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Cat. No. | Product Name | Target | Signaling Pathways |
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T10641 |
C-82
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Epigenetic Reader Domain; Wnt/beta-catenin | Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells |
C-82 是一种特异性 CBP/β-catenin 拮抗剂。它抑制 β-catenin 和 CBP 之间的结合,并增加 β-catenin 和 p300 之间的结合。 | |||
TP1516L |
C-Reactive Protein (CRP) 77-82 acetate
C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base) |
Others | Others |
C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base) 是 C-反应蛋白的 77-82 片段。 C-反应蛋白 (CRP) 是炎症的原型标志物,是心血管风险标志物,可能促进动脉粥样硬化。C-反应蛋白 (CRP) 是一种环状(环状)五聚体蛋白,存在于血浆中,其循环浓度炎症反应而升高。它是一种肝脏来源的急性期蛋白,在巨噬细胞和 T 细胞分泌 IL-6 后会增加。 | |||
T64414 |
PRI-724
C-82 prodrug,Foscenvivint |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
PRI-724 (C-82 prodrug)是β-catenin/CBP 相互作用的选择性小分子抑制剂。 | |||
TP1516 |
C-Reactive Protein (CRP) (77-82)
C-Reactive Protein (CRP) 77-82 |
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C-Reactive Protein (CRP) 77-82 is the 77-82 fragment of C-Reactive Protein. C-Reactive Protein (CRP), the prototypic marker of inflammation, is a cardiovascular risk marker and may promote atherogenesis.C-reactive protein (CRP) is an annular (ring-shaped) | |||
T1415 |
Gemfibrozil
吉非罗齐,CI-719,Jezil,Decrelip,Lopid |
P450; Adrenergic Receptor; PPAR | DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Gemfibrozil (CI-719) 是一种PPAR-α激活剂,可作为降脂药。它也是P450非选择性抑制剂,对 CYP2C9、2C19、2C8 和 1A2 的Ki 值分别为 5.8、24、69 和 82 μM。 | |||
T10650 | c-Kit-IN-2 | c-Kit | Tyrosine Kinase/Adaptors |
c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (GI50s: 1, 3, and 2 nM). | |||
T126099 | Rabdoternin C | ||
Rabdoternin C 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126099,CAS号为 128887-82-1。 | |||
T69821 |
AMP423
|
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AMP423 is a naphthyl derivative of 2-cyanoaziridine-1-carboxamide with structural similarity to the pro-oxidant anti-tumor agent imexon. AMP423 was active in SCID mice bearing 8226/S myeloma and SU-DHL-6 B-cell lymphoma tumors, with a median tumor growth delay (T-C) of 21 days (P = 0.0002) and 5 days (P = 0.004), respectively, and a median tumor growth inhibition (T/C) of 33.3% (P = 0.03) and 82% (P = 0.01), respectively. In non-tumor-bearing mice, AMP423 was not myelosuppressive. | |||
T35864 |
T-5342126
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T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-depen... | |||
T37594 |
Pericosine A
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Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable t... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T36295 | Echistatin TFA | ||
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ... |