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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10557 | BLM-IN-1 | Others | Others |
BLM-IN-1 is an effective Bloom syndrome protein (BLM) inhibitor (KD: 1.81 μM; IC50: 0.95 μM). It induces DNA damage response, apoptosis and proliferation arrest in cancer cells | |||
T73391 |
BLM-IN-2
|
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BLM-IN-2是一种针对布鲁姆氏综合征蛋白(BLM)的抑制剂,IC50为0.8 μM。该化合物能够有效抑制结直肠癌(CRC)细胞的增殖、侵袭、诱导细胞周期阻滞及凋亡,因此适用于结直肠癌的研究。 | |||
T77903 |
Belantamab mafodotin
Belantamab mafodotin-blm,GSK2857916 |
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Belantamab mafodotin (GSK2857916) 为人源化的抗B细胞成熟抗原(BCMA)单克隆抗体与McMMAF共轭物,展现出对骨髓瘤的治疗活性。 | |||
T5413 |
ML216
CID-49852229 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
ML216 (CID-49852229) 是一种选择性、细胞渗透性的BLM 解旋酶抑制剂,具有抗肿瘤活性。它对BLMfull-length 和BLM636-1298的IC50分别为 2.98 μM 和 0.97 μM。 | |||
T38709 |
PFM39
|
Others | Others |
PFM39 是一种选择性 MRE11 核酸外切酶抑制剂,是 Mirin 类似物,可延长有丝分裂。PFM39 抑制 HR,可缓解由 EXO1/BLM 耗竭引起的修复缺陷。 | |||
T40823 |
NCGC00029283
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively. | |||
T82938 |
ATUX-1215
|
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ATUX-1215是一种蛋白磷酸酶 2A (PP2A)的激活剂,能够在BLM治疗的动物模型中降低ERK、p38、JNK和Akt的磷酸化及IL-12p70、GM-CSF与IL1α的分泌,从而有助于减缓肺纤维化的发展。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN3469 |
Aucuparin
2,6-dimethoxy-4-phenylphenol |
NADPH-oxidase | Immunology/Inflammation |
Aucuparin (2,6-dimethoxy-4-phenylphenol) 是一种植物抗菌素,具有抗炎活性。 在博来霉素 (BLM) 诱导的肺纤维化小鼠模型中,Aucuparin 抑制肺纤维化。 在经ABTS 和FRAP 测定显示出明显的清除活性。 Aucuparin 对fmlp 诱导的人中性粒细胞产生超氧化物具有明显的抑制作用,其IC50为17.0μM。 | |||
T4953 |
Neotuberostemonine
|
NOS | Immunology/Inflammation |
Neotuberostemonine 是一种结核分枝杆菌根中主要的止咳生物碱,能够阻碍巨噬细胞的募集和活化,从而减轻博来霉素 (Bleomycin) 诱导的肺纤维化。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02550 |
BLM Protein, Mouse, Recombinant (His & Myc)
BLM,Bloom syndrome protein,RecQ-like DNA helicase <... |
Mouse | E. coli |
BLM Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.7 kDa and the accession number is O88700. | |||
TMPH-01010 |
BLM Protein, Human, Recombinant (His)
RecQ-like DNA helicase BLM,BLM,RecQ protei... |
Human | E. coli |
BLM Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.0 kDa and the accession number is P54132. | |||
TMPY-01865 |
BLMH Protein, Mouse, Recombinant (His)
Bh,bleomycin hydrolase,Bmh,AI035728 |
Mouse | E. coli |
The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The papain superfamily member bleomycin hydrolase (BLMH) is a neutral cysteine protease with structural similarity to a 20S proteasome. Bleomycin (BLM), a clinically used glycopeptide antica... |