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Cat. No. | Product Name | Target | Signaling Pathways |
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T6396 |
(R)-(-)-Gossypol acetic acid
(-)-Gossypol acetic acid,AT-101 (acetic acid),(R)-Gossypol acetic acid,AT101醋酸,AT101,AT101 acetate |
BCL; Autophagy | Apoptosis; Autophagy |
(R)-(-)-Gossypol acetic acid (AT101 acetate) 是天然产物 Gossypol 的左旋异构体,与 Bcl-2、Bcl-xL 和 Mcl-1 结合,Ki 为 0.32 μM、0.48 μM 和 0.18 μM。 | |||
T26686 |
AV-101
L-4-Cl-KYN,L-4-chlorokynurenine,4-Cl-KYN,4ClKYN,4-Chlorokynurenine,(S)-4-Chlorokynurenine |
NMDAR | Neuroscience |
AV-101 (4-Cl-KYN) 是 NMDA 受体甘氨酸位点的前药拮抗剂,具有抗抑郁活性,可减少 MPTP 猴子中左旋多巴诱导的运动障碍。 | |||
T36935 |
PKUMDL-LC-101-D04
GPX4-Activator-1d4,PKUMDL-LC-101-D04 |
GPX | oxidation-reduction |
PKUMDL-LC-101-D04是一种高效的谷胱甘肽过氧化物酶4(GPX4)的异位激活剂,是一种铁死亡的调节剂。 当在无细胞试验中使用浓度为20 μM 时,GPX4活性增加到对照水平的150%;在野生型而非Gpx4-/-小鼠胚胎成纤维细胞(MEF)提取物中使用浓度为61 μM 时,GPX4活性增加到对照水平的150%。PKUMDL-LC-101-D04(200 μM)能减少胆固醇过氧化氢诱导的MEF 死亡。 | |||
T3631 |
PF-8380
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PDE | Metabolism |
PF8380 是有效的autotaxin 抑制剂,在体外酶实验和人类全血细胞实验中的IC50分别为 2.8 nM 和 101 nM。 | |||
T26048 |
RB 101
RB101,RB-101 |
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RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase. | |||
T71290 |
EVT-101 HCl
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EVT-101 is a GluN2B antagonist, binding at the same GluN1/GluN2B dimer interface as ifenprodil but adopting a remarkably different binding mode involving a distinct subcavity and receptor interactions. | |||
T70049 |
Ro 04-5595 free base
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Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol/L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific binding, defined with a new NR2B-specific antagonist Ro 04-5595 at 10 microM was fully inhibited by several compounds with the following rank order of affinities--Ro 25-6981 > CP-101,606 > Ro 04-5595 = ifenprodil >> eliprodil > haloperidol > spermine > spermidine > MgCl2 > CaCl2--and... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2730 |
Gossypol (acetic acid)
(±)-Gossypol-acetic acid,Pogosin,AT101,醋酸棉酚,乙酸棉子酚,Gossypol acetic acid |
BCL | Apoptosis |
Gossypol acetic acid (AT101) 是一种从棉籽中分离出来的多酚天然产物,分别与 Bcl-xL 蛋白和 Bcl-2蛋白结合,Ki 值分别为 0.5-0.6 μM 和 0.2-0.3 mM。 |