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Cat. No.	Product Name	Target	Signaling Pathways
T10483	Lisaftoclax Bcl-2/Bcl-xl inhibitor 1,APG-2575	BCL	Apoptosis
	Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) 是一种双重 Bcl-2 和 Bcl-xl 抑制剂(IC50：2 nM 和 5.9 nM)，具有抗肿瘤活性。
T6281	TW-37 TW 37	BCL	Apoptosis
	TW-37 是重组 Bcl-2、Bcl-xL 和 Mcl-1 的非肽抑制剂，Ki 值分别为 0.26、0.29和1.11μM
T6748	A-1155463 A 1155463,A1155463,醋酸艾塞那肽	BCL	Apoptosis
	A-1155463是一种高效选择性的BCL-XL 抑制剂，对 BCL-XL 具有皮摩尔的结合亲和力，在Molt-4细胞中的EC50值为70 nM。
T39910	Desmorpholinyl Navitoclax-NH-Me Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me	BCL	Apoptosis
	Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2].
T6650	Sabutoclax BI-97C1	BCL	Apoptosis
	Sabutoclax (BI-97C1) 是一种泛 Bcl-2 抑制剂，包括 Bcl-xL、Bcl-2、Mcl-1 和 Bfl-1，IC50 分别为 0.31 μM、0.32 μM、0.20 μM 和 0.62 μM。
T2101	Navitoclax ABT-263	BCL	Apoptosis
	Navitoclax (ABT-263) 是一种 Bcl-2 抑制剂，可与 Bcl-xL、Bcl-2、Bcl-w 等蛋白结合 (Ki<1 nM)，具有有效性和口服活性。Navitoclax 具有抗肿瘤活性，可以诱导细胞凋亡。
T9014	SKI-178	Apoptosis; S1P Receptor	Apoptosis; GPCR/G Protein
	SKI-178 是一种鞘氨醇激酶-1(SphK1)和 SphK2抑制剂，以 CDK1 依赖性方式诱导人急性髓性白血病细胞凋亡。
T36884	BM-1244
	BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM[1].
T36901	Pelcitoclax
	Pelcitoclax (APG-1252) is a powerful inhibitor of the Bcl-2 and Bcl-xl proteins, displaying significant antineoplastic and pro-apoptotic properties[1].
T10577	BM 957	BCL	Apoptosis
	BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).
T36883	BM-1074
	BM-1074 is a potent and highly efficacious inhibitor of Bcl-2/Bcl-xL with Ki value of < 1nM [1].
T79377	NWP-0476
	NWP-0476为针对BCL-2/BCL-xL的抑制剂，其结构已优化以提高对BCL-xL的选择性。该化合物适用于复发性T-急性淋巴细胞白血病（T-ALL）的相关研究。
T40070	S65487 sulfate VOB560 sulfate
	S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y. It exhibits poor affinity for MCL-1, BFL-1, and BCL-XL. Additionally, S65487 sulfate induces apoptosis and possesses anticancer activities.
T36897	S65487
	S65487 (VOB560) is a potent and selective Bcl-2 inhibitor. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities[1][2].
T79171	Bcl-2-IN-11
	Bcl-2-IN-11（compound 6）是高效选择性的Bcl-2抑制剂，具有0.9 nM的IC50。相对于Bcl-xl，其抑制作用较弱（IC50 > 1000 nM）。该化合物主要用于研究因Bcl-2家族蛋白过量表达引起的多种癌症，尤其适用于急性淋巴性白血病等恶性血液疾病。同时，Bcl-2-IN-11可以减少由Bcl-xl抑制相关的副作用，例如减少血小板。
T39135	S65487 hydrochloride S65487 hydrochloride,VOB560 hydrochloride
	S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y. It exhibits poor affinity for MCL-1, BFL-1, and BCL-XL. This compound induces apoptosis and possesses anticancer activities.
T40230	Mcl-1 inhibitor 6
	Mcl-1 inhibitor 6 is a potent, orally active chemical compound that selectively inhibits the myeloid cell leukemia 1 (Mcl-1) protein, with a high affinity (K d = 0.23 nM) and binding activity (K i = 0.02 μM). This compound exhibits exceptional selectivity over other members of the Bcl-2 family, including Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w (K d >10 μM). Notably, Mcl-1 inhibitor 6 demonstrates strong antitumor activity.
T21786	Apogossypolone (ApoG2)
	Apogossypolone (ApoG2) 是一种具有口服活性的Bcl-2 家族蛋白抑制剂，对 Bcl-2, Mcl-1 和 Bcl-XL 的Ki 值分别为 35, 25 和 660 nM。Apogossypolone 具有抗肿瘤活性，可诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。Apogossypolone 具有抗真菌活性。

化合物

Cat.No: T10483

Synonym: Bcl-2/Bcl-xl inhibitor 1,APG-2575

Target: BCL

Cat.No: T6281

Synonym: TW 37

Target: BCL

Cat.No: T6748

Synonym: A 1155463,A1155463,醋酸艾塞那肽

Target: BCL

Desmorpholinyl Navitoclax-NH-Me

Cat.No: T39910

Synonym: Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me

Target: BCL

Cat.No: T6650

Synonym: BI-97C1

Target: BCL

Cat.No: T2101

Synonym: ABT-263

Target: BCL

Cat.No: T9014

Target: Apoptosis, S1P Receptor

Cat.No: T36884

Cat.No: T36901

Cat.No: T10577

Target: BCL

Cat.No: T36883

Cat.No: T79377

Cat.No: T40070

Synonym: VOB560 sulfate

Cat.No: T36897

Cat.No: T79171

S65487 hydrochloride

Cat.No: T39135

Synonym: S65487 hydrochloride,VOB560 hydrochloride

Mcl-1 inhibitor 6

Cat.No: T40230

Apogossypolone (ApoG2)

Cat.No: T21786

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