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19

抑制剂 & 化合物

17

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T75103	CD19 CAR mRNA
	CD19CAR mRNA 能够编码CD19car蛋白，适用于CAR-T细胞免疫治疗（CAR-CD19）。CD19car作为嵌合抗原受体，针对B细胞表面的CD19，一种关键参与B细胞增殖、分化、活化及产生抗体的CD分子（即白细胞分化抗原），进而增强BCR信号传递。
T82466	Englumafusp alfa RG6076,CD19-4-1BBL,RO7227166
	Englumafusp alfa (CD19-4-1BBL; RO7227166)是一款由CD19特异性抗体域与人41BBL的三聚体胞外域结合构成的融合蛋白。该化合物能够促进T细胞与NK细胞表面CD19特异性4-1BB的交联作用。
T75104	CD19 CAR circRNA
	CD19CAR circRNA 可以表达 CD19car 蛋白，并且可用于嵌合抗原受体 T 细胞免疫疗法 (CAR-CD19)。CD19car 是一种嵌合抗原受体。其中 CD19是 B 细胞表达的一种 CD 分子 (即白细胞分化抗原)，参与 B 细胞增殖、分化、活化及抗体产生的重要膜抗原，还可促进 BCR 的信号转导。
T75114	CD19 car mRNA-LNP
	CD19car mRNA-LNP是一种脂质纳米粒(LNP)，内含CD19car mRNA，用于RNA传递、翻译效率和细胞活力检测。该产品应用于嵌合抗原受体T细胞免疫疗法(CAR-CD19)，CD19car作为嵌合抗原受体，针对B细胞表面的CD分子（即白细胞分化抗原）CD19，该分子在B细胞增殖、分化、活化及抗体产生中发挥关键作用，并促进BCR信号转导。
T75115	CD19 car circRNA-LNP
	CD19car circRNA-LNP是一个含CD19car circRNA的脂质纳米粒（LNP），用于RNA传递、翻译效率及细胞活力评估。CD19car circRNA适用于CAR-T细胞免疫疗法（CAR-CD19），CD19car作为一种嵌合抗原受体，而CD19是B细胞表面的CD分子，关键于B细胞的增殖、分化、激活和抗体生成，并促进BCR信号传递。
T80620	Anti-Mouse CD19 Antibody (1D3)
	Anti-MouseCD19Antibody (1D3) 为针对小鼠CD19的IgG2a亚型单克隆抗体。
T76713	Inebilizumab MEDI 551,MT-0551,16C4-aFuc,VIB-0551	Others	Others
	Inebilizumab 是一种人源化抗 CD19 单克隆抗体，对 B 细胞具有增强的抗体依赖细胞介导的细胞毒性。Inebilizumab 可用于治疗多发性硬化和视神经脊髓炎等一些与 CD19的B细胞相关的一系列自身免疫性疾病。
T77135	Tafasitamab MOR00208,XmAb5574,Tafasitamab-cxix	Apoptosis; Immunology/Inflammation related	Apoptosis; Immunology/Inflammation
	Tafasitamab (XmAb5574) 是一种 Fc 修饰的人源化单克隆抗体，靶向人 B 细胞表面抗原 CD19 ，可用于研究弥漫性大B细胞淋巴瘤。
TQ0291	Firategrast SB 683699	Integrin	Cytoskeletal Signaling
	Firategrast (SB 683699) 是一种具有口服活性和特异性的α4β1/α4β7整合素拮抗剂。Firategrast 减少淋巴细胞进入中枢神经系统 (CNS) 的运输，降低多发性硬化症 (MS) 的活性。Firategrast 用于复发缓解性多发性硬化症。Firategrast 治疗与中位脑脊液与 CD4，CD8和CD19淋巴细胞计数的适度降低有关。
T9901A-013	Coltuximab
	Coltuximab 是一种抗 CD19 的人源化单克隆抗体，B 淋巴细胞抗原 CD19 调节剂。
T80981	Tisagenlecleucel CTL019
	Tisagenlecleucel (CTL019) 是一种自体抗CD19嵌合抗原受体 (CAR) T 细胞治疗，专门针对并消除表达CD19的 B 细胞。该疗法主要用于研究治疗难治性侵袭性弥漫性大 B 细胞淋巴瘤。
T81042	Taplitumomab paptox
	Taplitumomab paptox为针对CD19的单克隆抗体，主要应用于癌症研究领域。
T80606	Duvortuxizumab MGD 011
	Duvortuxizumab (MGD 011) 是一种嵌合人源化IG抗体，特异性靶向CD19和CD3E。
T76854	Loncastuximab tesirine
	Loncastuximab tesirine 是一种人簇分化 19 (CD19) 靶向的抗体-活性分子偶联物 (ADC)。一旦与细胞膜上的 CD19结合，Loncastuximab tesirine 被迅速内化，引发细胞死亡。Loncastuximab tesirin 诱导细胞凋亡，可用于弥漫型 B 细胞淋巴瘤的研究。
T76801	Denintuzumab
	Denintuzumab (hBU 12) 是一种重组人源化抗 CD19单克隆抗体。Denintuzumab 可作为抗体偶联活性分子的抗体部分 (ADC antibody) 合成 ADC，Denintuzumab Mafodotin (SGN-CD19A)。Denintuzumab Mafodotin 可用于急性淋巴细胞白血病的研究。
T81624	Obexelimab XmAb5871
	Obexelimab (XmAb5871)为通过Fc工程改良，增强其对FcγRIIb亲和力的人源化抗CD19抗体，适用于自身免疫病的研究。
T77070	Loncastuximab
	Loncastuximab (RB4v1.2)，一种针对CD19的单克隆抗体，主要具有抗肿瘤活性，尤其在非霍奇金淋巴瘤（NHL），包括弥漫性大B细胞淋巴瘤（DLBCL）中展现出潜在应用价值。
T78317	Blinatumomab Anatumomab
	Blinatumomab（亦称Anatumomab）是针对B细胞表面CD19抗原的双特异性单克隆抗体，主要用于急性淋巴细胞白血病的研究。
T81829	MDX-1342
	MDX-1342是一种针对CD19膜受体的全人源单克隆抗体(HuMAb)，能够高度亲和且特异性地与人CD19抗原结合，展现出抗体依赖性细胞毒性（ADCC）效应。该抗体在研究B淋巴细胞恶性肿瘤以及自身免疫性疾病中具有应用潜力。

化合物

Cat.No: T75103

Englumafusp alfa

Cat.No: T82466

Synonym: RG6076,CD19-4-1BBL,RO7227166

CD19 CAR circRNA

Cat.No: T75104

CD19 car mRNA-LNP

Cat.No: T75114

CD19 car circRNA-LNP

Cat.No: T75115

Anti-Mouse CD19 Antibody (1D3)

Cat.No: T80620

Cat.No: T76713

Synonym: MEDI 551,MT-0551,16C4-aFuc,VIB-0551

Target: Others

Cat.No: T77135

Synonym: MOR00208,XmAb5574,Tafasitamab-cxix

Target: Apoptosis, Immunology/Inflammation related

Cat.No: TQ0291

Synonym: SB 683699

Target: Integrin

Cat.No: T9901A-013

Tisagenlecleucel

Cat.No: T80981

Synonym: CTL019

Taplitumomab paptox

Cat.No: T81042

Cat.No: T80606

Synonym: MGD 011

Loncastuximab tesirine

Cat.No: T76854

Cat.No: T76801

Cat.No: T81624

Synonym: XmAb5871

Cat.No: T77070

Cat.No: T78317

Synonym: Anatumomab

Cat.No: T81829

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01741	CD19 Protein, Mouse, Recombinant (His) AW495831,CD19 molecule	Mouse	HEK293 Cells
	CD19 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.1 kDa and the accession number is P25918.
TMPY-05427	CD19 Protein, Human, Recombinant (hFc) CVID3,B4,CD19 molecule	Human	HEK293 Cells
	CD19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is P15391-2.
TMPY-05530	CD19 Protein, Cynomolgus/Rhesus, Recombinant (His), Biotinylated CD19 molecule	Cynomolgus,Rhesus	HEK293 Cells
	CD19 Protein, Cynomolgus/Rhesus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.4 kDa and the accession number is XP_005591597.1.
TMPY-05540	CD19 Protein, Mouse, Recombinant (His), Biotinylated CD19 molecule,AW495831	Mouse	HEK293 Cells
	CD19 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is P25918.
TMPY-01949	CD19 Protein, Human, Recombinant (His) CD19 molecule,B4,CVID3	Human	HEK293 Cells
	CD19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is P15391-1.
TMPY-05127	CD19 Protein, Human, Recombinant (His), Biotinylated CD19 molecule,CVID3,B4	Human	HEK293 Cells
	CD19 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is P15391.
TMPJ-00329	CD19 Protein, Rhesus macaque, Recombinant (hFc) B-Lymphocyte Antigen CD19,CD1...	Rhesus	HEK293 Cells
	CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Sr...
TMPY-06681	CD19 Protein, Rat, Recombinant (His) CD19 molecule	Rat	HEK293 Cells
	CD19 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.11 kDa and the accession number is NP_001013255.2.
TMPY-04729	CD19 Protein, Cynomolgus, Rhesus, Recombinant (hFc) CD19 molecule	Cynomolgus,Rhesus	HEK293 Cells
	CD19 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57 kDa and the accession number is XP_005591597.1.
TMPY-05420	CD19 Protein, Cynomolgus, Rhesus, Recombinant (His) CD19 molecule	Cynomolgus,Rhesus	HEK293 Cells
	CD19 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.4 kDa and the accession number is XP_005591597.1.
TMPY-06320	CD19 Protein, Human, Recombinant (hFc & Avi), Biotinylated CVID3,B4,CD19 molecule	Human	HEK293 Cells
	CD19 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 58.65 kDa and the accession number is NP_001171569.1.
TMPY-06755	CD19 Protein, Human, Recombinant (His & Avi), Biotinylated B4,CD19 molecule,CVID3	Human	HEK293 Cells
	CD19 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 33.37 kDa and the accession number is P15391-1.
TMPK-00327	CD19 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) CVID3,CD19,MGC12802,B4,Leu-12	Cynomolgus,Rhesus	HEK293 Cells
	CD19 is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses.Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca2 stores.
TMPK-00100	CD7 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated TP41,CD7,CD7 molecule,Tp40,LEU-9,GP40	Mouse	HEK293 Cells
	CD7, also known as Leu-9, is an approximately 40 kDa glycosylated and palmitoylated transmembrane protein in the immunoglobulin superfamily.CD7 is expressed on T cells, NK cells , myeloid progenitor cells, and CD19 B progenitor cells. Among CD8 T cells, the CD7-bright population preferentially contains naïve and memory cells, while more weak expressors are primarily effector cells. CD7 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells...
TMPK-00129	CD7 Protein, Human, Recombinant (His & Avi) CD7,GP40,Tp40,CD7 molecule,LEU-9,TP41	Human	HEK293 Cells
	CD7, also known as Leu-9, is an approximately 40 kDa glycosylated and palmitoylated transmembrane protein in the immunoglobulin superfamily.CD7 is expressed on T cells, NK cells , myeloid progenitor cells, and CD19 B progenitor cells. Among CD8 T cells, the CD7-bright population preferentially contains naïve and memory cells, while more weak expressors are primarily effector cells. CD7 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicte...
TMPK-00128	CD7 Protein, Human, Recombinant (His & Avi), PE-Labeled LEU-9,TP41,CD7 molecule,Tp40,CD7,GP40	Human	HEK293 Cells
	CD7, also known as Leu-9, is an approximately 40 kDa glycosylated and palmitoylated transmembrane protein in the immunoglobulin superfamily.CD7 is expressed on T cells, NK cells , myeloid progenitor cells, and CD19 B progenitor cells. Among CD8 T cells, the CD7-bright population preferentially contains naïve and memory cells, while more weak expressors are primarily effector cells. CD7 Protein, Human, Recombinant (His & Avi), PE-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. ...
TMPY-02810	Ninjurin-1 Protein, Rat, Recombinant (hFc) ninjurin 1	Rat	HEK293 Cells
	Ninjurin-1, also known as NINJ1, is a member of the Ninjurin family of transmembrane (TM) proteins. It is expressed in CD19(+) CD10(+) B-cell progenitor cells and higher levels in B-lineage acute lymphoblastic leukemia cells. Ninjurin-1 is expressed also in some other adult and embryonic tissues, predominantly in epithelial cells. Its expression is upregulated after axotomy in neurons and Schwann cells surrounding the distal nerve segment. Upregulated expression of ninjurin-1 has been identified...

重组蛋白

CD19 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01741

Species: Mouse

Expression System: HEK293 Cells

CD19 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05427

Species: Human

Expression System: HEK293 Cells

CD19 Protein, Cynomolgus/Rhesus, Recombinant (His), Biotinylated

Cat.No: TMPY-05530

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CD19 Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-05540

Species: Mouse

Expression System: HEK293 Cells

CD19 Protein, Human, Recombinant (His)

Cat.No: TMPY-01949

Species: Human

Expression System: HEK293 Cells

CD19 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05127

Species: Human

Expression System: HEK293 Cells

CD19 Protein, Rhesus macaque, Recombinant (hFc)

Cat.No: TMPJ-00329

Species: Rhesus

Expression System: HEK293 Cells

CD19 Protein, Rat, Recombinant (His)

Cat.No: TMPY-06681

Species: Rat

Expression System: HEK293 Cells

CD19 Protein, Cynomolgus, Rhesus, Recombinant (hFc)

Cat.No: TMPY-04729

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CD19 Protein, Cynomolgus, Rhesus, Recombinant (His)

Cat.No: TMPY-05420

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CD19 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06320

Species: Human

Expression System: HEK293 Cells

CD19 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06755

Species: Human

Expression System: HEK293 Cells

CD19 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00327

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CD7 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00100

Species: Mouse

Expression System: HEK293 Cells

CD7 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00129

Species: Human

Expression System: HEK293 Cells

CD7 Protein, Human, Recombinant (His & Avi), PE-Labeled

Cat.No: TMPK-00128

Species: Human

Expression System: HEK293 Cells

Ninjurin-1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-02810

Species: Rat

Expression System: HEK293 Cells

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