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Search Results for " cb2 receptor agonist 2 "

17

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T22009	CB2 receptor agonist 2 ZINC72105556,4-Quinolone-3-Carboxamide Furan CB2 Agonist,CB2受体拮抗剂2	Cannabinoid Receptor	GPCR/G Protein
	CB2 receptor agonist 2 (ZINC72105556) 是有效和选择性的 CB2 受体激动剂。对 CB2 的 Ki 为 8.5 nM。CB2 receptor agonist 2 对 CB2 具有高亲和力和选择性。
T24097	CB2 receptor agonist 3 GP-2A,GP 2A,GP2A
	GP 2A is a selective agonist of CB2 receptor.
T6417	BML-190 2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]-1-(4-吗啉基)乙酮,Indomethacin morpholinylamide,吲哚美辛吗啉代酰胺,IMMA,BML 190	Cannabinoid Receptor	GPCR/G Protein
	BML-190 (Indomethacin morpholinylamide) 是一种 CB2 受体的配体，其对 CB2 受体 (Ki:435 nM) 和 CB1受体 (Ki> 2 μM)。
T6527	GW842166X 2-(2,4-二氯苯基氨基)-4-三氟甲基嘧啶-5-羧酸[(四氢吡喃-4-基)甲基]酰胺	Cannabinoid Receptor	GPCR/G Protein
	GW842166X 是一种选择性 cannabinoid receptor 2 激活剂，IC50=63 nM。
T7316	LY2828360	Cannabinoid Receptor	GPCR/G Protein
	LY2828360 是一种作用缓慢的、有效的 G 蛋白偏倚的大麻素受体 2(CB2)激动剂，能够抑制 cAMP 的积累并激活 ERK1/2 通路。
T14302	Olorinab APD 371	Cannabinoid Receptor	GPCR/G Protein
	Olorinab (APD 371) (APD 371) 是大麻素受体 2 型 (CB2) 强有效的、选择性的全激动剂，其对 hCB2 的EC50 值为 6.2 nM。
T41231	GP 1a	Cannabinoid Receptor; PERK; Arrestin	Apoptosis; GPCR/G Protein
	GP 1a 是cannabinoid receptor 2（CB2）的强效激动剂（EC50=7.1),是在cAMP、GTPγS 和β-arrestin 招募试验中显示的。GP 1a 对CB2受体的选择性约为CB1受体的30倍，且在体外增加HL-60细胞的P-ERK1/2表达。GP 1a 对皮肤伤口愈合有益。GP 1a 可抑制炎症和纤维生成，同时促进上皮的重新形成。
T24771	SCH-336 SCH336,SCH 336	Cannabinoid Receptor	GPCR/G Protein
	SCH-336是一种 CB2受体激动剂(Ki-1.8 nM, EC50-2 nM)，具有有效性，选择性和口服活性。SCH-336对 CB1受体也具有生物活性，对CB2受体的选择性是CB1的100倍。SCH-336能够减少鸟苷5'-3- o -(硫)三磷酸与含hCB 的膜的结合，抑制 BaF3/CB2 细胞迁移，抑制小鼠延迟型超敏反应模型中的白细胞迁移，抑制小鼠过敏模型中抗原诱导的肺嗜酸性粒细胞增多。
T17027	Tedalinab GRC-10693	Cannabinoid Receptor	GPCR/G Protein
	Tedalinab is an effective and selective cannabinoid receptor 2 agonist. Tedalinab has the potential for neuropathic pain and osteoarthritis treatment. Tedalinab has >4700-fold functional selectivity for CB2 over CB1.
T38912	Vicasinabin
	Vicasinabin, a potent agonist of cannabinoid receptor 2 (CB2), exhibits promising potential for researching chronic pain, atherosclerosis, regulation of bone mass, neuroinflammation, and related human diseases.
T62132	S-777469
	S-777469 是一种选择性的、口服具有活力的大麻素 2 型受体(CB2)激动剂 (Ki: 36 nM)。S-777469 能够剂量依赖性地明显抑制化合物 48/80 诱导的小鼠抓挠行为。S-777469 兴奋 CB2，抑制瘙痒信号的传递，显示出止痒效果。
T38199	(±)-WIN 55,212 (mesylate)
	(±)-WIN 55,212-2 is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki value of 62.3 and 3.3 nM for human recombinant central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, respectively. In contrast, the enantiomer (-)-WIN 55,212-3 acts a partial inverse agonist at CB1 (pIC50 = 5.5) and as a competitive neutral antagonist of CB2, reversing the inverse agonism evoked by SR 144528 (pEC50 = 5.3). (+)-WIN 55,212 (mesylate) is a mixture of the two enantiomers, (+)-WI...
T68904	GW-833972A free base
	GW833972 is a CB2 Agonist. GW 833972A inhibited capsaicin-induced depolarization of the human and guinea-pig and prostaglandin E(2) (PGE(2)) and hypertonic saline-induced depolarization of the guinea-pig isolated vagus nerve in vitro. GW 833972A also inhibited citric acid-induced cough but not plasma extravasation in the guinea-pig and this effect was blocked by a CB(2) receptor antagonist.
T75936	RVD-Hpα TFA
	RVD-Hpα TFA is the N-terminally extended form of human hemopressin that acts as a selectiveCB1receptoragonist. RVD-Hpα TFA increases intracellular Ca2+levels in cells expressingCB1receptors in vitro. RVD-Hpα TFA also high affinityCB2positive allosteric modulator (Ki=50 nM).
T38138	ACEA 2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide
	Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide , in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in ...
T27809	LEI-101
	LEI-101 是有效的、选择性的、具有口服活性的大麻素CB2受体激动剂。LEI-101对 hCB2 的 pEC50值为 8，对 hERG 的 pKi 值小于 4。LEI-101 与 CB2 受体的结合能力比 CB1 强100 倍。LEI-101 具有炎症及氧化应激相关疾病的治疗潜力。
T35468	(±)19(20)-EDP Ethanolamide
	(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-...

化合物

CB2 receptor agonist 2

Cat.No: T22009

Synonym: ZINC72105556,4-Quinolone-3-Carboxamide Furan CB2 Agonist,CB2受体拮抗剂2

Target: Cannabinoid Receptor

CB2 receptor agonist 3

Cat.No: T24097

Synonym: GP-2A,GP 2A,GP2A

Cat.No: T6417

Synonym: 2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]-1-(4-吗啉基)乙酮,Indomethacin morpholinylamide,吲哚美辛吗啉代酰胺,IMMA,BML 190

Target: Cannabinoid Receptor

Cat.No: T6527

Synonym: 2-(2,4-二氯苯基氨基)-4-三氟甲基嘧啶-5-羧酸[(四氢吡喃-4-基)甲基]酰胺

Target: Cannabinoid Receptor

Cat.No: T7316

Target: Cannabinoid Receptor

Cat.No: T14302

Synonym: APD 371

Target: Cannabinoid Receptor

Cat.No: T41231

Target: Cannabinoid Receptor, PERK, Arrestin

Cat.No: T24771

Synonym: SCH336,SCH 336

Target: Cannabinoid Receptor

Cat.No: T17027

Synonym: GRC-10693

Target: Cannabinoid Receptor

Cat.No: T38912

Cat.No: T62132

(±)-WIN 55,212 (mesylate)

Cat.No: T38199

GW-833972A free base

Cat.No: T68904

Cat.No: T75936

Cat.No: T38138

Synonym: 2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide

Cat.No: T27809

(±)19(20)-EDP Ethanolamide

Cat.No: T35468

Cat. No.	Product Name	Target	Signaling Pathways
TN1465	Cannabigerol	NOS; 5-HT Receptor; ROS	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cannabigerol 是一种植物大麻素，是一种高亲和力 α2-肾上腺素能受体激动剂、中度亲和力 5-HT1A 受体拮抗剂和低亲和力 CB1/CB2受体拮抗剂。它可降低眼压，有潜力治疗青光眼。

天然产物

Cat.No: TN1465

Target: NOS, 5-HT Receptor, ROS

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