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9

抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T1406 Amantadine hydrochloride

盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride

Dopamine Receptor; Influenza Virus GPCR/G Protein; Microbiology/Virology; Neuroscience
Amantadine hydrochloride (CI-719) 是一种抗病毒药物,用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道,从而阻止病毒 RNA 释放到感染细胞的细胞质中。
T1406L Amantadine sulfate

1-Adamantanamine Sulfate

Amantadine is used both as an antiviral and an anti-parkinsonian drug. Amantadine is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. The drug has many effects in the brain, including the rel
T0645 N-(1-Adamantyl)acetamide

Others Others
N-(1-Adamantyl)acetamide 用作合成amantadine hydrochloride 的中间体。
T1443 Memantine hydrochloride

3,5-二甲基金刚胺盐酸盐,盐酸美金刚,Namenda,Memantine HCl,D-145 (hydrochloride)

P450; GluR; NMDAR; Autophagy; iGluR Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
Memantine hydrochloride (Memantine HCl) 是一种具有一些多巴胺能作用的金刚烷胺衍生物,是一种温和的 NMDA 受体非竞争性拮抗剂,能够抑制 CYP2B6 和 CYP2D6。它可作为抗帕金森剂。
T20993 Memantine

Others Others
Memantine 是口服具有活性的、非竞争性的N-甲基-D-天冬氨酸受体拮抗剂,可用于研究中重度阿尔茨海默病。
T13209 Tromantadine

HSV Microbiology/Virology
Tromantadine is an amantadine derivative with antiherpetic activity (inhibits HSV-1 and HSV-2 replication).
T24428 M090

M 090,M-090

M090 is a potent inhibitor against amantadine-resistant viruses, including the 2009 H1N1 pandemic strains and oseltamivir-resistant viruses.
T13209L Tromantadine hydrochloride

HSV Microbiology/Virology
Tromantadine hydrochloride is an amantadine derivative with antiherpetic activity (inhibits HSV-1 and HSV-2 replication).
T38145 Eltoprazine

Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no...

化合物

Amantadine hydrochloride
Cat.No: T1406
Synonym: 盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride
Target: Dopamine Receptor, Influenza Virus
Amantadine sulfate
Cat.No: T1406L
Synonym: 1-Adamantanamine Sulfate
Target:
N-(1-Adamantyl)acetamide
Cat.No: T0645
Synonym:
Target: Others
Memantine hydrochloride
Cat.No: T1443
Synonym: 3,5-二甲基金刚胺盐酸盐,盐酸美金刚,Namenda,Memantine HCl,D-145 (hydrochloride)
Target: P450, GluR, NMDAR, Autophagy, iGluR
Memantine
Cat.No: T20993
Synonym:
Target: Others
Tromantadine
Cat.No: T13209
Synonym:
Target: HSV
M090
Cat.No: T24428
Synonym: M 090,M-090
Target:
Tromantadine hydrochloride
Cat.No: T13209L
Synonym:
Target: HSV
Eltoprazine
Cat.No: T38145
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T7060 Amantadine

1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine

Others Others
Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。

天然产物

Amantadine
Cat.No: T7060
Synonym: 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine
Target: Others
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