Name: SKI-178
Brand: TargetMol
SKU: T9014
Price: 247 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 247

现货

2 mg

¥ 359

现货

5 mg

¥ 622

现货

10 mg

¥ 1,080

现货

25 mg

¥ 1,980

现货

50 mg

¥ 3,320

现货

100 mg

¥ 4,880

现货

500 mg

¥ 9,870

现货

1 mL x 10 mM (in DMSO)

¥ 688

现货

产品介绍

生物活性

产品描述	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
靶点活性	SPHK1:0.1-1.8 μM
体外活性	SKI-178是一种多靶向药物，既能抑制SphKs也能破坏微管网络。由于这两种活动的协同作用，SKI-178能引起细胞凋亡。在小鼠的AML模型中，SKI-178表现出安全性和有效性，支持其作为多靶向抗癌治疗药物的进一步开发[1]。

化学信息

分子量	394.42
分子式	C₂₁H₂₂N₄O₄
CAS No.	1259484-97-3
Smiles	COc1ccc(cc1)-c1cc([nH]n1)C(=O)N\N=C(/C)c1ccc(OC)c(OC)c1
密度	1.24 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (126.77 mM), Sonication is recommended.

溶液配制表

DMSO

体内实验配液计算器