclax dihydrochloride is a synthetic small-molecule antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity.
T16694	Pyridoclax MR-29072	BCL	Apoptosis
	Pyridoclax is an inhibitor of potential Mcl-1.
T79852	Lacutoclax
	Lacutoclax为Bcl-2抑制剂，展现出抗肿瘤活性。
T78638	Clezutoclax
	Clezutoclax为Bcl-XL抑制剂且作为活性载体，可应用于抗体药物偶联物（ADC）的合成。
T22257	Murizatoclax	Others	Others
	AMG 397 is an oral MCL1 inhibitor .
T74015	Venetoclax N-oxide
	Venetoclax N-oxide 是 Venetoclax 的杂质。Venetoclax (ABT-199; GDC-0199) 是一种高效，选择性的和口服有效的Bcl-2抑制剂，Ki 小于0.01 nM。

化合物

Cat.No: T2119

Synonym: GDC-0199,ABT 199,维奈妥拉,ABT-199,ABT199

Target: BCL, Autophagy

Cat.No: T2101

Synonym: ABT-263

Target: BCL

Navitoclax-piperazine

Cat.No: T12186

Synonym: ABT-263-piperazine

Target: BCL, Ligands for Target Protein for PROTAC

Cat.No: T11944

Synonym: Marinopyrrole A

Target: BCL

Cat.No: T10483

Synonym: Bcl-2/Bcl-xl inhibitor 1,APG-2575

Target: BCL

Cat.No: T6650

Synonym: BI-97C1

Target: BCL

Obatoclax Mesylate

Cat.No: T6275

Synonym: Obatoclax,GX15-070,奥巴克拉甲磺酸盐

Target: BCL, Parasite, Autophagy

Desmorpholinyl Navitoclax-NH-Me

Cat.No: T39910

Synonym: Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me

Target: BCL

Cat.No: T14213

Synonym: AMG-176

Target: BCL

Cat.No: T41278

Cat.No: T27600

Cat.No: T36901

Cat.No: TMIH-0594

Cat.No: T74637

Navitoclax dihydrochloride

Cat.No: T71456

Cat.No: T16694

Synonym: MR-29072

Target: BCL

Cat.No: T79852

Cat.No: T78638

Cat.No: T22257

Target: Others

Venetoclax N-oxide

Cat.No: T74015

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01231	CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated OCILmember D,LLT1,CLAX,CLEC2D,CLAXLLT-1,LL...	Human	HEK293 Cells
	C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies.
TMPK-01230	CLEC2D Protein, Human, Recombinant (hFc & Avi) Lectin-like NK cell receptor,LLT-1,OCIL,LLT1,Lectin-like tra...	Human	HEK293 Cells
	C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. However, this implication may be confounded by highly active anti-retroviral treatment (HAART).

重组蛋白

CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPK-01231

Species: Human

Expression System: HEK293 Cells

CLEC2D Protein, Human, Recombinant (hFc & Avi)

Cat.No: TMPK-01230

Species: Human

Expression System: HEK293 Cells

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