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Search Results for " arginase "

16

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T76208	Arginase
	Arginase 是尿素循环的一种酶。Arginase 催化 L-精氨酸水解为 L-鸟氨酸和尿素。
T10367	Arginase inhibitor 1	Others	Others
	Arginase inhibitor 1 is a potent inhibitor of human arginases I and II (IC50s: 223 and 509 nM).
T6779	BEC hydrochloride BEC HCl	Arginase	Immunology/Inflammation
	BEC hydrochloride (BEC HCl) 是一种缓慢结合的竞争性精氨酸酶 II 抑制剂，在 pH 7.5 时 Ki 值为 0.31 μM。它对大鼠 Arginase I 在 0.4 到 0.6 μM 之间。
T12240	nor-NOHA acetate Nω-Hydroxy-nor-L-arginine acetate	Apoptosis; Arginase	Apoptosis; Immunology/Inflammation
	nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) 是一种可逆的精氨酸酶抑制剂，具有抗白血病的作用，对内皮功能障碍、免疫抑制和代谢有效。在缺氧条件下，它可诱导 ARG2 表达细胞的凋亡。
T9096	Nω-Hydroxy-nor-L-Arginine Dihydrochloride	Arginase	Immunology/Inflammation
	Nω-Hydroxy-nor-L-Arginine Dihydrochloride 是一种竞争性和可逆的精氨酸酶抑制剂。
T39766	Nor-NOHA monoacetate Nor NOHA monoacetate,Nω-Hydroxy-nor-L-arginine monoacetate	Arginase	Immunology/Inflammation
	nor-NOHA monoacetate (Nω-Hydroxy-nor-L-arginine) 是一种具有高效性和选择性的精氨酸酶抑制剂。nor-NOHA monoacetate 抑制大鼠肝精氨酸酶，抑制L-精氨酸水解，可用于研究心血管和阻塞性气道疾病。
T12206	NED-3238	Others	Others
	NED-3238 is a highly potent inhibitor of arginase I and II (IC50 of 1.3 nM and 8.1 nM, respectively).
T10692	CB-1158 dihydrochloride (2095732-06-0 free base) INCB01158 dihydrochloride,CB-1158 dihydrochloride	Others	Others
	CB-1158 dihydrochloride is an effective and orally active inhibitor of arginase (IC50s: 86 nM and 296 nM for recombinant human arginase 1 and 2).
T10692L	Numidargistat INCB01158,CB-1158	Others	Others
	CB-1158 is a potent and orally bioavailable inhibitor of arginase (IC50s: 86 and 296 nM for recombinant human arginase 1 and 2).
T26516	ABH Hydrochloride 6-borono-L-norleucine,ABH HCl
	ABH Hydrochloride is an arginase inhibitor, it enhances both male and female sexual arousal responses.
T39932	ARG1-IN-1 ARG1-IN-1
	ARG1-IN-1 is a human arginase 1 inhibitor with an IC 50 of 29 nM.
T61336	Numidargistat dihydrochloride
	Numidargistat dihydrochloride (CB-1158) is a highly potent and orally active chemical compound that effectively inhibits arginase. It exhibits IC50 values of 86 nM and 296 nM for recombinant human arginase 1 and 2, respectively. Numidargistat dihydrochloride contributes to immuno-oncology, making it a valuable agent in the field [1].
T70367	SNU-BP
	SNU-BP is an agonist of PPAR-gamma, inhibiting lipopolysaccharide (LPS)-induced NO production and pro-inflammatory cytokines. SNU-BP potentiates interleukin-4-induced arginase-1 expression, and promotes microglial polarization toward an M2 anti-inflammatory phenotype.
T78656	ARG1-IN-1 hydrochloride	Arginase	Immunology/Inflammation
	ARG1-IN-1 (example 1) hydrochloride为一种针对人类精氨酸酶1的抑制剂，具有29 nM的IC50值。
T70928	CB-1158-analog
	CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent and in combination with checkpoint blockade, adoptive T cell therapy, adoptive NK cell therapy, and the chemotherapy agent gemcitabine. CB-1158 increased tumor-infiltrating CD8+ T cells and NK cell...
T83779	EP4 Antagonist 14 Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
	EP4 antagonist 14是一种前列腺素E2（PGE2）受体亚型EP4的拮抗剂，其在使用表达人源受体的HEK293细胞的报告基因测定中的IC50值为1.1 nM。它还能抑制PGE2诱导的同种细胞中的β-阿雷斯汀招募（IC50 = 0.9 nM）。EP4 antagonist 14（10 µM）能减少RAW 264.7巨噬细胞中PGE2诱导的mRNA表达，这些mRNA编码Il-4、巨噬细胞甘露糖受体1（Mrc1）、几丁质酶样蛋白3（Chil3）、趋化因子（C-X-C）基序配体1（Cxcl1）、表达在髓样细胞上的触发受体2（Trem2）和精氨酸酶-1（Arg1）。在体内，EP4 antagonist 14（每天30 mg/kg），结合抗PD-1抗体，能够在CT26小鼠结肠癌模型中抑制肿瘤生长并增加CD8+ T细胞对肿瘤的浸润。

化合物

Cat.No: T76208

Arginase inhibitor 1

Cat.No: T10367

Target: Others

BEC hydrochloride

Cat.No: T6779

Synonym: BEC HCl

Target: Arginase

nor-NOHA acetate

Cat.No: T12240

Synonym: Nω-Hydroxy-nor-L-arginine acetate

Target: Apoptosis, Arginase

Nω-Hydroxy-nor-L-Arginine Dihydrochloride

Cat.No: T9096

Target: Arginase

Nor-NOHA monoacetate

Cat.No: T39766

Synonym: Nor NOHA monoacetate,Nω-Hydroxy-nor-L-arginine monoacetate

Target: Arginase

Cat.No: T12206

Target: Others

CB-1158 dihydrochloride (2095732-06-0 free base)

Cat.No: T10692

Synonym: INCB01158 dihydrochloride,CB-1158 dihydrochloride

Target: Others

Cat.No: T10692L

Synonym: INCB01158,CB-1158

Target: Others

ABH Hydrochloride

Cat.No: T26516

Synonym: 6-borono-L-norleucine,ABH HCl

Cat.No: T39932

Synonym: ARG1-IN-1

Numidargistat dihydrochloride

Cat.No: T61336

Cat.No: T70367

ARG1-IN-1 hydrochloride

Cat.No: T78656

Target: Arginase

Cat.No: T70928

EP4 Antagonist 14

Cat.No: T83779

Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14

Cat. No.	Product Name	Target	Signaling Pathways
T11054	DL-Norvaline 2-Aminopentanoic acid,DL-正缬氨酸	Arginase; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	DL-Norvaline (2-Aminopentanoic acid) 是精氨酸酶的非竞争性抑制剂，是L-norvaline 的代谢物。
T3S0401	Piceatannol 3'-O-glucoside 白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷	Arginase; NO Synthase	Immunology/Inflammation
	Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) 是大黄的一种活性成分，通过抑制精氨酸酶活性激活内皮细胞一氧化氮合酶，抑制Arginase I 和Arginase II，IC50值分别为 11.22 和 11.06 μM。它可增加肺血氧分压，减少肺间质水肿，从而保护肺损伤。
T4788	L-Norvaline	Others; Endogenous Metabolite	Metabolism; Others
	L-Norvaline 是一种精氨酸酶抑制剂，也是一种非蛋白支链氨基酸。 L-Norvaline 先前已被报道为枯草芽孢杆菌抗真菌肽的天然成分。 L-Norvaline 和其他修饰的支链氨基酸在研究中受到了关注，因为它们似乎被掺入到大肠杆菌中发现的一些重组蛋白中。
T38241	2-Aminoimidazole
	2-Aminoimidazole is a potent antibiofilm agent and adjuvant to antimicrobial treatments, which effectively disrupts bacterial self-protection mechanisms by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. Additionally, 2-Aminoimidazole acts as a weak noncompetitive inhibitor of human arginase I, with a Ki value of 3.6 mM[1][2][3].
TN6456	N-trans-caffeoyloctopamine
	N-trans-Caffeoyltyramine has both arginase inhibitory property and antioxidant capacity.
T11802	L-Canaline	Others	Others
	L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. Additionally, L-Canaline acts as a cytotoxic metabolite produced from L-canavanine through arginase catalysis and serves as a potent and irreversible inhibitor of ornithine aminotransferase.

天然产物

Cat.No: T11054

Synonym: 2-Aminopentanoic acid,DL-正缬氨酸

Target: Arginase, Endogenous Metabolite

Piceatannol 3'-O-glucoside

Cat.No: T3S0401

Synonym: 白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷

Target: Arginase, NO Synthase

Cat.No: T4788

Target: Others, Endogenous Metabolite

2-Aminoimidazole

Cat.No: T38241

N-trans-caffeoyloctopamine

Cat.No: TN6456

Cat.No: T11802

Target: Others

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